Abstract: Delivery of antioxidants (Vitamin C, Vitamin E, riboflavin, and beta-carotene) directly to the large intestine were seen to decrease the population of Fusobacterium in the gut microbiome. An increased population of these bacteria is associated with Fusobacterium bacteremia as a co-morbidity with any one of: malignancy, dementia, chronic obstructive lung disease, diabetes, heart disease, alcoholism, disease(s) requiring dialysis, and stroke; colorectal cancer; digestive diseases including Ulcerative colitis; Crohn's disease; and/or Pediatric or adult inflammatory bowel disease; colorectal and other cancers, inflammatory bowel disease, adverse pregnancy-related conditions, and HIV.

Abstract: Certain embodiments involve a system comprising at least one processor; and a memory storing instructions which when executed by the at least one processor cause the at least one processor to: cause a first symbol array to be selected and displayed on at least one display in a display area, the first symbol array including a plurality of selected symbols from each reel of a plurality of reels at respective symbol locations of the display area; add at least one first Wild symbol to the display; cause a second symbol array to be selected and displayed on the at least one display in the display area, the second symbol array including a plurality of selected symbols from each reel at the respective symbol locations of the display area; add at least one second Wild symbol to the display; and move the at least one first Wild symbol relative to the display area.

Abstract: A described gaming system implements an arrangement wherein, as part of a first base game instance, a gaming device is caused to include, at a first symbol position of a symbol array to be implemented by a gaming device, a first Wild symbol at a first symbol position on a reel of a plurality of reels; and, as part of a second base game instance following the first game instance, a modification of the reel of the plurality of reels is performed to move the first Wild symbol into a second symbol position different than the first symbol position.

Abstract: The population of Dialister spp. bacteria in the gut microbiome is lower in people with various diseases. We have found that administration of vitamins/vitamin combinations such as: beta-carotene, Vitamin A, Vitamin D, Vitamin B5, Vitamin B2, a combination of Vitamin B2 and Vitamin C, Vitamin K, DHA, or EPA, when administered directly to the large intestine, so that it provides nourishment to the gut microbiome directly, can result in an increase of Dialister spp.

Abstract: The population of Coprococcus spp. bacteria in the gut microbiome is lower in people with various diseases. We have found that administration of vitamins / vitamin combinations such as : the combination of Vitamin B2 and C; Vitamin D3; beta-carotene, and Vitamin B5, when administered directly to the gut, so that it provides nourishment to the gut microbiome directly, can result in an increase of Coprococcus spp.

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat dysfunctions in a gastrointestinal barrier. The present disclosure further relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat infections.

Abstract: Methods and compositions for treating modulating and/or ameliorating non-light-induced, particularly non-UV-induced, skin aging in a human, for reducing the basal MMP-10 expression in unirradiated cells of an organism and/or reducing the basal MMP-1 RNA transcription and protein translation in unirradiated cells of an organism, and/or for modulating the effects of UVA-induced RNA transcription and polypeptide translation of a matrix metalloprotease, which include administering an effective amount of ?-carotene, a precursor of ?-carotene, a salt of ?-carotene, or a combination of two or more thereof to an organism, particularly a mammal, more particularly a human, in need thereof.

Abstract: Methods and compositions for treating modulating and/or ameliorating non-light-induced, particularly non-UV-induced, skin aging in a human, for reducing the basal MMP-10 expression in unirradiated cells of an organism and/or reducing the basal MMP-1 RNA transcription and protein translation in unirradiated cells of an organism, and/or for modulating the effects of UVA-induced RNA transcription and polypeptide translation of a matrix metalloprotease, which include administering an effective amount of ?-carotene, a precursor of ?-carotene, a salt of ?-carotene, or a combination of two or more thereof to an organism, particularly a mammal, more particularly a human, in need thereof.

Abstract: Methods and compositions for treating modulating and/or ameliorating non-light-induced, particularly non-UV-induced, skin aging in a human, for reducing the basal MMP-10 expression in unirradiated cells of an organism and/or reducing the basal MMP-1 RNA transcription and protein translation in unirradiated cells of an organism, and/or for_modulating the effects of UVA-induced RNA transcription and polypeptide translation of a matrix metalloprotease, which include administering an effective amount of ?-carotene, a precursor of ?-carotene, a salt of ?-carotene, or a combination of two or more thereof to an organism, particularly a mammal, more particularly a human, in need to thereof.

Abstract: Methods and compositions—particularly compositions containing ?-carotene—for modulating the expression of genes that effect or influence cellular health or protect against cellular damage, e.g., skin aging, are provided. More particularly, a method is provided for screening for a compound that modulates an effect of UV irradiation on eukaryotic cells. Methods and compositions for ameliorating the effects of non-UV radiation induced skin aging and for modulating UVA-induced gene expression on skin aging are also provided. Further provided are methods and compositions for enhancing UVA-induced tanning of the skin, for promoting cell differentiation in UVA-irradiated cells of an organism, and for modulating stress-induced induction of a gene in an organism.