Patents by Inventor Nicole Le

Nicole Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MASKED ACTIVATABLE CYTOKINE CONSTRUCTS AND RELATED COMPOSITIONS AND METHOD
    Publication number: 20240124546
    Abstract: Provided herein are activatable cytokine constructs that include: (a) a first monomer construct comprising a first peptide mask (PM1), a third cleavable moiety (CM3), a first mature cytokine protein (CP1), a first cleavable moiety (CM1), and a first dimerization domain (DD1), wherein the CM1 is positioned between the CP1 and the DD1, and the CM3 is positioned between the PM1 and CP1; and (b) a second monomer construct comprising a second mature cytokine protein (CP2), a second cleavable moiety (CM2), and a second dimerization domain (DD2), where the CM2 is positioned between the CP2 and the DD2, where: the DD1 and the DD2 bind each other; and where the ACC is characterized by a reduction in at least one activity of the CP1 and/or CP2 as compared to a control level of the at least one activity of the CP1 and/or CP2.
    Type: Application
    Filed: May 25, 2023
    Publication date: April 18, 2024
    Applicant: CytomX Therapeutics, Inc.
    Inventors: Sayantan MITRA, Nicole G. LAPUYADE, Hikmat Haizar ASSI, Madan M. PAIDHUNGAT, Dylan L. DANIEL, Erwan LE SCOLAN, Walter A. BOGDANOFF, Na CAI, Hsin WANG, Alexey Yevgenyevich BEREZHNOY
  • Methods for harvesting mammalian cell cultures
    Patent number: 11384378
    Abstract: The invention provides methods and materials for culturing mammalian cells and harvesting recombinant protein.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: July 12, 2022
    Assignee: AMGEN INC.
    Inventors: Chetan Goudar, Sean Cole, Nicole Le, Henry Lin, Jonathan Lull, Tharmala Tharmalingam
  • METHODS FOR HARVESTING MAMMALIAN CELL CULTURES
    Publication number: 20170114381
    Abstract: The invention provides methods and materials for culturing mammalian cells and harvesting recombinant protein.
    Type: Application
    Filed: June 4, 2015
    Publication date: April 27, 2017
    Applicant: AMGEN INC.
    Inventors: Chetan GOUDAR, Sean COLE, Nicole LE, Henry LIN, Jonathan LULL, Tharmala THARMALINGAM
  • Methods for modulating mannose content of recombinant proteins
    Patent number: 9359435
    Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: June 7, 2016
    Assignee: Amgen Inc.
    Inventors: Jian Wu, Nicole Le, Michael De La Cruz, Gregory Flynn
  • METHODS FOR MODULATING MANNOSE CONTENT OF RECOMBINANT PROTEINS
    Publication number: 20130330770
    Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.
    Type: Application
    Filed: January 14, 2013
    Publication date: December 12, 2013
    Inventors: Jian WU, Nicole LE, Michael DE LA CRUZ, Gregory FLYNN
  • Methods for modulating mannose content of recombinant proteins
    Patent number: 8354105
    Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: January 15, 2013
    Assignee: Amgen Inc.
    Inventors: Jian Wu, Nicole Le, Michael De La Cruz, Gregory Flynn
  • Methods for modulating mannose content of recombinant proteins
    Publication number: 20110097336
    Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 28, 2011
    Applicant: AMGEN INC.
    Inventors: Jian WU, Nicole LE, Michael DE LA CRUZ, Gregory FLYNN
  • Methods for modulating mannose content of recombinant proteins
    Publication number: 20070190057
    Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.
    Type: Application
    Filed: December 22, 2006
    Publication date: August 16, 2007
    Inventors: Jian Wu, Nicole Le, Michael De La Cruz, Gregory Flynn
  • Spray device containing nitrogen-carbon dioxide propellent gas mixture
    Patent number: 6415992
    Abstract: The invention concerns a new personal spray device pressurized by a gas mixture comprising nitrogen and carbon dioxide for the fine spray dispersion of, for example, liquids or atomizable compositions. The spray device prevents the formation of liquid jet or ion precipitates. Preferably, the spray device contains mineralized waters and controls the pH and the microbial content of the mineralized waters.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: July 9, 2002
    Assignee: L'Oreal
    Inventors: Gilles Blondeel, Nicole Le Calvez