Abstract: Provided herein are methods and compositions for treating congenital hemophilia with platelets and/or platelet derivatives. In some cases, the platelets and or platelet derivatives are loaded with an anti-fibrinolytic.

Abstract: A computer-implemented technique is described herein that receives captured stroke information when a user enters a handwritten note using an input capture device. The technique then analyzes the captured stroke information to produce output analysis information. Based on the output analysis information, the technique modifies the captured stroke information into an actionable form that contains one or more actionable content items, while otherwise preserving the original form of the captured stroke information. The technique then presents the modified stroke information on a canvas display device. The user may subsequently activate one or more actionable content items in the modified stroke information to perform various supplemental tasks that pertain to the handwritten note. In one case, for example, the technique can recognize the presence of entity items and/or list items in the note and then reproduce them in an actionable form.

Abstract: Concentrated surfactant compositions that include an alkyl alkoxylated sulfate surfactant and an alkoxylated polyalkyleneimine, and process for making such compositions. Detergent compositions made from such concentrated surfactant compositions, and process for making such detergent compositions.

Abstract: Provided herein are mRNA agent-loaded platelets, methods of preparing mRNA agent-loaded platelets, and methods of using mRNA agent-loaded platelets. In some embodiments, methods of loading mRNA agents into platelets include contacting platelets with an mRNA agent, a transfection reagent, and a loading buffer that can include a salt, a base, a loading agent, and optionally at least one organic solvent.

Abstract: Provided herein in some embodiments is a method of treating a disease or condition such as an antibiotic resistant bacterial infection, a gram negative bacterial infection, a gram positive bacterial infection, a fungal infection, protozoa, a hemorrhagic virus, such as Ebola or Dengue, or a non-hemorrhagic virus, such as a coronavirus, in a subject, comprising administering to the subject in need thereof an effective amount of a composition comprising platelets or platelet derivatives, such as freeze-dried platelets; and an incubating agent comprising one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent.

Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent.

Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.

Abstract: Antimicrobial polymer composite materials are disclosed that are suitable for making oral devices used in dental applications, such as denture bases. Acrylic resin composite materials comprising antimicrobial polymers and antimicrobial fillers provide reduction in common oral microorganisms after long-term aging, with reduced release rate of antimicrobial agents from the composite material. Antimicrobial polymers are prepared from compositions comprising acrylate and/or methacrylate monomers and polymerizable quaternary ammonium silicon-containing compounds.

Abstract: A wearable posture monitoring device is provided. The device includes a first posture sensor to measure a first bend parameter associated with shoulders of a user and a second posture sensor to measure a second bend parameter associated with vertebral column of the user. The device includes a control unit operatively coupled to the first posture sensor and the second posture sensor and is configured to compare the first bend parameter with a first predefined reference value and the second bend parameter with a second predefined reference value to detect an improper bend in one or more of the shoulders and vertebral column of the user. The control unit is further configured to display a visual indication, on a display interface associated with the posture monitoring device, to indicate the detected improper bend of one or more of the shoulders and vertebral column of the user.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: The present invention relates generally to methods of making surfactant compositions and detergent compositions.

Abstract: In some embodiments provided herein is a method of preparing cargo-loaded platelets, comprising: treating platelets with a cargo and with a loading buffer comprising a salt, a base, a loading agent, and optionally ethanol, to form the cargo-loaded platelets.

Abstract: Provided herein are RNA agent-loaded platelets, methods of preparing RNA agent-loaded platelets, and methods of using RNA agent-loaded platelets. In some embodiments, methods of loading RNA agents into platelets include treating platelets with a RNA agent, a cationic transfection reagent, and a loading buffer that can include a salt, a base, a loading agent, and optionally at least one organic solvent.

Abstract: Provided herein are mRNA agent-loaded platelets, methods of preparing mRNA agent-loaded platelets, and methods of using mRNA agent-loaded platelets. In some embodiments, methods of loading mRNA agents into platelets include treating platelets with an mRNA agent, a transfection reagent, and a loading buffer that can include a salt, a base, a loading agent, and optionally at least one organic solvent.

Abstract: Disclosed herein are compositions and fluidic devices that include a filler fluid having a siloxane block co-polymer solubilized in the filler fluid. Also disclosed herein are related kits and methods for using the fluidic devices for various uses, such as the polymerase chain reaction or preparations for sequencing reactions.

Abstract: Systems and methods for facilitating handwritten personalized messages using a digital personal assistant are provided. A message for a user associated with the digital personal assistant is initiated. The message is to be communicated to a recipient by way of the digital personal assistant. Content is generated for the message, and the user may add handwritten content to the message. Once the recipient of the message is determined and the message is completed, the message is communicated to the recipient.

Abstract: A method and a system for providing information about a posting from multiple sources are provided. For example, the method may comprise storing a posting that was submitted by a first user in an online publication system. Then, one or more stored inquiries associated with the posting may be retrieved. Finally, a response is selectively retrieved from a response source. The retrieved response may correspond to the stored inquiry and the posting. The response source is at least one of the posting, the online publication system, the first user, and a user account of a second user.

Abstract: A computer-implemented technique is described herein that receives captured stroke information when a user enters a handwritten note using an input capture device. The technique then analyzes the captured stroke information to produce output analysis information. Based on the output analysis information, the technique modifies the captured stroke information into an actionable form that contains one or more actionable content items, while otherwise preserving the original form of the captured stroke information. The technique then presents the modified stroke information on a canvas display device. The user may subsequently activate one or more actionable content items in the modified stroke information to perform various supplemental tasks that pertain to the handwritten note. In one case, for example, the technique can recognize the presence of entity items and/or list items in the note and then reproduce them in an actionable form.

Abstract: A computer-implemented technique is described herein that receives captured stroke information when a user enters a handwritten note using an input capture device. The technique then analyzes the captured stroke information to produce output analysis information. Based on the output analysis information, the technique modifies the captured stroke information into an actionable form that contains one or more actionable content items, while otherwise preserving the original form of the captured stroke information. The technique then presents the modified stroke information on a canvas display device. The user may subsequently activate one or more actionable content items in the modified stroke information to perform various supplemental tasks that pertain to the handwritten note. In one case, for example, the technique can recognize the presence of entity items and/or list items in the note and then reproduce them in an actionable form.