Abstract: The present invention relates to oligomeric compounds and conjugates thereof that target Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) PCSK9 mRNA in a cell, leading to reduced expression of PCSK9. Reduction of PCSK9 expression is beneficial for a range of medical disorders, such as hypercholesterolemia and related disorders.

Abstract: Wind-driven energy converting device (2) is disclosed. The wind-driven energy converting device (2) comprises a main pendulum (20) comprising a pendulum bob (10) attached to a pendulum rod (6). A sail member (4) attached to the pendulum rod (6) in a higher position than the pendulum rod (6). The main pendulum (20) is suspended in a frame (8) by means of a bearing unit (18) allowing the pendulum rod (6) to be rotated about two perpendicular horizontal axes (X, Y) at the same time. The main pendulum (20) is mechanically attached to at least one secondary pendulum (14) by means of a connection structure (16). The secondary pendulum (14) is connected to and being configured to rotate a driving shaft (36) upon being moved due to motion of the main pendulum (20).

Abstract: Wind-driven energy converting device (2) is disclosed. The wind-driven energy converting device (2) comprises a main pendulum (20) comprising a pendulum bob (10) attached to a pendulum rod (6). A sail member (4) attached to the pendulum rod (6) in a higher position than the pendulum rod (6). The main pendulum (20) is suspended in a frame (8) by means of a bearing unit (18) allowing the pendulum rod (6) to be rotated about two perpendicular horizontal axes (X, Y) at the same time. The main pendulum (20) is mechanically attached to at least one secondary pendulum (14) by means of a connection structure (16). The secondary pendulum (14) is connected to and being configured to rotate a driving shaft (36) upon being moved due to motion of the main pendulum (20).

Abstract: The present invention pertains to a method of producing a compressed nicotine tablet comprising nicotine. The method comprising the steps of adding a first powdered portion of tablet base material into a punch die, pressing said first tablet base material by means of an upper and a lower punch to obtain a first pressed material, inserting an object at the upper face of the first pressed material and fixing the object in a central cavity of the first pressed material, adding a second powdered portion of tablet base material into the punch die, and pressing said first and second tablet base material around the object to enclose the object from the surface of the tablet. The object is based on a material different from the first and/or the second powdered portion of tablet base material.

Abstract: The present invention pertains to a method of producing a compressed tablet in a rotary tablet press. The method including the steps of adding a first powdered portion of tablet base material into a punch die of a rotary tablet press, pressing the first tablet base material by means of an upper and a lower punch to obtain a first pressed material, inserting an object at the upper face of the first pressed material and fixing the object in a central cavity of the first pressed material, adding a second powdered portion of tablet base material into the punch die of the rotary tablet press, and pressing the first and second tablet base material around the object to enclose the object from the surface of the tablet. The object is based on a material different from the first and/or the second powdered portion of tablet base material.

Abstract: A compressed chewing gum tablet including a chewing gum center, the gum center including a compression of gum base granules and chewing gum additives. The chewing gum additives include sweeteners and flavors. At least a first part of the gum base granules have granules of flavor incorporated gum base and at least a second part of the gum base granules have granules of conventional gum base.

Abstract: The invention relates to a method for producing chewing gum granules. The method comprises at least the steps of feeding a gum composition including at least gum base into an extruder (2), pressurizing the gum composition in the extruder, extruding the gum composition through a die plate (5), and cutting the extruded gum composition in a liquid filled chamber (4). Flavor is added to the composition in the extruder prior to the granulation into cooling liquid. The temperature and pressure of the flavored gum composition is controlled so that the temperature is below 70° C. when the pressure is in the range from 1 to 5 hPa.

Abstract: The invention relates to a method for producing chewing gum granules. The method comprises at least the steps of feeding a gum composition including at least gum base into an extruder (2), pressurizing the gum composition in the extruder, extruding the gum composition through a die plate (5), and cutting the extruded gum composition in a liquid filled chamber (4). The extruded gum composition comprises at least 71% Wt. gum base and the cut granules are included in compressed gum tablets. The invention further relates to a chewing gum product, and to a chewing gum granulating system.

Abstract: The invention relates to a method for producing chewing gum granules. The method comprises at least the steps of feeding a gum composition including at least gum base into an extruder (2), pressurizing the gum composition in the extruder, extruding the gum composition through a die plate (5), and cutting the extruded gum composition in a liquid filled chamber (4) so that the cut gum granules have weights per granule in the range of 0.0001 g to 0.

Abstract: The invention relates to a method for producing chewing gum granules. The method comprises at least the steps of feeding a gum composition including at least gum base into an extruder (2), pressurizing the gum composition in the extruder, extruding the gum composition through a die plate (5), and cutting the extruded gum composition in a liquid filled chamber (4) so that the cut gum granules have weights per granule in the range of 0.0001 g to 0.008 g.

Abstract: The invention relates to a chewing gum piece comprising at least one inner filling (2) being enclosed by sugarless chewing gum substance (1), said chewing gum piece being provided with an anti-sticking agent (4), and said chewing gum piece being provided with a coating (6) at least partly encapsulating said chewing gum piece and said anti-sticking agent.

Abstract: The invention relates to a method for producing chewing gum granules. The method comprises at least the steps of feeding a gum composition including at least gum base into an extruder (2), pressurizing the gum composition in the extruder, extruding the gum composition through a die plate (5), and cutting the extruded gum composition in a liquid filled chamber (4). The extruded gum composition comprises at least 71% Wt, gum base and the cut granules are included in compressed gum tablets. The invention further relates to a chewing gum product, and to a chewing gum granulating system.

Abstract: The invention relates to a method for producing chewing gum granules. The method comprises at least the steps of feeding a gum composition including at least gum base into an extruder (2), pressurizing the gum composition in the extruder, extruding the gum composition through a die plate (5), and cutting the extruded gum composition in a liquid filled chamber (4). The extruded gum composition comprises at least 71% Wt, gum base and the cut granules are included in compressed gum tablets. The invention further relates to a chewing gum product, and to a chewing gum granulating system.