Patents by Inventor Niels Christian Kaarsholm

Niels Christian Kaarsholm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Soluble, stable insulin-containing formulations with a protamine salt
    Patent number: 8263551
    Abstract: The present invention relates to pharmaceutical formulations comprising insulin, an insulin analog, an insulin derivative, or a combination of any of the foregoing, and a salt of protamine, to methods of preparing such formulations, and to uses of such formulations in the treatment of diseases and conditions for which use of the insulin peptide(s) contained in such formulations is indicated. The present invention further relates to methods for increasing the stability and/or solubility of insulin in insulin-containing formulations at a pH less than 7.0 by adding a salt of protamine to the insulin-containing formulations.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: September 11, 2012
    Assignee: Novo Nordisk A/S
    Inventors: Helle Birk Olsen, Niels Christian Kaarsholm, Per Balschmidt
  • Soluble, Stable Insulin-Containing Formulations with a Protamine Salt
    Publication number: 20110046049
    Abstract: The present invention relates to pharmaceutical formulations comprising insulin, an insulin analog, an insulin derivative, or a combination of any of the foregoing, and a salt of protamine, to methods of preparing such formulations, and to uses of such formulations in the treatment of diseases and conditions for which use of the insulin peptide(s) contained in such formulations is indicated. The present invention further relates to methods for increasing the stability and/or solubility of insulin in insulin-containing formulations at a pH less than 7.0 by adding a salt of protamine to the insulin-containing formulations.
    Type: Application
    Filed: November 21, 2005
    Publication date: February 24, 2011
    Applicant: NOVO NORDISK A/S
    Inventors: Helle Birk Olsen, Niels Christian Kaarsholm, Per Balschmidt
  • Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand
    Publication number: 20090123563
    Abstract: Novel preparations comprising branched ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer. The preparations have a prolonged action designed for flexible injection regimes.
    Type: Application
    Filed: February 6, 2006
    Publication date: May 14, 2009
    Applicant: NOVO NORDISK A/S
    Inventors: Niels Christian Kaarsholm, Helle Birk Olsen, Peter Madsen, Soeren Ostegaard, Palle Jakobsen, Tina Moeller Tagmose
  • GLP-2 compounds, formulations, and uses thereof
    Patent number: 7411039
    Abstract: The present invention relates to novel human glucagon-like peptide-2 (GLP-2) peptides and human glucagon-like peptide-2 derivatives which have a protracted profile of action as well as polynucleotide constructs encoding such peptides, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: August 12, 2008
    Assignee: Novo Nordisk A/S
    Inventors: Lars Thim, Susanne Bang, Niels Christian Kaarsholm, Anette Sams Nielsen, Nils Langeland Johansen, Kjeld Madsen, Magali Zundel, Peter Thygesen, Birgitte Michelsen
  • Insulin derivatives
    Patent number: 7229964
    Abstract: The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the ?-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have a protracted profile of action.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: June 12, 2007
    Assignee: Novo Nordisk A/S
    Inventors: Jan Markussen, Ib Jonassen, Svend Havelund, Jakob Brandt, Peter Kurtzhals, Per Hertz Hansen, Niels Christian Kaarsholm
  • GLP-2 compounds, formulations, and uses thereof
    Publication number: 20040122210
    Abstract: The present invention relates to novel human glucagon-like peptide-2 (GLP-2) peptides and human glucagon-like peptide-2 derivatives which have a protracted profile of action as well as polynucleotide constructs encoding such peptides, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.
    Type: Application
    Filed: October 14, 2003
    Publication date: June 24, 2004
    Inventors: Lars Thim, Susanne Bang, Morten Schlein, Niels Christian Kaarsholm, Dorthe Kot Engelund, Anette Sams Nielsen, Nils Langeland Johansen, Kjeld Madsen, Magali Zundel, Peter Thygesen
  • Insulin derivatives
    Publication number: 20040067874
    Abstract: The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the &agr;-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have a protracted profile of action.
    Type: Application
    Filed: July 16, 2003
    Publication date: April 8, 2004
    Inventors: Jan Markussen, Ib Jonassen, Svend Havelund, Jakob Brandt, Peter Kurtzhals, Per Hertz Hansen, Niels Christian Kaarsholm
  • Insulin derivatives
    Patent number: 6620780
    Abstract: The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the &agr;-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have a protracted profile of action.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: September 16, 2003
    Assignee: Novo Nordisk A/S
    Inventors: Jan Markussen, Ib Jonassen, Svend Havelund, Jakob Brandt, Peter Kurtzhals, Per Hertz Hansen, Niels Christian Kaarsholm
  • Insulin derivatives
    Publication number: 20020193292
    Abstract: The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the &agr;-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have a protracted profile of action.
    Type: Application
    Filed: May 21, 2001
    Publication date: December 19, 2002
    Inventors: Jan Markussen, Ib Jonassen, Svend Havelund, Jakob Brandt, Peter Kurtzhals, Per Hertz Hansen, Niels Christian Kaarsholm
  • Insulin derivatives
    Patent number: 6251856
    Abstract: The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the &agr;-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have a protracted profile of action.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: June 26, 2001
    Assignee: Novo Nordisk A/S
    Inventors: Jan Markussen, Ib Jonassen, Svend Havelund, Jakob Brandt, Peter Kurtzhals, Per Hertz Hansen, Niels Christian Kaarsholm