Patents by Inventor Nicole Zimmerman

Nicole Zimmerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ION CHANNEL MODULATORS AND METHODS OF USE
    Publication number: 20130345208
    Abstract: In general, the invention relates to novel 4-phenylpyrimidine compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels for the treatment of pain.
    Type: Application
    Filed: August 23, 2013
    Publication date: December 26, 2013
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: ESTHER MARTINBOROUGH, Nicole Zimmerman, Robert B. Perni, Michael Arnost, Upul K. Bandarage, Francois Maltais, Guy Bemis
  • COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS
    Publication number: 20120238578
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: May 23, 2012
    Publication date: September 20, 2012
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Jesus E. Gonzalez, III, Andreas P. Termin, Esther Martinborough, Nicole Zimmerman
  • Compositions useful as inhibitors of voltage-gated sodium channels
    Patent number: 8202861
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: June 19, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus E Gonzales, III, Andreas P Termin, Esther Martinborough, Nicole Zimmerman
  • COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED ION CHANNELS
    Publication number: 20120040935
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: May 18, 2011
    Publication date: February 16, 2012
    Applicant: Vertex Pharmaceuticals, Inc.
    Inventors: Dean M. Wilson, Andreas P. Termin, Timothy D. Neubert, Jian Wang, Yulian Zhang, Jesus E. Gonzalez, III, Esther Martinborough, Nicole Zimmerman
  • Compositions useful as inhibitors of voltage-gated ion channels
    Patent number: 7968545
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: August 5, 2004
    Date of Patent: June 28, 2011
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Dean M. Wilson, Andreas P. Termin, Timothy D. Neubert, Jian Wang, Yulian Zhang, Jesus E. Gonzalez, III, Esther Martinborough, Nicole Zimmerman
  • Heterocyclic derivatives for modulation of calcium channels
    Patent number: 7888384
    Abstract: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: February 15, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Andreas Termin, Esther Martinborough, Nicole Zimmerman, Charles Cohen, Corey Gutierrez
  • PYRIMIDINES USEFUL AS MODULATORS OF VOLTAGE-GATED ION CHANNELS
    Publication number: 20110003814
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: September 8, 2010
    Publication date: January 6, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Dean Mitchell Wilson, Esther Martinborough, Timothy Donald Neubert, Andreas Peter Termin, Jesus E. Gonzalez, III, Nicole Zimmerman
  • Pyrimidines useful as modulators of voltage-gated ion channels
    Patent number: 7816529
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: October 19, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Mitchell Wilson, Esther Martinborough, Timothy Donald Neubert, Andreas Peter Termin, Jesus E. Gonzalez, III, Nicole Zimmerman
  • QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS
    Publication number: 20100160316
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: March 1, 2010
    Publication date: June 24, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Jesus E. Gonzalez, III, Dean M. Wilson, Andreas P. Termin, Peter D. J. Grootenhuis, Yulian Zhang, Benjamin J. Petzoldt, Lev Tyler Dewey Fanning, Timothy D. Neubert, Roger D. Tung, Esther Martinborough, Nicole Zimmerman
  • Quinazolines useful as modulators of ion channels
    Patent number: 7713983
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: May 11, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus E. Gonzalez, III, Dean M. Wilson, Andreas P. Termin, Peter D. J. Grootenhuis, Yulian Zhang, Benjamin J. Petzoldt, Lev Tyler Dewey Fanning, Timothy D. Neubert, Roger D. Tung, Esther Martinborough, Nicole Zimmerman
  • Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels
    Publication number: 20100087479
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: September 10, 2009
    Publication date: April 8, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Jesus E. Gonzalez, III, Andreas P. Termin, Esther Martinborough, Nicole Zimmerman
  • Quinazolines useful as modulators of ion channels
    Patent number: 7678802
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: March 16, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus E. Gonzalez, III, Dean Mitchell Wilson, Andreas Peter Termin, Peter Diederik Jan Grootenhuis, Yulian Zhang, Benjamin John Petzoldt, Lev Tyler Dewey Fanning, Timothy Donald Neubert, Roger Tung, Esther Martinborough, Nicole Zimmerman
  • Compositions useful as inhibitors of voltage-gated sodium channels
    Patent number: 7615563
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: November 10, 2009
    Inventors: Jesus E. Gonzalez, III, Andreas P. Termin, Esther Martinborough, Nicole Zimmerman
  • HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS
    Publication number: 20090253682
    Abstract: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
    Type: Application
    Filed: April 16, 2009
    Publication date: October 8, 2009
    Inventors: Andreas Termin, Esther Martinborough, Nicole Zimmerman, Charles Cohen, Corey Gutierrez
  • Heterocyclic derivatives for modulation of calcium channels
    Patent number: 7569604
    Abstract: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: August 4, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Andreas Termin, Esther Martinborough, Nicole Zimmerman, Charles Cohen, Corey Gutierrez
  • ION CHANNEL MODULATORS AND METHODS OF USE
    Publication number: 20080293737
    Abstract: In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
    Type: Application
    Filed: May 21, 2008
    Publication date: November 27, 2008
    Inventors: Esther Martinborough, Tim Neubert, Tara Whitney, Danielle Lehsten, Tara Hampton, Nicole Zimmerman, Andreas P. Termin
  • Quinazolines useful as modulators of ion channels
    Publication number: 20060217377
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: September 2, 2004
    Publication date: September 28, 2006
    Inventors: Jesus Gonzalez, Dean Wilson, Andreas Termin, Peter Grootenhuis, Yulian Zhang, Benjamin Petzoldt, Lev Fanning, Timothy Neubert, Roger Tung, Esther Martinborough, Nicole Zimmerman
  • Heterocyclic derivatives for modulation of calcium channels
    Publication number: 20060074076
    Abstract: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
    Type: Application
    Filed: June 22, 2005
    Publication date: April 6, 2006
    Inventors: Andreas Termin, Esther Martinborough, Nicole Zimmerman, Charles Cohen, Corey Gutierrez
  • Compositions useful as inhibitors of voltage-gated sodium channels
    Publication number: 20060025415
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: February 17, 2005
    Publication date: February 2, 2006
    Inventors: Jesus Gonzalez, Andreas Termin, Esther Martinborough, Nicole Zimmerman
  • Compositions useful as inhibitors of voltage-gated ion channels
    Publication number: 20050187217
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: August 5, 2004
    Publication date: August 25, 2005
    Inventors: Dean Wilson, Andreas Termin, Timothy Neubert, Jian Wang, Yulian Zhang, Jesus Gonzalez, Esther Martinborough, Nicole Zimmerman