Abstract: Methods relating to treatment and diagnosis of head injury are provided herein.

Abstract: A method can apply permutation procedures to mediation and moderation tests of multiple hypotheses, while controlling the rate of false positives. The techniques presented here through a platform-independent tool can be applied to a variety of datasets in diverse and interdisciplinary fields, such as biology and medicine, where integration of multi-scale data is utilized to unmask disease diagnosis, prognosis, susceptibility/resilience, treatment optimization, and biopharmaceutical development for any brain-based, psychological, or medical illness. This platform allows for study of human illness where animal models are proving inadequate.