Patents by Inventor Niels Kristian Bau-Madsen
Niels Kristian Bau-Madsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11779919Abstract: A microfluidic system includes a microfluidic cartridge and a detector assembly. The microfluidic cartridge includes a first and second side and at least one flow channel and an inlet to flow channel(s) for feeding a liquid sample, the flow channel(s) includes a plurality of first optical detection sites. The detector assembly includes a slot. The detector assembly and the microfluidic cartridge are constructed such that when the microfluidic cartridge is inserted to a first predetermined position into the slot, one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source, and when the cartridge is inserted to a second predetermined position into the slot, another one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source.Type: GrantFiled: March 13, 2019Date of Patent: October 10, 2023Assignee: ZOETIS DENMARK APSInventors: Niels Kristian Bau-Madsen, Lars Bue Nielsen, Martin Heller, Ole Kring, Olga Ordeig, Bent Overby
-
Patent number: 11474034Abstract: A lateral flow test system having an optical reader, a lateral flow cartridge and a computer system is provided. The lateral flow cartridge includes a porous test strip with a reading window into the porous test strip exposing an exposed zone of the porous strip. The optical reader has a reader housing and a slot for inserting the cartridge into the reader housing. The optical reader has an illumination arrangement adapted for illuminating the exposed zone of the porous strip when the cartridge is inserted into the slot. The optical reader further has a video camera configured for acquiring a series of digital images comprising the exposed zone of the porous strip. The computer system receives sets of pixel data representing the plurality of consecutive digital images and calculates wetting progress along the length of the exposed zone of the porous strip based on the sets of pixels data.Type: GrantFiled: March 9, 2018Date of Patent: October 18, 2022Assignee: Zoetis Services LLCInventors: Carl Esben Poulsen, Johan Eriksen, Martin Heller, Niels Kristian Bau-Madsen
-
Patent number: 11400449Abstract: A microfluidic assay system including a microfluidic cartridge and an associated microfluidic operator system. The microfluidic cartridge comprises a base part, having a first face with a recess and a foil fixed to the base part for covering the recess and providing a microfluidic cartridge foil face. The base part with the recess and the foil forms a flow channel and a sink in fluid communication with each other. The microfluidic cartridge comprises an inlet opening into the flow channel upstream to the reaction section.Type: GrantFiled: January 31, 2017Date of Patent: August 2, 2022Assignee: ZOETIS DENMARK APSInventors: Niels Kristian Bau-Madsen, Bent Overby
-
Patent number: 11193949Abstract: A diagnostic test reader system including two or more reader modules and at least one mother module is provided. Each of the reader modules includes a unique code and is configured for reading a specific test cartridge type. Each of the reader modules is configured to be in data communication with the mother module for receiving instructions from the mother module and for transmitting read and/or derived data to the mother module. The mother module is configured for communicating individually with each of the reader modules.Type: GrantFiled: February 13, 2018Date of Patent: December 7, 2021Assignee: Zoetis Services LLCInventors: Niels Kristian Bau-Madsen, Ole Kring
-
Publication number: 20210187501Abstract: A microfluidic assay system including a microfluidic cartridge and an associated microfluidic operator system. The microfluidic cartridge comprises a base part, having a first face with a recess and a foil fixed to the base part for covering the recess and providing a microfluidic cartridge foil face. The base part with the recess and the foil forms a flow channel and a sink in fluid communication with each other. The microfluidic cartridge comprises an inlet opening into the flow channel upstream to the reaction section.Type: ApplicationFiled: January 31, 2017Publication date: June 24, 2021Applicant: Scandinavian Micro Biodevices ApSInventors: Niels Kristian BAU-MADSEN, Bent OVERBY
-
Publication number: 20210063388Abstract: A method and a system for quantitative or qualitative determination of a target component in a liquid sample. The method includes i) providing a plurality of magnetic particles including capture sites for the target component on their respective surfaces; ii) providing a plurality of fluorophores configured to bind to the capture sites of the magnetic particles; iii) bringing the liquid sample into contact with the fluorophores and the magnetic particles in a flow channel of a micro fluidic device including a transparent window; and iv) at least temporally immobilizing the magnetic particles adjacent to the transparent window using a magnet, emitting exciting electromagnetic beam towards the immobilized magnetic particles, reading signals emitted from fluorophores and performing a quantitative or qualitative determination of the target component based on the read signal. A suitable micro fluidic device for use in the method/system and a kit for preparing a liquid sample.Type: ApplicationFiled: November 5, 2020Publication date: March 4, 2021Applicant: Zoetis Denmark ApSInventors: Bent Overby, Niels Kristian Bau-Madsen, Martin Bak Heller
-
Patent number: 10859571Abstract: A method and a system for quantitative or qualitative determination of a target component in a liquid sample includes i) providing a plurality of magnetic particles including one or more capture sites for the target component on their respective surfaces; ii) providing a plurality of fluorophores configured to bind to the capture sites of the magnetic particles; iii) bringing the liquid sample into contact with the fluorophores and the magnetic particles in a flow channel of a micro fluidic device including a transparent window; and iv) at least temporally immobilizing the magnetic particles adjacent to the transparent window using a magnet, emitting exciting electromagnetic beam towards the immobilized magnetic particles, reading signals emitted from fluorophores captured by the immobilized magnetic particles and performing a quantitative or qualitative determination of the target component based on the read signal.Type: GrantFiled: June 21, 2013Date of Patent: December 8, 2020Assignee: ZOETIS DENMARK ApSInventors: Martin Bak Heller, Bent Overby, Niels Kristian Bau-Madsen
-
Patent number: 10521742Abstract: The invention comprises a system for collecting batches of food from food suppliers. The system comprises at least one movable collecting unit with an associated data receiver; a food parameter determining system for determining at least one batch parameter of a collected food batch; a database system for storing food supplier data comprising at least one food collecting address identification for each food supplier, food receiver data comprising at least one food delivering address identification for each of at least one food receiver station and reference data comprising threshold data for said at least one batch parameter or derived parameter correlated to said batch parameter. The system further comprises a server system coupled to said database system and being in data communication with said data receiver. The server system receives at least data from the database system and batch parameter data and calculates logistic plan(s) for the movable collecting unit(s).Type: GrantFiled: January 17, 2017Date of Patent: December 31, 2019Assignee: SCANDINAVIAN MICRO BIODEVICES APSInventors: Ole Kring, Bent Overby, Martin Heller, Niels Kristian Bau-Madsen, Lars Mogensen
-
Publication number: 20190210022Abstract: A microfluidic system includes a microfluidic cartridge and a detector assembly. The microfluidic cartridge includes a first and second side and at least one flow channel and an inlet to flow channel(s) for feeding a liquid sample, the flow channel(s) includes a plurality of first optical detection sites. The detector assembly includes a slot. The detector assembly and the microfluidic cartridge are constructed such that when the microfluidic cartridge is inserted to a first predetermined position into the slot, one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source, and when the cartridge is inserted to a second predetermined position into the slot, another one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source.Type: ApplicationFiled: March 13, 2019Publication date: July 11, 2019Applicant: SCANDINAVIAN MICRO BIODEVICES APSInventors: Niels Kristian Bau-Madsen, Lars Bue Nielsen, Martin Heller, Ole Kring, Olga Ordeig, Bent Overby
-
Patent number: 10307754Abstract: A microfluidic cartridge includes first and second sides and at least one flow channel and an inlet to the flow channel(s) for feeding a liquid sample, the flow channel(s) include a plurality of first optical detection sites. A detector assembly includes a slot for inserting the microfluidic cartridge and a first fixed light source with a beam path and an optical reader for reading out optical signals from at least one of the first optical detection site(s). When the microfluidic cartridge is inserted to a first predetermined position into the slot, one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source, and when the cartridge is inserted to a second predetermined position into the slot, another one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source.Type: GrantFiled: June 15, 2015Date of Patent: June 4, 2019Assignee: SCANDINAVIAN MICRO BIODEVICES APSInventors: Niels Kristian Bau-Madsen, Lars Bue Nielsen, Martin Heller, Ole Kring, Olga Ordeig, Bent Overby
-
Publication number: 20190026662Abstract: The invention comprises a system for collecting batches of food from food suppliers. The system comprises at least one movable collecting unit with an associated data receiver; a food parameter determining system for determining at least one batch parameter of a collected food batch; a database system for storing food supplier data comprising at least one food collecting address identification for each food supplier, food receiver data comprising at least one food delivering address identification for each of at least one food receiver station and reference data comprising threshold data for said at least one batch parameter or derived parameter correlated to said batch parameter. The system further comprises a server system coupled to said database system and being in data communication with said data receiver. The server system receives at least data from the database system and batch parameter data and calculates logistic plan(s) for the movable collecting unit(s).Type: ApplicationFiled: January 17, 2017Publication date: January 24, 2019Applicants: SCANDINAVIAN MICRO BIODEVICES APS, CHR. HANSEN A/SInventors: Ole Kring, Bent Overby, Martin Heller, Niels Kristian Bau-Madsen, Lars Mogensen
-
Publication number: 20180259449Abstract: A lateral flow test system having an optical reader, a lateral flow cartridge and a computer system is provided. The lateral flow cartridge includes a porous test strip with a reading window into the porous test strip exposing an exposed zone of the porous strip. The optical reader has a reader housing and a slot for inserting the cartridge into the reader housing. The optical reader has an illumination arrangement adapted for illuminating the exposed zone of the porous strip when the cartridge is inserted into the slot. The optical reader further has a video camera configured for acquiring a series of digital images comprising the exposed zone of the porous strip. The computer system receives sets of pixel data representing the plurality of consecutive digital images and calculates wetting progress along the length of the exposed zone of the porous strip based on the sets of pixels data.Type: ApplicationFiled: March 9, 2018Publication date: September 13, 2018Inventors: Carl Esben Poulsen, Johan Eriksen, Martin Heller, Niels Kristian Bau-Madsen
-
Publication number: 20180238918Abstract: A diagnostic test reader system including two or more reader modules and at least one mother module is provided. Each of the reader modules includes a unique code and is configured for reading a specific test cartridge type. Each of the reader modules is configured to be in data communication with the mother module for receiving instructions from the mother module and for transmitting read and/or derived data to the mother module. The mother module is configured for communicating individually with each of the reader modules.Type: ApplicationFiled: February 13, 2018Publication date: August 23, 2018Inventors: Niels Kristian Bau-Madsen, Ole Kring
-
Publication number: 20170203295Abstract: A microfluidic cartridge includes first and second sides and at least one flow channel and an inlet to the flow channel(s) for feeding a liquid sample, the flow channel(s) include a plurality of first optical detection sites. A detector assembly includes a slot for inserting the microfluidic cartridge and a first fixed light source with a beam path and an optical reader for reading out optical signals from at least one of the first optical detection site(s). When the microfluidic cartridge is inserted to a first predetermined position into the slot, one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source, and when the cartridge is inserted to a second predetermined position into the slot, another one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source.Type: ApplicationFiled: June 15, 2015Publication date: July 20, 2017Applicant: SCANDINAVIAN MICRO BIODEVICES APSInventors: Niels Kristian BAU-MADSEN, Lars Bue NIELSEN, Martin HELLER, Ole KRING, Olga ORDEIG, Bent OVERBY
-
Patent number: 9201059Abstract: The invention relates to a microfluidic system comprising a microfluidic device having a first and a second opposite surfaces and an optical detector, the microfluidic device comprises a flow channel with a detection channel section having a length of at least about 1 mm, the microfluidic device comprises at least one aperture section comprising at least a part of said detection channel section and a transparent window into said detection channel section, the optical detector is arranged to determine at least one optical property of said aperture section as a function of time. The flow channel may have capillary dimensions and/or it may wholly or fully be arranged to drive a fluid flow by applying external forces. The microfluid device may be used to determine various properties of a sample fluid, for example it may be used to determine a samples coagulation properties and/or reactions of one or more components in a fluid sample as a function of time.Type: GrantFiled: March 13, 2009Date of Patent: December 1, 2015Assignee: SCANDINAVIAN MICRO BIODEVICES APSInventors: Niels Kristian Bau-Madsen, Jacques Jonsmann, Bent Overby, Christianus Berendsen
-
Publication number: 20150247845Abstract: A method and a system for quantitative or qualitative determination of a target component in a liquid sample includes i) providing a plurality of magnetic particles including one or more capture sites for the target component on their respective surfaces; ii) providing a plurality of fluorophores configured to bind to the capture sites of the magnetic particles; iii) bringing the liquid sample into contact with the fluorophores and the magnetic particles in a flow channel of a micro fluidic device including a transparent window; and iv) at least temporally immobilizing the magnetic particles adjacent to the transparent window using a magnet, emitting exciting electromagnetic beam towards the immobilized magnetic particles, reading signals emitted from fluorophores captured by the immobilized magnetic particles and performing a quantitative or qualitative determination of the target component based on the read signal.Type: ApplicationFiled: June 21, 2013Publication date: September 3, 2015Inventors: Martin Bak Heller, Bent Overby, Niels Kristian Bau-Madsen
-
Patent number: 8877484Abstract: A microfluidic device comprising at least one test channel, which test channel comprises an upper test channel section with an upstream end and a sampling region at its upstream end and at least one reference channel, which reference channel comprises an upper reference channel section with an upstream end and a sampling region at its upstream end. The test channel and the reference channel comprise a merging region downstream to the upper test channel section and a common downstream channel section. The merging region and the common downstream channel section are arranged such that a reference liquid flowing from the upper reference channel section into the merging region will block a test liquid flow in the upper test channel section when the test liquid flow has not yet reached the merging section. The microfluid device may be used for detecting change of flow properties e.g. due to agglomeration, agglutination or viscosity change in a liquid preferably selected from water, urine, blood, or blood plasma.Type: GrantFiled: January 4, 2008Date of Patent: November 4, 2014Assignee: Scandinavian Micro Biodevices APSInventors: Niels Kristian Bau-Madsen, Jacques Jonsmann, Søren Larsen
-
Patent number: 8512648Abstract: A microfluidic device comprising a flow channel with an inlet and a gas escape opening is described. The flow channel comprises a liquid flow channel section and a flow controlling section downstream to the liquid flow channel section and upstream to or coinciding with the gas escape opening. The flow controlling section provides a flow resistance to gas, which is sufficiently high to reduce velocity of a capillary flow of a liquid in the liquid flow channel section. The microfluidic device with the flow controlling section provides a device in which the velocity of the flow can be reduced to a desired level. Also is described a method of performing a test using the microfluidic device.Type: GrantFiled: July 29, 2009Date of Patent: August 20, 2013Assignee: Scandinavian Micro Biodevices APSInventor: Niels Kristian Bau-Madsen
-
Publication number: 20110143383Abstract: A microfluidic device comprising a flow channel with an inlet and a gas escape opening is described. The flow channel comprises a liquid flow channel section and a flow controlling section downstream to the liquid flow channel section and upstream to or coinciding with the gas escape opening. The flow controlling section provides a flow resistance to gas, which is sufficiently high to reduce velocity of a capillary flow of a liquid in the liquid flow channel section. The microfluidic device with the flow controlling section provides a device in which the velocity of the flow can be reduced to a desired level. Also is described a method of performing a test using the microfluidic device.Type: ApplicationFiled: July 29, 2009Publication date: June 16, 2011Applicant: SCANDINAVIAN MICRO BIODEVICES ApSInventors: Jacques Jonsmann, Niels Kristian Bau-Madsen
-
Publication number: 20110045492Abstract: The invention relates to a microfluidic system comprising a microfluidic device having a first and a second opposite surfaces and an optical detector, the microfluidic device comprises a flow channel with a detection channel section having a length of at least about 1 mm, the microfluidic device comprises at least one aperture section comprising at least a part of said detection channel section and a transparent window into said detection channel section, the optical detector is arranged to be in optical communication with said aperture section to determining at least one optical property of said aperture section as a function of time. The flow channel may have capillary dimensions and/or it may wholly or fully be arranged to drive a fluid flow by applying external forces.Type: ApplicationFiled: March 13, 2009Publication date: February 24, 2011Applicant: SCANDINAVIANInventors: Niels Kristian Bau-Madsen, Jacques Jonsmann, Bent Overby, Christianus Berendsen