Patents by Inventor Niels Kristian Klausen

Niels Kristian Klausen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • O-linked glycoforms of polypeptides and method to manufacture them
    Patent number: 10844110
    Abstract: The present invention relates to compositions comprising glycoproteins having altered patterns of O-linked glycosylation, in particular Factor VII, Factor IX, and methods for making these.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: November 24, 2020
    Assignee: Novo Nordisk Healthcare AG
    Inventors: Niels Kristian Klausen, Daniel E. Rasmussen
  • O-Linked Glycoforms Of Polypeptides And Method To Manufacture Them
    Publication number: 20180057566
    Abstract: The present invention relates to compositions comprising glycoproteins having altered patterns of O-linked glycosylation, in particular Factor VII, Factor IX, and methods for making these.
    Type: Application
    Filed: October 9, 2017
    Publication date: March 1, 2018
    Inventors: Niels Kristian Klausen, Daniel E. Rasmussen
  • USE OF GALACTOSE OXIDASE FOR SELECTIVE CHEMICAL CONJUGATION OF PROTRACTOR MOLECULES TO PROTEINS OF THERAPEUTIC INTEREST
    Publication number: 20140274903
    Abstract: This invention relates to novel compounds, methods for selective chemical conjugation of protractor molecules and the use thereof for diagnostic and/or therapeutic purposes.
    Type: Application
    Filed: April 29, 2014
    Publication date: September 18, 2014
    Applicant: NOVO NORDISK HEALTHCARE AG
    Inventors: Carsten Behrens, Patrick W. Garibay, Magali Zundel, Niels Kristian Klausen, Soeren Bjoern
  • Pegylated factor VII glycoforms
    Patent number: 8053410
    Abstract: The invention concerns a preparation comprising a plurality of Factor VII polypeptides or Factor VII-related polypeptides, wherein the polypeptides comprise asparagine-linked and/or serine-linked oligosaccharide chains, and wherein at least one oligosaccharide group is covalently attached to at least one polymeric group.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: November 8, 2011
    Assignee: Novo Nordisk Health Care A/G
    Inventors: Niels Kristian Klausen, Soren Bjorn, Carsten Behrens, Patrick William Garibay
  • Use of Galactose Oxidase for Selective Chemical Conjugation of Protractor Molecules to Proteins of Therapeutic Interest
    Publication number: 20100028939
    Abstract: This invention relates to novel compounds, methods for selective chemical conjugation of protractor molecules and the use thereof for diagnostic and/or therapeutic purposes.
    Type: Application
    Filed: April 1, 2008
    Publication date: February 4, 2010
    Applicant: Novo Nordisk Healthcare A/G
    Inventors: Carsten Behrens, Patrick William Garibay, Magali Zundel, Niels Kristian Klausen, Soren E. Bjorn
  • Method for Producing Factor VII Glycoforms
    Publication number: 20090281022
    Abstract: The present invention provides preparations of Factor VIIa polypeptides or Factor VIIa-related polypeptides that exhibit predetermined glycoform patterns. The preparations of the invention exhibit improved functional properties and are useful for treating Factor VII-mediated conditions.
    Type: Application
    Filed: July 15, 2009
    Publication date: November 12, 2009
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: HANS KURT PINGEL, Niels Kristian Klausen
  • Pegylated Factor VII Glycoforms
    Publication number: 20090227504
    Abstract: The invention concerns a preparation comprising a plurality of Factor VII polypeptides or Factor VII-related polypeptides, wherein the polypeptides comprise asparagine-linked and/or serine-linked oligosaccharide chains, and wherein at least one oligosaccharide group is covalently attached to at least one polymeric group.
    Type: Application
    Filed: February 13, 2009
    Publication date: September 10, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Niels Kristian Klausen, Soren Bjorn, Carsten Behrens, Patrick William Garibay
  • Stabilised Solid Composition of Modified Factor VII
    Publication number: 20090075895
    Abstract: The invention concerns a composition comprising; i) Modified Factor VII; ii) an agent suitable for keeping the pH of said composition in the range of 4 to 7 when said composition is dissolved in water; and iii) a moisture content of at the most 3%.
    Type: Application
    Filed: December 1, 2008
    Publication date: March 19, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Hanne Nedergaard, Lars Linggaard Hansen, Niels Kristian Klausen, Troels Kornfelt, James M. Flink
  • O-Linked Glycoforms Of Polypeptides And Method To Manufacture Them
    Publication number: 20080305518
    Abstract: The present invention relates to compositions comprising glycoproteins having altered patterns of O-linked glycosylation, in particular Factor VII, Factor IX, and methods for making these.
    Type: Application
    Filed: May 3, 2005
    Publication date: December 11, 2008
    Applicant: NOVO NORDISK HEALTHCARE A/G
    Inventors: Niels Kristian Klausen, Daniel Rasmussen
  • Factor VII glycoforms
    Patent number: 6903069
    Abstract: The present invention provides preparations of Factor VIIa polypeptides or Factor VIIa-related polypeptides that exhibit predetermined glycoform patterns. The preparations of the invention exhibit improved functional properties and are useful for treating Factor VII-mediated conditions.
    Type: Grant
    Filed: October 2, 2001
    Date of Patent: June 7, 2005
    Assignee: Novo Nordisk Health Care A/S
    Inventors: Hans Kurt Pingel, Niels Kristian Klausen
  • Stabilised solid compositions of modified factor VII
    Publication number: 20040009918
    Abstract: The invention concerns a composition comprising; i) Modified Factor VII; ii) an agent suitable for keeping the pH of said composition in the range of 4 to 7 when said composition is dissolved in water; and iii) a moisture content of at the most 3%.
    Type: Application
    Filed: May 1, 2003
    Publication date: January 15, 2004
    Inventors: Hanne Nedergaard, Lars Lindgaard Hansen, Niels Kristian Klausen, Troels Kornfelt, James M. Flink
  • Factor VII glycoforms
    Publication number: 20020151471
    Abstract: The present invention provides preparations of Factor VIIa polypeptides or Factor VIIa-related polypeptides that exhibit predetermined glycoform patterns. The preparations of the invention exhibit improved functional properties and are useful for treating Factor VII-mediated conditions.
    Type: Application
    Filed: October 2, 2001
    Publication date: October 17, 2002
    Inventors: Hans Kurt Pingel, Niels Kristian Klausen
  • Factor VII glycoforms
    Publication number: 20020137673
    Abstract: The present invention provides preparations of Factor VIIa polypeptides or Factor VIIa-related polypeptides that exhibit predetermined glycoform patterns. The preparations of the invention exhibit improved functional properties and are useful for treating Factor VII-mediated conditions.
    Type: Application
    Filed: October 2, 2001
    Publication date: September 26, 2002
    Inventors: Hans Kurt Pingel, Niels Kristian Klausen