Patents by Inventor Niels VAN DER VELDEN

Niels VAN DER VELDEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing an n-methylated (poly) peptide
    Patent number: 11180738
    Abstract: The present invention is directed to all aspects of novel methyl transferase enzymes that methylate backbone amides of (poly)peptides. The present invention also relates to nucleic acids encoding these enzymes as well as corresponding vectors and host cells comprising these. Moreover, the present invention encompasses the use of said enzymes for modifying (poly)peptides as well as corresponding methods. Also, the present invention pertains to further novel enzymes for modifying (poly)peptides derived from the omphalotin gene cluster of O. olearius and the homologous gene clusters from D. bispora, L. edodes and F. mediterranea as well as related aspects.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: November 23, 2021
    Assignee: ETH ZURICH
    Inventors: Markus Aebi, Markus Kunzler, Jorn Piel, Michael Freeman, Niels Van Der Velden, Noemi Kalin
  • NOVEL MULTIPLY BACKBONE N-METHYL TRANSFERASES AND USES THEREOF
    Publication number: 20190112583
    Abstract: The present invention is directed to all aspects of novel methyl transferase enzymes that methylate backbone amides of (poly)peptides. The present invention also relates to nucleic acids encoding these enzymes as well as corresponding vectors and host cells comprising these. Moreover, the present invention encompasses the use of said enzymes for modifying (poly)peptides as well as corresponding methods. Also, the present invention pertains to further novel enzymes for modifying (poly)peptides derived from the omphalotin gene cluster of O. olearius and the homologous gene clusters from D. bispora, L. edodes and F. mediterranea as well as related aspects.
    Type: Application
    Filed: April 7, 2017
    Publication date: April 18, 2019
    Inventors: Markus AEBI, Markus KUNZLER, Jorn PIEL, Michael FREEMAN, Niels VAN DER VELDEN, Noemi KALIN