Patents by Inventor Nicole Welsch
Nicole Welsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220315698Abstract: A method for producing polyether carbonate polyols via the following steps: (i) accumulating alkylene oxide and carbon dioxide on a H-functional starter substance in the presence of a double metal cyanide catalyst or a metal complex catalyst based on the metals zinc and/or cobalt, wherein a reaction mixture containing the polyether carbonate polyol is obtained; and (ii) adding at least one component K to the reaction mixture containing the polyether carbonate polyol, wherein a buffer system suitable for buffering a pH value in the region of pH 3.0 to 9.0 is used as component K, wherein the component K is free from compounds containing P—OH— groups.Type: ApplicationFiled: July 24, 2020Publication date: October 6, 2022Inventors: Joerg Hofman, Kai Laemmerhold, Persefoni Hilken, Nicole Welsch, Hartmut Nefzger
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Patent number: 11419948Abstract: Ultra-low crosslinked microgels made of an ultra-low crosslinked polymer are provided. The microgels, also referred to as Platelet-like Particles (PLPs), preferably have <0.5% crosslinking densities. One or more of the polymers are conjugated with a fibrin-binding element or moiety, preferably H6, in an amount effective to confer to the microgel selective binding to fibrin under physiological conditions. The PLPs can recapitulate multiple key functions of platelets including binding, stabilizing and enhancing fibrin clot formation, responsiveness to injury cues, and induction of clot contraction. In a preferred embodiment, the microgel or PLP has little or no binding to soluble fibrinogen under physiological conditions compared to its binding to fibrin. The microgels or PLPs are prepared using crosslinker-free synthesis conditions, and can promote or induce clotting and clot contraction.Type: GrantFiled: February 4, 2019Date of Patent: August 23, 2022Assignees: Georgia Tech Research Corporation, University of Virginia Patent Foundation, North Carolina State UniversityInventors: Thomas H. Barker, Ashley Carson Brown, Louis Andrew Lyon, Sarah E. Stabenfeldt, Nicole Welsch, John Nicosia
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Publication number: 20220227928Abstract: A method for preparing polyether carbonate polyols by means of the following steps: (i) adding alkylene oxide and carbon dioxide onto an H-functional starter substance in the presence of a double metal cyanide catalyst or a metal complex catalyst based on the metals zinc and/or cobalt to obtain a reaction mixture containing the polyether carbonate polyol, (ii) introducing at least one component K to the reaction mixture containing the polyether carbonate polyol, characterized in that the component K is at least one compound selected from the group consisting of monocarboxylic acids, polycarboxylic acids, hydroxycarboxylic acids and vinylogous carboxylic acids, wherein compounds containing a phosphorus-oxygen bond or compounds of phosphorus that can form one or more P—O bonds through reaction with OH-functional compounds, and acetic acid are excluded from component K.Type: ApplicationFiled: June 3, 2020Publication date: July 21, 2022Inventors: Kai Laemmerhold, Joerg Hofmann, Persefoni Hilken, Nicole Welsch, Hartmut Nefzger
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Publication number: 20220177638Abstract: The invention relates to flame-retardant polyurethane foam materials or polyurethane/polyisocyanurate foam materials (also referred to individually or collectively as “PUR/PIR foam materials” below) and to methods for producing PUR/PIR foam materials by reacting a reaction mixture containing A1 an isocyanate-reactive component, A2 a propellant, A3 a catalyst, A4 optionally an additive, and A5 a flame retardant with B an isocyanate component, wherein the production is carried out using an index of 80 to 600. The invention is characterized in that the flame retardant A5 contains (hydroxymethyl)phosphonate and optionally the dimer thereof as component A5.1.Type: ApplicationFiled: March 30, 2020Publication date: June 9, 2022Inventors: Rolf Albach, Stephan Schleiermacher, Horst-Josef Schaefer, Hans-Peter Huber, Andre Neumann, Nicole Welsch, Catherine Loevenich
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Patent number: 11345775Abstract: The present invention relates to a method for producing polyurethane foams by reacting an isocyanate component with an isocyanate-reactive component comprising at least one polyethercarbonate polyol, the reaction taking place in the presence of a component K selected from one or more compounds from the group consisting of K1 esters of mono- or polybasic carboxylic acids whose (first) dissociation has a pKa of 0.5 to 4.0, K2 mono-, di- and polysulfonates of mono- and polyfunctional alcohols, and K3 one or more compounds from the group consisting of K 3.1 esters of phosphoric acid, phosphonic acid, phosphorous acid, phosphinic acid, phosphonous acid and phosphinous acid, these esters each containing no P—OH group, K3.Type: GrantFiled: December 6, 2016Date of Patent: May 31, 2022Assignee: Covestro Deutschland AGInventors: Bert Klesczewski, Jörg Hofmann, Karsten Malsch, Nicole Welsch, Klaus Lorenz, Hartmut Nefzger, Kai Laemmerhold
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Patent number: 11279809Abstract: The invention relates to flame-proofed polyurethane hard foam material or polyurethane/polyisocyanurate hard foam material (designated below individually or jointly also as “PUR/PIR hard foam material”) comprising phosphinates (also hypophosphite), and to a method for producing PUR/PIR hard foam materials through the implementation of a reaction mixture containing A1 an isocyanate-reactive component, A2 propellant, A3 catalyst, A4 optionally additive, A5 flame-proofing agent, B an isocyanate component, characterised in that the flame-proofing agent A5 contains a phosphine according to the formula (I)M[(R)2PO2]n, where R=in each case stands for H, C1- to C4-(hydroxy-)alkyl group or benzyl group, M=an element of the main groups 1 to 3, wherein hydrogen is excepted, and n=the number of the main group of M, and the proportion of the phosphine according to the formula (I) is 0.1 to 15 wt %, based on the total mass of components A1 to A5.Type: GrantFiled: August 2, 2019Date of Patent: March 22, 2022Assignee: Covestro Intellectual Property GmbH & Co. KGInventors: Rolf Albach, Torsten Hagen, Torsten Heinemann, Nicole Welsch
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Publication number: 20210309823Abstract: The invention relates to flame-proofed polyurethane hard foam material or polyurethane/polyisocyanurate hard foam material (designated below individually or jointly also as “PUR/PIR hard foam material”) comprising phosphinates (also hypophosphite), and to a method for producing PUR/PIR hard foam materials through the implementation of a reaction mixture containing A1 an isocyanate-reactive component, A2 propellant, A3 catalyst, A4 optionally additive, A5 flame-proofing agent, B an isocyanate component, characterised in that the flame-proofing agent A5 contains a phosphine according to the formula (I)M[(R)2PO2]n, where R=in each case stands for H, C1- to C4-(hydroxy-)alkyl group or benzyl group, M=an element of the main groups 1 to 3, wherein hydrogen is excepted, and n=the number of the main group of M, and the proportion of the phosphine according to the formula (I) is 0.1 to 15 wt %, based on the total mass of components A1 to A5.Type: ApplicationFiled: August 2, 2019Publication date: October 7, 2021Inventors: Rolf Albach, Torsten Hagen, Torsten Heinemann, Nicole Welsch
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Publication number: 20210163662Abstract: The invention relates to a process for producing polyurethane/polyisocyanurate rigid foams by reacting a specific reaction mixture in the presence of a catalyst component containing potassium formate and to the polyurethane/polyisocyanurate rigid foams produced according to said method.Type: ApplicationFiled: April 9, 2019Publication date: June 3, 2021Inventors: Ralf Koester, Nicole Welsch, Rene Abels, Inge Tinnefeld
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Publication number: 20210163663Abstract: The invention relates to a process for producing polyurethane/polyisocyanurate rigid foams by reacting a specific reaction mixture in the presence of a catalyst component containing potassium formate and an amine, and to the polyurethane/polyisocyanurate rigid foams produced according to said method.Type: ApplicationFiled: April 9, 2019Publication date: June 3, 2021Inventors: Nicole Welsch, Ralf Koester, Rene Abels, Inge Tinnefeld
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Patent number: 10836858Abstract: The invention relates to a method for producing polyether carbonate polyols by adding alkylene oxides and carbon dioxide to an H-functional starter substance in the presence of a double metal cyanide (DMC) catalyst or in the presence of a metal complex catalyst based on the metals zinc and/or cobalt, wherein (?) alkylene oxide and carbon dioxide are added to an H-functional starter substance in a reactor with a total pressure (absolute) of 5 to 120 bar in the presence of a double metal cyanide catalyst or in the presence of a metal complex catalyst based on the metals zinc and/or cobalt, and a reaction mixture containing the polyether carbonate polyol is obtained, (?) the reaction mixture obtained in step (?) remains in the reactor or is optionally continuously transferred to a downstream reactor at a starting total pressure (absolute) of 5 to 120 bar, the content of free alkylene oxide in the reaction mixture being reduced in the course of a downstream reaction in each case, and the total pressure (absolute)Type: GrantFiled: June 20, 2017Date of Patent: November 17, 2020Assignee: Covestro Deutschland AGInventors: Jörg Hofmann, Urs Rauwald, Stefanie Braun, Matthias Wohak, Hartmut Nefzger, Nicole Welsch, Aurel Wolf, Michael Traving, Lars Krueger
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Publication number: 20190367770Abstract: The invention relates to a process for producing rigid polyurethane (PUR) and polyurethane/polyisocyanurate (PUR/PIR) foams, comprising the steps of i) producing a reaction mixture containing the components A) an isocyanate-reactive component, B) a polyisocyanate component, and C) a blowing agent, and ii) applying the reaction mixture by using a system comprising at least one casting device. The casting device (100) having: a supply port (12) for feeding the reaction mixture (10), at least one discharge gap (13) extending in a transverse direction (Q) for the discharge of the reaction mixture (10), two gap-forming plates (14) arranged opposite one another, a gap space (15) extending between the gap-forming plates (14) above the discharge gap (13) in a height direction (H), wherein the reaction mixture can be introduced into the gap space (15), distributed over the length of the supply duct (16).Type: ApplicationFiled: January 30, 2018Publication date: December 5, 2019Inventors: Dirk Brüning, Achim Symannek, Stephan Schleiermacher, Dirk Steinmeister, Catherine Loevenich, Nicole Welsch
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Publication number: 20190322801Abstract: The invention relates to a method for producing polyether carbonate polyols by adding alkylene oxides and carbon dioxide to an H-functional starter substance in the presence of a double metal cyanide (DMC) catalyst or in the presence of a metal complex catalyst based on the metals zinc and/or cobalt, wherein (?) alkylene oxide and carbon dioxide are added to an H-functional starter substance in a reactor with a total pressure (absolute) of 5 to 120 bar in the presence of a double metal cyanide catalyst or in the presence of a metal complex catalyst based on the metals zinc and/or cobalt, and a reaction mixture containing the polyether carbonate polyol is obtained, (?) the reaction mixture obtained in step (?) remains in the reactor or is optionally continuously transferred to a downstream reactor at a starting total pressure (absolute) of 5 to 120 bar, the content of free alkylene oxide in the reaction mixture being reduced in the course of a downstream reaction in each case, and the total pressure (absolute)Type: ApplicationFiled: June 20, 2017Publication date: October 24, 2019Inventors: Jörg HOFMANN, Urs RAUWALD, Stefanie BRAUN, Matthias WOHAK, Hartmut NEFZGER, Nicole WELSCH, Aurel WOLF, Michael TRAVING, Lars KRUEGER
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Publication number: 20190224333Abstract: Ultra-low crosslinked microgels made of an ultra-low crosslinked polymer are provided. The microgels, also referred to as Platelet-like Particles (PLPs), preferably have <0.5% crosslinking densities. One or more of the polymers are conjugated with a fibrin-binding element or moiety, preferably H6, in an amount effective to confer to the microgel selective binding to fibrin under physiological conditions. The PLPs can recapitulate multiple key functions of platelets including binding, stabilizing and enhancing fibrin clot formation, responsiveness to injury cues, and induction of clot contraction. In a preferred embodiment, the microgel or PLP has little or no binding to soluble fibrinogen under physiological conditions compared to its binding to fibrin. The microgels or PLPs are prepared using crosslinker-free synthesis conditions, and can promote or induce clotting and clot contraction.Type: ApplicationFiled: February 4, 2019Publication date: July 25, 2019Inventors: Thomas H. Barker, Ashley Carson Brown, Louis Andrew Lyon, Sarah E. Stabenfeldt, Nicole Welsch, John Nicosia
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Patent number: 10195304Abstract: Ultra-low crosslinked microgels made of an ultra-low crosslinked polymer are provided. The microgels, also referred to as Platelet-like Particles (PLPs), preferably have <0.5% crosslinking densities. One or more of the polymers are conjugated with a fibrin-binding element or moiety, preferably H6, in an amount effective to confer to the microgel selective binding to fibrin under physiological conditions. The PLPs can recapitulate multiple key functions of platelets including binding, stabilizing and enhancing fibrin clot formation, responsiveness to injury cues, and induction of clot contraction. In a preferred embodiment, the microgel or PLP has little or no binding to soluble fibrinogen under physiological conditions compared to its binding to fibrin. The microgels or PLPs are prepared using crosslinker-free synthesis conditions, and can promote or induce clotting and clot contraction.Type: GrantFiled: November 11, 2014Date of Patent: February 5, 2019Assignee: Georgia Tech Research CorporationInventors: Thomas H. Barker, Ashley Carson Brown, Louis Andrew Lyon, Sarah E. Stabenfeldt, Nicole Welsch
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Publication number: 20180273674Abstract: The present invention relates to a method for producing polyurethane foams by reacting an isocyanate component with an isocyanate-reactive component comprising at least one polyethercarbonate polyol, the reaction taking place in the presence of a component K selected from one or more compounds from the group consisting of K1 esters of mono- or polybasic carboxylic acids whose (first) dissociation has a pKa of 0.5 to 4.0, K2 mono-, di- and polysulfonates of mono- and polyfunctional alcohols, and K3 one or more compounds from the group consisting of K 3.1 esters of phosphoric acid, phosphonic acid, phosphorous acid, phosphinic acid, phosphonous acid and phosphinous acid, these esters each containing no P—OH group, K3.Type: ApplicationFiled: December 6, 2016Publication date: September 27, 2018Inventors: Bert Klesczewski, Jörg Hofmann, Karsten Malsch, Nicole Welsch, Klaus Lorenz, Hartmut Nefzger, Kai Laemmerhold
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Publication number: 20160271292Abstract: Ultra-low crosslinked microgels made of an ultra-low crosslinked polymer are provided. The microgels, also referred to as Platelet-like Particles (PLPs), preferably have <0.5% crosslinking densities. One or more of the polymers are conjugated with a fibrin-binding element or moiety, preferably H6, in an amount effective to confer to the microgel selective binding to fibrin under physiological conditions. The PLPs can recapitulate multiple key functions of platelets including binding, stabilizing and enhancing fibrin clot formation, responsiveness to injury cues, and induction of clot contraction. In a preferred embodiment, the microgel or PLP has little or no binding to soluble fibrinogen under physiological conditions compared to its binding to fibrin. The microgels or PLPs are prepared using crosslinker-free synthesis conditions, and can promote or induce clotting and clot contraction.Type: ApplicationFiled: November 11, 2014Publication date: September 22, 2016Inventors: Thomas H. Barker, Ashley Carson Brown, Louis Andrew Lyon, Sarah E. Stabenfeldt, Nicole Welsch