Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (1) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (1).

Abstract: The present disclosure provides methods for treating a subject having a HER2 non-amplified (HER2-negative) cancer or low HER2 expressing (HER2-low) cancer, comprising detecting expression of a BCAR4 gene fusion in a biological sample from the subject. If expression of the BCAR4 gene fusion is detected, a HER2-targeted cancer treatment is administered to the subject; if expression of the BCAR4 gene fusion is not detected, a cancer treatment that is not HER2-targeted is administered to the subject. Methods of predicting response to a HER2-targeted cancer treatment and detecting BCAR4 or BCAR4 gene fusion activation are also provided.

Abstract: A method of producing aroma enhanced gas for use in a beverage making machine, to make a beverage, includes producing an enhanced aroma solid gas source using at least an enhancing compound as part of an ingredient, forming an aroma precipitate through conversion of an aroma vapor released during a preparation process which utilizes at least the ingredient, and mixing predefined ratio of the aroma precipitate with a solid gas source to form an aroma enhanced solid gas source. Exemplary embodiments include allowing the aroma enhanced solid gas source to sublimate emitting an aroma enhanced gas, dissolving a portion of the aroma enhanced gas into the beverage diluent liquid, and mixing the beverage diluent liquid in predefined ratio with at least one of a beverage ingredient to form a beverage.