Abstract: The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions. The 2-methyl substituted quinazoline compounds of general formula (I) effectively and selectively inhibit the Ras-Sos interaction without significantly targeting the EGFR receptor. They are therefore useful for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, such as cancer as a sole agent or in combination with other active ingredients.

Abstract: For the storing of paper rolls in high-shelf system stores and for the gunce of paper roll transporting cars, tracks disposed in pairs are provided which, for the accommodation of great weights, possess an approximately U-shaped cross-sectional configuration with a lower chord, an upper chord (180) and a web interconnecting both chords, which, proceeding devoid of any bends linearily and, with the aid of connections (183), is connected to a plurality of vertical supporting girders (184) disposed at a distance from each other and connected to the crossgirder (12) of the framework structure of the store, wherein the lower chord is formed by a leg (187) with a horizontally proceeding section forming the support for the paper roll transporting car and a section adjoining the latter which proceeds vertically and parallelly to the web, wherein the horizontal leg section is supported on and the vertical leg is supported against an angle section (188) connected to the vertical supporting girder (184) and the crossgir

Abstract: For the conveying and storing of paper rolls in a lying position in a high ay racking store and for removing them from the same, the high bay racking store (10) is provided with a plurality of shelf compartments disposed in rows above each other and in side-by-side arrangement, to which the individual paper rolls are supplied by means of relocation cars (50) and a paper roll trolley (70) mounted on the latter and traveling transversely to the longitudinal direction of the relocation car, in which the paper roll trolley (70) is moved with the paper roll in a raised position into the shelf compartment between paper roll supports (80) extending in the longitudinal direction of the shelf, the paper roll being subsequently deposited on said support.