Patents by Inventor Nigam M. Mishra

Nigam M. Mishra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITION OF NGLY1 FOR THE TREATMENT OF CANCER
    Publication number: 20240016828
    Abstract: In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.
    Type: Application
    Filed: August 23, 2023
    Publication date: January 18, 2024
    Applicant: University of North Texas Health Science Center
    Inventors: Yu-Chieh WANG, Victor J.T. LIN, Ashwini Ashwini ZOLEKAR, Kyle A. EMMITTE, Nigam M. MISHRA, Jin LIU
  • Inhibition of NGLY1 for the treatment of cancer
    Patent number: 11779592
    Abstract: In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula (I): wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: October 10, 2023
    Assignee: UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER
    Inventors: Yu-Chieh Wang, Victor J. T. Lin, Ashwini Zolekar, Kyle A. Emmitte, Nigam M. Mishra, Jin Liu
  • INHIBITION OF NGLY1 FOR THE TREATMENT OF CANCER
    Publication number: 20210205349
    Abstract: In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula (I): wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.
    Type: Application
    Filed: August 14, 2018
    Publication date: July 8, 2021
    Applicant: University of North Texas Health Science Center
    Inventors: Yu-Chieh Wang, Victor J.T. Lin, Ashwini Zolekar, Kyle A. Emmitte, Nigam M. Mishra, Jin Liu