Patents by Inventor Niels Witzke

Niels Witzke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Water-soluble guanidine derivatives of polyene macrolides and the esters thereof, and process for preparation thereof
    Patent number: 4396610
    Abstract: New guanidine derivatives of polyene macrolides having at least one free amino group and at least one free carboxy group (e.g. nystatin, pimaricin, amphotericin B, candicidin and trichomycin) are prepared by reacting the macrolide with a carbodiimide of the formula:R.sup.1 --N.dbd.C.dbd.N--R.sup.2wherein R.sup.1 and R.sup.2 are independently alkyl, substituted alkyl, cycloalkyl, aralkyl, aryl or aroylalkyl. Esters and salts of the derivatives can also be formed. The new derivatives are water-soluble and can be used as anti-mycotic agents.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: August 2, 1983
    Assignee: A/S Dumex (Dumex Ltd.)
    Inventor: Niels Witzke