Patents by Inventor Nicos D. Christofides

Nicos D. Christofides has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for measuring the free fraction of ligands in biological fluids
    Patent number: 5278080
    Abstract: A one-step assay for the free portion of a ligand in a biological sample involves incubating a mixture of the sample with a labelled antibody for the ligand and a ligand analogue which competes with the ligand for binding to the antibody. The assay is characterized by choosing a ligand analogue which has a lower affinity for the antibody than does the ligand. An insolubilised ligand analogue preferably has a binding affinity for the antibody from 0.01% to 10% of that of the ligand. Ligand/ligand analogue pairs exemplified are T4/T3 (Thyroxine/Tri- iodothyronine); Testosterone/etiocholanol; and T3/T2.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: January 11, 1994
    Assignee: Amersham International PLC
    Inventors: John E. Midgley, Christopher P. Sheehan, Nicos D. Christofides