Abstract: The present invention relates to oligomeric compounds and conjugates thereof that target Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) PCSK9 mRNA in a cell, leading to reduced expression of PCSK9. Reduction of PCSK9 expression is beneficial for a range of medical disorders, such as hypercholesterolemia and related disorders.

Abstract: The present invention relates to a pocket spring core (40). The pocket spring core (40) comprises a plurality of pocketed spring elements (41). Each of the plurality of pocketed spring elements (41) is formed of a pocket (42) and at least one coil spring (43) enclosed by the pocket (42). The pocket spring core (40) comprises furthermore a frame element (44) enclosing an arrangement of the plurality of pocketed spring elements (41) along a circumference of the arrangement. The frame element (44) is glued to several pockets (42) of the plurality of pocketed spring elements (41) using a hot melt adhesive, a polyurethane adhesive or an epoxy lime adhesive.

Abstract: The present invention relates to a pocket spring core (40). The pocket spring core (40) comprises a plurality of pocketed spring elements (41). Each of the plurality of pocketed spring elements (41) is formed of a pocket (42) and at least one coil spring (43) enclosed by the pocket (42). The pocket spring core (40) comprises furthermore a frame element (44) enclosing an arrangement of the plurality of pocketed spring elements (41) along a circumference of the arrangement. The frame element (44) is glued to several pockets (42) of the plurality of pocketed spring elements (41) using a hot melt adhesive, a polyurethane adhesive or an epoxy lime adhesive.

Abstract: A pocketed spring unit comprises a first pocketed spring (11), a second pocketed spring (12) arranged inside the first pocketed spring (11), and a third pocketed spring (13) arranged inside the second pocketed spring (12).

Abstract: A pocket spring core for a bedding or seating cushion comprises an array of pocket springs. The array of pocket springs comprises fully active springs (10) respectively enclosed in an associated pocket (35) of fabric. Each fully active spring (10) respectively has a central spiral portion (20) with at least one turn and defining a spring axis (13), an unknotted first end turn (21) defining a first end of the fully active spring (10), and an unknotted second end turn (22) defining an opposing second end of the fully active spring (10). Each fully active spring (10) has a rest shape in which the first end turn (21) and the second end turn (22) have a finite pitch angle, so that the first end turn (21) and the second end turn (22) contribute to a spring force of the fully active spring (10).

Abstract: A pocket spring core for a bedding or seating cushion comprises an array of pocket springs. The array of pocket springs comprises fully active springs (10) respectively enclosed in an associated pocket (35) of fabric. Each fully active spring (10) respectively has a central spiral portion (20) with at least one turn and defining a spring axis (13), an unknotted first end turn (21) defining a first end of the fully active spring (10), and an unknotted second end turn (22) defining an opposing second end of the fully active spring (10). Each fully active spring (10) has a rest shape in which the first end turn (21) and the second end turn (22) have a finite pitch angle, so that the first end turn (21) and the second end turn (22) contribute to a spring force of the fully active spring (10).