Abstract: The present invention relates to an apparatus having a nanodevice (1) for controlling the flow of charged particles in an electrolyte. Such apparatus comprises an electrolytic bath container (2) divided by a polymeric membrane foil (3) into a first (4) and a second compartment (5), wherein each compartment (4, 5) comprises an electrode (6, 7) connected to a voltage supply (8). Further the apparatus comprises at least one asymmetric pore (9) forming a via hole through said foil (3), wherein said pore (9) provides a narrow opening (10) of a diameter in the range of several nanometers down to about one nanometer on a front side (11) of said foil (3) and a wide opening (12) in the range of several ten nanometers up to several hundred nanometers on a back side (13) of said foil (3).

Abstract: The invention relates to a collection (kit-of-parts) for producing a high electrical resistance in an electrophysiological examination of a membrane comprising an ion channel, comprising a first electrolytic solution and a second electrolytic solution, wherein the first electrolytic solution comprises 20-140 mM divalent cations of a first element and the second electrolytic solution comprises 20-200 mM monovalent anions of a second element.

Abstract: The present invention relates to an apparatus having a nanodevice (1) for controlling the flow of charged particles in an electrolyte. Such apparatus comprises an electrolytic bath container (2) divided by a polymeric membrane foil (3) into a first (4) and a second compartment (5), wherein each compartment (4, 5) comprises an electrode (6, 7) connected to a voltage supply (8). Further the apparatus comprises at least one asymmetric pore (9) forming a via hole through said foil (3), wherein said pore (9) provides a narrow opening (10) of a diameter in the range of several nanometers down to about one nanometer on a front side (11) of said foil (3) and a wide opening (12) in the range of several ten nanometers up to several hundred nanometers on a back side (13) of said foil (3).

Abstract: The present invention relates to devices and methods for analyzing ion channels in membranes. The invention is characterized by a biochip comprising a substrate in which openings are provided in the form of an M×N matrix for receiving therein a cell membrane including at least one ion channel (I) or an artificial lipid membrane (Me), wherein M?1 and N?1.

Abstract: The present invention relates to an apparatus having a nanodevice for controlling the flow of charged particles in an electrolyte. Such apparatus comprises an electrolytic bath container divided by a polymeric foil into a first and a second compartment, wherein each compartment comprises an electrode connected to a voltage supply. Further the apparatus comprises at least one asymmetric pore forming a via hole through said foil, wherein said pore provides a narrow opening of a diameter in the range of several nanometers down to about one nanometer on a front side of said foil and a wide opening in the range of several ten nanometers up to several hundred nanometers on a back side of said foil.