Patents by Inventor Nicole ULMER
Nicole ULMER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10948483Abstract: Provided is a method for control and/or monitoring and/or optimization of a chromatographic process, in which the method comprises at least 2 columns which are operated, alternatingly, wherein this operation can be carried out in that the at least 2 columns are operated in interconnected and disconnected states, wherein the columns switch positions after such a sequence of interconnected and disconnected state, and wherein downstream of at least one, or of each column, a detector is located capable of detecting the desired product and/or impurities when passing the detector.Type: GrantFiled: May 11, 2017Date of Patent: March 16, 2021Assignee: ChromaCon AGInventors: Thomas Muller-Spath, Lars Aumann, Guido Strohlein, Michael Bavand, Nicole Ulmer
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Publication number: 20190070523Abstract: A chromatographic purification method for the isolation of a desired product fraction from a mixture using 2 chromatographic columns, comprises, within one cycle to be carried out at least once, the following steps: a first batch step, wherein said columns are disconnected and a first column is loaded with feed and its outlet is directed to waste, and from a second column desired product is recovered and subsequently the second column is regenerated; a first interconnected step, wherein the outlet of the first column is connected to the inlet of the second column, the first column is loaded beyond its dynamic breakthrough capacity with feed, and the outlet of the second column is directed to waste, a second batch step analogous to the first batch step but with exchanged columns; and a second interconnected step, analogous to the first interconnected step but with exchanged columns.Type: ApplicationFiled: September 4, 2018Publication date: March 7, 2019Applicant: ChromaCon AGInventors: Thomas MULLER-SPATH, Lars AUMANN, Guido STROHLEIN, Michael BAVAND, Nicole ULMER
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Patent number: 10099156Abstract: A chromatographic purification method for the isolation of a desired product fraction from a mixture using 2 chromatographic columns, comprises, within one cycle to be carried out at least once, the following steps: a first batch step, wherein said columns are disconnected and a first column is loaded with feed and its outlet is directed to waste, and from a second column desired product is recovered and subsequently the second column is regenerated; a first interconnected step, wherein the outlet of the first column is connected to the inlet of the second column, the first column is loaded beyond its dynamic breakthrough capacity with feed, and the outlet of the second column is directed to waste, a second batch step analogous to the first batch step but with exchanged columns; and a second interconnected step, analogous to the first interconnected step but with exchanged columns.Type: GrantFiled: January 31, 2014Date of Patent: October 16, 2018Assignee: ChromaCon AGInventors: Thomas Müller-Späth, Lars Aumann, Guido Strohlein, Michael Bavand, Nicole Ulmer
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Publication number: 20170241992Abstract: Provided is a method for control and/or monitoring and/or optimization of a chromatographic process, in which the method comprises at least 2 columns which are operated, alternatingly, wherein this operation can be carried out in that the at least 2 columns are operated in interconnected and disconnected states, wherein the columns switch positions after such a sequence of interconnected and disconnected state, and wherein downstream of at least one, or of each column, a detector is located capable of detecting the desired product and/or impurities when passing the detector.Type: ApplicationFiled: May 11, 2017Publication date: August 24, 2017Applicant: ChromaCon AGInventors: Thomas MULLER-SPATH, Lars AUMANN, Guido STROHLEIN, Michael BAVAND, Nicole ULMER
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Patent number: 9073970Abstract: A chromatographic process for the enrichment of at least one compound of interest from a mixture is proposed, using chromatographic columns, wherein said process involves a sequence of the following steps: (i) a cyclic accumulation phase, in which the chromatographic columns are alternatingly operated in an interconnected phase, followed by a disconnected phase, wherein subsequently columns exchange places and wherein the phases are carried out sequentially; (ii) a cyclic separation phase, in which the chromatographic columns are alternatingly operated in an interconnected phase, followed by a disconnected phase, wherein after these phases columns exchange places to undergo the next interconnected and disconnected phases; and (iii) an elution phase, in which from the column, which at the end of phase (i) or at the end of phase (ii) contains the compound of interest, is extracted via the outlet.Type: GrantFiled: January 29, 2014Date of Patent: July 7, 2015Assignee: ChromaCon AGInventors: Thomas Müller-Späth, Guido Ströhlein, Lars Aumann, Michael Bavand, Nicole Ulmer
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Publication number: 20140299547Abstract: A chromatographic purification method for the isolation of a desired product fraction from a mixture using 2 chromatographic columns, comprises, within one cycle to be carried out at least once, the following steps: a first batch step, wherein said columns are disconnected and a first column is loaded with feed and its outlet is directed to waste, and from a second column desired product is recovered and subsequently the second column is regenerated; a first interconnected step, wherein the outlet of the first column is connected to the inlet of the second column, the first column is loaded beyond its dynamic breakthrough capacity with feed, and the outlet of the second column is directed to waste, a second batch step analogous to the first batch step but with exchanged columns; and a second interconnected step, analogous to the first interconnected step but with exchanged columns.Type: ApplicationFiled: January 31, 2014Publication date: October 9, 2014Applicant: ChromaCon AGInventors: Thomas MULLER-SPATH, Lars AUMANN, Guido STROHLEIN, Michael BAVAND, Nicole ULMER
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Publication number: 20140248643Abstract: A chromatographic process for the enrichment of at least one compound of interest from a mixture is proposed, using chromatographic columns, wherein said process involves a sequence of the following steps: (i) a cyclic accumulation phase, in which the chromatographic columns are alternatingly operated in an interconnected phase, followed by a disconnected phase, wherein subsequently columns exchange places and wherein the phases are carried out sequentially; (ii) a cyclic separation phase, in which the chromatographic columns are alternatingly operated in an interconnected phase, followed by a disconnected phase, wherein after these phases columns exchange places to undergo the next interconnected and disconnected phases; and (iii) an elution phase, in which from the column, which at the end of phase (i) or at the end of phase (ii) contains the compound of interest, is extracted via the outlet.Type: ApplicationFiled: January 29, 2014Publication date: September 4, 2014Applicant: CHROMACON AGInventors: Thomas MÜLLER-SPÄTH, Guido STRÖHLEIN, Lars AUMANN, Michael BAVAND, Nicole ULMER