Patents by Inventor Nicole POULI

Nicole POULI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridopyrazine compounds and uses thereof
    Patent number: 11117894
    Abstract: Disclosed herein, inter alia, are pyridopyrazines and methods of using the same.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: September 14, 2021
    Assignees: City of Hope, National and Kapodistrian University of Athens
    Inventors: Sangkil Nam, David Horne, Ravi Salgia, Alexios-Leandros Skaltsounis, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos
  • Compounds, linked with haptens, for the detection of senescent cells
    Patent number: 11034839
    Abstract: The present disclosure relates to compounds of the formula (1) that function as senescent cell detectors: wherein the SBB analogues refer to de novo synthesized derivatives with structural similarity to the Sudan Black B dye, L is an appropriate chemical bond and hapten is biotin, or digoxigenin, or 2,4-dinitrophenol, or fluorescein, but more preferably biotin. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: June 15, 2021
    Assignee: THE UNIVERSITY OF MANCHESTER
    Inventors: Vassilis Gorgoulis, Paul Townsend, Panayiotis Marakos, Nikolaos Lougiakis, Nicole Pouli, Nikolaos Kastrinakis
  • PYRIDOPYRAZINE COMPOUNDS AND USES THEREOF
    Publication number: 20210139476
    Abstract: Disclosed herein, inter alia, are pyridopyrazines and methods of using the same.
    Type: Application
    Filed: June 21, 2018
    Publication date: May 13, 2021
    Inventors: Sangkil Nam, David Horne, Ravi Salgia, Alexios-Leandros Skaltsounis, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos
  • Compounds for the detection of senescent cells
    Patent number: 10947390
    Abstract: The present disclosure relates to de novo synthesized, chemical compounds of the formula (1) or (2) that function as senescent cell detectors wherein R1, R2, R3, R4 and Z are as defined herein. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds. The compounds have the ability to react with lipofuscin, in an analogous manner to the histochemical dye Sudan Black B (SBB).
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: March 16, 2021
    Assignee: THE UNIVERSITY OF MANCHESTER
    Inventors: Vassilis Gorgoulis, Paul Townsend, Panayiotis Marakos, Nikolaos Lougiakis, Nicole Pouli, Nikolaos Kastrinakis
  • COMPOUNDS FOR THE DETECTION OF SENESCENT CELLS
    Publication number: 20190315966
    Abstract: The present disclosure relates to de novo synthesized, chemical compounds of the formula (1) or (2) that function as senescent cell detectors wherein R1, R2, R3, R4 and Z are as defined herein. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds. The compounds have the ability to react with lipofuscin, in an analogous manner to the histochemical dye Sudan Black B (SBB).
    Type: Application
    Filed: June 28, 2017
    Publication date: October 17, 2019
    Inventors: Vassilis GORGOULIS, Paul TOWNSEND, Panayiotis MARAKOS, Nikolaos LOUGIAKIS, Nicole POULI, Nikolaos KASTRINAKIS
  • COMPOUNDS, LINKED WITH HAPTENS, FOR THE DETECTION OF SENESCENT CELLS
    Publication number: 20190225812
    Abstract: The present disclosure relates to compounds of the formula (1) that function as senescent cell detectors: wherein the SBB analogues refer to de novo synthesized derivatives with structural similarity to the Sudan Black B dye, L is an appropriate chemical bond and hapten is biotin, or digoxigenin, or 2,4-dinitrophenol, or fluorescein, but more preferably biotin. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds.
    Type: Application
    Filed: June 28, 2017
    Publication date: July 25, 2019
    Inventors: Vassilis GORGOULIS, Paul TOWNSEND, Panayiotis MARAKOS, Nikolaos LOUGIAKIS, Nicole POULI, Nikolaos KASTRINAKIS