Patents by Inventor Nigel Fraser

Nigel Fraser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • miRNA of HSV-LAT and uses thereof
    Publication number: 20080069827
    Abstract: This invention relates to treatment of Herpes Symplex Virus infection. Specifically, the invention relates to the use of a newly discovered miRNA in the silencing of HSV-LAT gene, which is responsible for the prevention of apoptosis of infected neuronal cells and the maintenance of latency.
    Type: Application
    Filed: August 9, 2007
    Publication date: March 20, 2008
    Inventors: Nigel Fraser, Ananya Gupta
  • TREATMENT OF NON-NEURONAL CANCER USING HSV-1 VARIANTS
    Publication number: 20070292394
    Abstract: A mutant herpes simplex virus which has been modified in the ?34.5 gene such that the gene is non-functional is used to treat a non-neuronal cancer such as a mesothelioma, ovarian carcinoma, bladder cancer or melanoma. Typically, the mutant herpes simplex virus has been modified within the BamHI restriction fragment of the long terminal repeat of the viral genome.
    Type: Application
    Filed: June 19, 2007
    Publication date: December 20, 2007
    Inventors: Susanne Brown, Alasdair Maclean, Nigel Fraser, Bruce Randazzo, Steven Albelda, Larry Kaiser, John Kucharczuk
  • Treatment of cancer using HSV mutant
    Publication number: 20050260169
    Abstract: Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the ?34.5 gene in the long repeat region (RL) such that the ?34.5 gene is a non-functional, manufacture of medicaments and methods of testing cancer in mammals employing HSV mutant.
    Type: Application
    Filed: June 13, 2005
    Publication date: November 24, 2005
    Inventors: Alasdair MacLean, Susanne Brown, Nigel Fraser, Bruce Randazzo
  • Treatment of non-neuronal cancer using HSV-1 variants
    Publication number: 20050226850
    Abstract: A mutant herpes simplex virus which has been modified in the ?34.5 gene such that the gene is non-functional is used to treat a non-neuronal cancer such as a mesothelioma, ovarian carcinoma, bladder cancer or melanoma. Typically, the mutant herpes simplex virus has been modified within the BamHI restriction fragment of the long terminal repeat of the viral genome.
    Type: Application
    Filed: June 8, 2005
    Publication date: October 13, 2005
    Inventors: Susanne Brown, Alasdair MacLean, Nigel Fraser, Bruce Randazzo, Steven Albelda, Larry Kaiser, John Kucharczuk
  • Compounds and methods for treating and screening viral reactivation
    Publication number: 20050197307
    Abstract: This invention relates to host cellular factors as therapeutic and diagnostic compounds, and methods using such factors for screening for antiviral compounds, particularly compounds useful to treat Herpes virus infections, such as HSV-1 and HSV-2 infections.
    Type: Application
    Filed: December 17, 2004
    Publication date: September 8, 2005
    Inventors: Shelly Berger, Nigel Fraser, Jeffrey Leary, Ruth Tal-Singer
  • Method and apparatus for demonstrating mathematical relationships
    Publication number: 20030006986
    Abstract: A hand held computer device for teaching mathematical inter-relationships The device interactively and directly demonstrates the inter-relationship between a graphical representation of a mathematical relation and other representations of the mathematical relation such as an equation or table of values as a user manipulates a graph of the mathematical relation via a stylus/touch screen graphical user interface of the device. Such manipulation simultaneously correspondingly amends another displayed form of the mathematical relation.
    Type: Application
    Filed: April 10, 2001
    Publication date: January 9, 2003
    Inventors: Thomas P Dick, Nigel Fraser Hooke, Mark Howell, Charles M. Patton, Gregory Thorne Springer, Carla Randall
  • Synthesis of fluorinated ethers
    Patent number: 6225511
    Abstract: Fluorinated ethers of the formula: wherein R is hydrogen, fluorine, alkyl of 1 to 6 carbon atoms, or fluoroalkyl of 1 to 6 carbon atoms, R′ is hydrogen, alkyl of 1 to 6 carbon atoms, or fluoroalkyl of 1 to 6 carbon atoms, and R″ is fluorine, alkyl of 1 to 6 carbon atoms or fluoroalkyl of 1 to 6 carbon atoms are prepared by fluorinating a corresponding ether of formula: with a solid transition metal fluoride fluorinating agent such as cobaltic fluoride.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: May 1, 2001
    Assignee: Rhone-Poulenc Chemicals Ltd.
    Inventors: Owen Ross Chambers, Roderic Nigel Fraser Simpson
  • Synthesis of fluorinated ethers
    Patent number: 6054626
    Abstract: Fluorinated ethers of the formula: ##STR1## wherein R is hydrogen, fluorine, alkyl of 1 to 6 carbon atoms, or fluoroalkyl of 1 to 6 carbon atoms, R' is hydrogen, alkyl of 1 to 6 carbon atoms, or fluoroalkyl of 1 to 6 carbon atoms, and R" is fluorine, alkyl of 1 to 6 carbon atoms or fluoroalkyl of 1 to 6 carbon atoms, e.g. Desflurane, are prepared by fluorinating a corresponding ether of formula: ##STR2## with a solid transition metal fluoride fluorinating agent such as cobaltic fluoride.
    Type: Grant
    Filed: November 10, 1993
    Date of Patent: April 25, 2000
    Assignee: Rhodia Limited
    Inventors: Owen Ross Chambers, Roderic Nigel Fraser Simpson