Patents by Inventor Nigel Cooke

Nigel Cooke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combinations of JAK Inhibitors
    Publication number: 20130338168
    Abstract: The invention provides a pharmaceutical combination comprising: a) at least one agent selected from Bcr-Abl, Flt-3, FAK and RAF kinase inhibitors; and b) at least one JAK kinase inhibitor and a method for treating or preventing a proliferative disease using such a combination.
    Type: Application
    Filed: June 12, 2013
    Publication date: December 19, 2013
    Applicant: Novartis AG
    Inventors: Nigel Cooke, Paul Maniey
  • Indolylmaleimide derivatives
    Publication number: 20070191401
    Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.
    Type: Application
    Filed: February 20, 2007
    Publication date: August 16, 2007
    Inventors: Rainer Albert, Nigel Cooke, Sylvain Cottens, Claus Ehrhardt, Jean-Pierre Evenou, Richard Sedrani, Peter Von Matt, Jurgen Wagner, Gerhard Zenke
  • Indolylmaleimide derivatives
    Publication number: 20070184061
    Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.
    Type: Application
    Filed: February 20, 2007
    Publication date: August 9, 2007
    Inventors: Rainer Albert, Nigel Cooke, Sylvain Cottens, Claus Ehrhardt, Jean-Pierre Evenou, Richard Sedrani, Peter Von Matt, Jurgen Wagner, Gerhard Zenke
  • Indolylmaleimide derivatives
    Publication number: 20070155817
    Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.
    Type: Application
    Filed: February 20, 2007
    Publication date: July 5, 2007
    Inventors: Rainer Albert, Nigel Cooke, Sylvain Cottens, Claus Ehrhardt, Jean-Pierre Evenou, Richard Sedrani, Peter Von Matt, Jurgen Wagner, Gerhard Zenke
  • 2,4 Di (hetero) -arylamino-pyrimidine derivatives as ZAP-70 and/or syk inhibitors
    Publication number: 20060247262
    Abstract: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
    Type: Application
    Filed: March 16, 2006
    Publication date: November 2, 2006
    Inventors: Rolf Baenteli, Marie Bernhard, Peter Buehlmayer, Nigel Cooke, Rudolf Duthaler, Klaus Hinterding, Gebhard Thoma, Maurice Van Eis, Anette Von Matt, Louis Walliser, Gerhard Zenke
  • Pyrimidine derivaties
    Publication number: 20060100227
    Abstract: There are provided compounds of formula I Wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
    Type: Application
    Filed: March 14, 2003
    Publication date: May 11, 2006
    Inventors: Rolf Baenteli, Gerhard Zenke, Nigel Cooke, Rudolf Duthaler, Gebhard Thoma, Anette Von Matt, Toshiyuki Honda, Naoko Matsuura, Kazuhiko Nonomura, Osamu Ohmori, Ichiro Umemura, Klaus Hinterding, Christos Papageorgiou
  • Piperidine derivatives as ccr5 inhibitors
    Publication number: 20060004047
    Abstract: Disclosed are compounds of formula I: wherein R1, R2, R3 and X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disorders mediated by interactions between chemokine receptors and their ligands.
    Type: Application
    Filed: October 6, 2003
    Publication date: January 5, 2006
    Inventors: Rainer Albert, Nigel Cooke, Gebhard Thoma, Christian Bruns, Francois Nuninger, Markus Streiff, Hans-Gunter Zerwes