Patents by Inventor Nigel Coates

Nigel Coates has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 18,21-Didesoxymacbecin Derivatives for the Treatment of Cancer
    Publication number: 20110160175
    Abstract: The present invention relates to macbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds involving incorporation of non-natural starter units and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: November 9, 2007
    Publication date: June 30, 2011
    Inventors: Christine Martin, Ming Zhang, Nigel Coates, William Vousden, Steven Moss, Sabine Gaisser
  • 4,5-Dihydromacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies
    Publication number: 20110091452
    Abstract: The present invention relates to 4,5-dihydromacbecin analogues to the formula (IA) or (IB), or a pharmaceutically acceptable salt there of: wherein: R1 represents H or CONH2 that are useful, e.g. in the treatment of cancer, B-cell malignancies malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: March 30, 2007
    Publication date: April 21, 2011
    Inventors: Christine Martin, Ming Zhang, Sabine Gaisser, Nigel Coates, Barrie Wilkinson
  • 17-Oxymacbecin Derivatives and Their Use in the Treatment of Cancer and/or B-Cell Malignancies
    Publication number: 20100068203
    Abstract: The present invention relates to 17-oxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: May 9, 2007
    Publication date: March 18, 2010
    Inventors: Christine Martin, Ming Zhang, Sabine Gaisser, Nigel Coates
  • Novel Compounds and Methods for Their Production
    Publication number: 20090298804
    Abstract: The present invention relates to 15-desmethoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: March 30, 2007
    Publication date: December 3, 2009
    Inventors: Sabine Gaisser, Christine Martin, Ming Zhang, Barrie Wilkinson, Nigel Coates, Mohammed Nur-E-Alam, Nikolaos Galtatzis
  • 18 ,21-Didesoxymacbecin Derivatives for the Treatment of Cancer
    Publication number: 20090253667
    Abstract: The present invention relates to 18,21-didesoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: May 9, 2007
    Publication date: October 8, 2009
    Inventors: Christine Martin, Ming Zhang, Nigel Coates, William Vousden, Steven Moss, Sabine Gaisser
  • 15-O-Desmethylmacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies
    Publication number: 20090209507
    Abstract: The present invention relates to 15-O-desmethylmacbecin analogues according to the formula (IA) or (IB) herein, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 either both represent H or together they represent a bond (i.e. C4 to C5 is a double bond); and R3 represents H or CONH2 that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: March 30, 2007
    Publication date: August 20, 2009
    Inventors: Sabine Gaisser, Christine Martin, Ming Zhang, Barrie Wilkinson, Nigel Coates, Mohammed Nur-E-Alam, William Vousden
  • Novel Compounds and Methods for Their Production
    Publication number: 20090117127
    Abstract: The present invention relates to 11-O-desmethylmacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: March 30, 2007
    Publication date: May 7, 2009
    Inventors: Sabine Gaisser, Christine Martin, Ming Zhang, Barrie Wilkinson, Lesley Sheehan, Nigel Coates, Mohammed Nur-E-Alam, William Vousden, Nikolaos Gaitatzis