Patents by Inventor Nicole Pirkl

Nicole Pirkl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • UNIVERSAL CALIBRATION FOR QUANTITATIVE MASS SPECTROMETRY
    Publication number: 20240110932
    Abstract: The present invention relates to a method of determining an analyte in a sample by mass spectrometry (MS), the method comprising (a) admixing a pre-determined amount of internal calibrator to said sample, wherein said internal calibrator comprises at least two non-identical isotopologues of the analyte at predetermined amounts; (b) determining MS signals of ions generated from said analyte (analyte signal) and from said at least two isotopologues (isotopologue signals); (c) providing a calibration based on the analyte signal and the isotopologue signals determined in step (b); and (d) determining said analyte based on the calibration provided in step (c). Further, the present invention relates to devices, systems, and uses related thereto.
    Type: Application
    Filed: December 15, 2023
    Publication date: April 4, 2024
    Inventors: Johannes Pflieger, Nicole Pirkl, Martin Rempt, Christoph Zuth
  • REAGENT FOR MASS SPECTROMETRY
    Publication number: 20240092742
    Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
    Type: Application
    Filed: November 2, 2023
    Publication date: March 21, 2024
    Inventors: Dieter Heindl, Hans-Peter Josel, Uwe Kobold, Christoph Seidel, Martin Rempt, Andreas Leinenbach, Giuseppe Prencipe, Silvia Baecher, Simon Ferdinand Loibl, Anna-Skrollan Geiermann, Jelena Milic, Nicole Pirkl
  • Reagent for mass spectrometry
    Patent number: 11885818
    Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: January 30, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Dieter Heindl, Hans-Peter Josel, Uwe Kobold, Christoph Seidel, Martin Rempt, Andreas Leinenbach, Giuseppe Prencipe, Silvia Baecher, Simon Ferdinand Loibl, Anna-Skrollan Geiermann, Jelena Milic, Nicole Pirkl
  • Reagent for mass spectrometry
    Patent number: 11845733
    Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: December 19, 2023
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Dieter Heindl, Hans-Peter Josel, Uwe Kobold, Christoph Seidel, Martin Rempt, Andreas Leinenbach, Giuseppe Prencipe, Silvia Baecher, Simon Ferdinand Loibl, Anna-Skrollan Geiermann, Jelena Milic, Nicole Pirkl
  • DETECTION OF AN ANALYTE OF INTEREST BY CROSS SPRAY ESI MASS SPECTROMETRY
    Publication number: 20230314444
    Abstract: The present invention relates to a method, a diagnostic system, a dopand and the use thereof for the enhancement of detection of an analyte of interest by Cross Spray ESI mass spectrometry.
    Type: Application
    Filed: June 2, 2023
    Publication date: October 5, 2023
    Inventors: Samir Karaca, Nicole Pirkl, Martin Rempt
  • REAGENT FOR MASS SPECTROMETRY
    Publication number: 20210198217
    Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
    Type: Application
    Filed: January 21, 2021
    Publication date: July 1, 2021
    Inventors: Dieter Heindl, Hans-Peter Josel, Uwe Kobold, Christoph Seidel, Martin Rempt, Andreas Leinenbach, Giuseppe Prencipe, Silvia Baecher, Simon Ferdinand Loibl, Anna-Skrollan Geiermann, Jelena Milic, Nicole Pirkl
  • REAGENT FOR MASS SPECTROMETRY
    Publication number: 20210188788
    Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
    Type: Application
    Filed: January 21, 2021
    Publication date: June 24, 2021
    Inventors: Dieter Heindl, Hans-Peter Josel, Uwe Kobold, Christoph Seidel, Martin Rempt, Andreas Leinenbach, Giuseppe Prencipe, Silvia Baecher, Simon Ferdinand Loibl, Anna-Skrollan Geiermann, Jelena Milic, Robert Hahn, Nicole Pirkl
  • REAGENT FOR MASS SPECTROMETRY
    Publication number: 20210140983
    Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
    Type: Application
    Filed: January 21, 2021
    Publication date: May 13, 2021
    Inventors: Dieter Heindl, Hans-Peter Josel, Uwe Kobold, Christoph Seidel, Martin Rempt, Andreas Leinenbach, Giuseppe Prencipe, Silvia Baecher, Simon Ferdinand Loibl, Anna-Skrollan Geiermann, Jelena Milic, Nicole Pirkl