Patents by Inventor Nicole Parrish

Nicole Parrish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of bacterial growth
    Patent number: 10695322
    Abstract: New antimicrobials targeting L,D-transpeptidases, non-classical cysteine peptidases, have been developed and their unique chemical structures identified. Carbapenems and penems of the present invention are unique among ?-lactams as they acylate and inhibit L,D-transpeptidases, which likely results in their superior antimicrobial potency. These new antimicrobial agents can be used alone, or in combination with other classic antimicrobial agents that target D,D transpeptidases, when treating bacterial infections.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: June 30, 2020
    Assignees: The Johns Hopkins University, Rutgers, The State University of New Jersey
    Inventors: Gyanu Lamichhane, Craig A. Townsend, Evan Lloyd, Amit Kaushik, Pankaj Kumar, Joel Freundlich, Shaogang Li, Sean Ekins, Nicole Parrish
  • NOVEL INHIBITORS OF BACTERIAL GROWTH
    Publication number: 20190167637
    Abstract: New antimicrobials targeting L,D-transpeptidases, non-classical cysteine peptidases, have been developed and their unique chemical structures identified. Carbapenems and penems of the present invention are unique among ?-lactams as they acylate and inhibit L,D-transpeptidases, which likely results in their superior antimicrobial potency. These new antimicrobial agents can be used alone, or in combination with other classic antimicrobial agents that target D,D transpeptidases, when treating bacterial infections.
    Type: Application
    Filed: January 26, 2017
    Publication date: June 6, 2019
    Inventors: Gyanu Lamichhane, Craig A. Townsend, Evan Lloyd, Amit Kaushik, Pankaj Kumar, Joel Freundlich, Shaogang Li, Sean Ekins, Nicole Parrish
  • ANTI-MYCOBACTERIAL FORMULATION
    Publication number: 20070244199
    Abstract: The invention provides anti-microbial compositions, including compositions with inhibitory activity against mycobacteria. The invention further provides methods for treating microbial infections, including the treatment of mycobacterial infection and diseases such as tuberculosis.
    Type: Application
    Filed: February 8, 2007
    Publication date: October 18, 2007
    Applicant: FASgen Inc.
    Inventors: Nicole Parrish, Albert Owens, James Dick
  • Methods of treating microbial infections in humans and animals
    Publication number: 20060135568
    Abstract: A method of treating a subject with a microbially-based infection, comprising the administration of a compound to the subject. The compound is able to decrease ATP levels in the microbe by at least 10% compared to controls after 24 hours in an in vitro test, without killing mammalian cells during the same time period. The decrease in ATP levels is measured by: (1) removing the cells from the testing location and putting them on ice; (2) harvesting the cells at 4 degrees C. by centrifugation and disrupting it with bead-beating in an ATP extraction buffer; (3) removing cellular debris by centrifugation at 4 degrees C., leaving an ATP-containing supernatant; (4) measuring the amount of ATP present in the supernatant by a bioluminescence assay at 4 degrees C.
    Type: Application
    Filed: July 9, 2003
    Publication date: June 22, 2006
    Inventors: Craig Townsend, James Dick, Nicole Parrish, Minerva Hughes