Patents by Inventor Nigel Graham Cooke

Nigel Graham Cooke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4-diaminopyrimidine derivatives
    Patent number: 7943627
    Abstract: There are provided compounds of formula I wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: May 17, 2011
    Assignee: Novartis AG
    Inventors: Rolf Baenteli, Gerhard Zenke, Nigel Graham Cooke, Rudolf Duthaler, Gebhard Thoma, Anette Von Matt, Toshiyuki Honda, Naoko Matsuura, Kazuhiko Nonomura, Osamu Ohmori, Ichiro Umemura, Klaus Hinterding, Christos Papageorgiou
  • COMBINATIONS OF JAK INHIBITORS
    Publication number: 20100280003
    Abstract: The invention provides a pharmaceutical combination comprising: a) at least one agent selected from Bcr-Abl, Flt-3, FAK and RAF kinase inhibitors; and b) at least one JAK kinase inhibitor and a method for treating or preventing a proliferative disease using such a combination.
    Type: Application
    Filed: July 12, 2010
    Publication date: November 4, 2010
    Inventors: Nigel Graham Cooke, Paul W. Manley
  • Phenyl-Oxetanyl-Derivatives
    Publication number: 20100261766
    Abstract: Novel organic compounds are described and claimed which may in particular be useful in the treatment of diseases being triggered by the (human) autoimmune system.
    Type: Application
    Filed: December 1, 2008
    Publication date: October 14, 2010
    Inventors: Rainer Albert, Nigel Graham Cooke, Frederic Zecri
  • Indolylmaleimide derivatives
    Patent number: 7786123
    Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: August 31, 2010
    Inventors: Rainer Albert, Nigel Graham Cooke, Sylvain Cottens, Claus Ehrhardt, Jean-Pierre Evenou, Richard Sedrani, Peter Von Matt, Jürgen Wagner, Gerhard Zenke
  • 2,4- Di(hetero)-arylamino-pyrimidine Derivatives as ZAP-70 and/or SYK inhibitors
    Publication number: 20100152182
    Abstract: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
    Type: Application
    Filed: January 13, 2010
    Publication date: June 17, 2010
    Inventors: Rolf Baenteli, Marie Claude Bernhard, Peter Buehlmayer, Nigel Graham Cooke, Rudolf Duthaler, Klaus Hinterding, Gebhard Thoma, Maurice Van Eis, Anette Von Matt, Louis Walliser, Gerhard Zenke
  • COUMARIN DERIVATIVES
    Publication number: 20100144729
    Abstract: A compound of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Application
    Filed: January 31, 2008
    Publication date: June 10, 2010
    Inventors: Rolf Baenteli, Nigel Graham Cooke, Frederic Zecri, Alexander Baxter Smith
  • POLYCYCLIC COMPOUNDS
    Publication number: 20100087491
    Abstract: The invention relates to novel diaryl oxadiazole compounds of Formula I: in which all the variables are as defined in the specification; to their preparation and to their use in the treatment of disorder or disease mediated by lymphocytes.
    Type: Application
    Filed: September 27, 2007
    Publication date: April 8, 2010
    Inventors: Rainer Albert, Nigel Graham Cooke, Ian Lewis, Sven Weiler, Frederic Zecri
  • 2,4 Di (hetero) -arylamino-pyrimidine derivatives as ZAP-70 and/or syk inhibitors
    Patent number: 7671063
    Abstract: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: March 2, 2010
    Assignee: Novartis AG
    Inventors: Rolf Baenteli, Marie Claude Bernhard, Peter Buehlmayer, Nigel Graham Cooke, Rudolf Duthaler, Klaus Hinterding, Gebhard Thoma, Maurice Van Eis, Anette Von Matt, Louis Walliser, Gerhard Zenke
  • Indolylmaleimide Derivatives
    Publication number: 20090318463
    Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.
    Type: Application
    Filed: July 7, 2009
    Publication date: December 24, 2009
    Inventors: Rainer Albert, Nigel Graham Cooke, Sylvain Cottens, Claus Enrhardt, Jean-Pierre Evenou, Richard Sedrani, Peter Von Matt, Jurgen Wagner, Gerhard Zenke
  • Chromen-2-One Derivatives
    Publication number: 20090318546
    Abstract: A compound of formula (I) wherein R1, R2, R3, R4, R5, and ring A are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Application
    Filed: April 10, 2007
    Publication date: December 24, 2009
    Applicant: NOVARTIS AG
    Inventors: Rolf Baenteli, Nigel Graham Cooke, Sven Weiler, Frederic Zecri
  • Organic Compounds
    Publication number: 20090156602
    Abstract: The invention provides a pharmaceutical combination comprising: a) at least one agent selected from Bcr-Abl, Flt-3, FAK and RAF kinase inhibitors; and b) at least one JAK kinase inhibitor and a method for treating or preventing a proliferative disease using such a combination.
    Type: Application
    Filed: November 22, 2005
    Publication date: June 18, 2009
    Inventors: Nigel Graham Cooke, Paul W. Manley
  • Piperdine Derivatives as CCR5 Inhibitors
    Publication number: 20080249111
    Abstract: Disclosed are compounds of formula I: wherein R1, R2, R3 and X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disorders mediated by interactions between chemokine receptors and their ligands.
    Type: Application
    Filed: May 2, 2008
    Publication date: October 9, 2008
    Inventors: Rainer ALBERT, Nigel Graham Cooke, Gebhard Thoma, Christian Bruns, Francois Nuninger, Markus Streiff, Hans-Gunter Zerwes
  • Treatment of Autoimmune Diseases
    Publication number: 20080200438
    Abstract: Methods of treating various autoimmune diseases, such as multiple sclerosis, peripheral neuritis, optical neuritis, amylotrophic lateral sclerosis, and uveitis utilizing specific amino alcohol derivatives are provided herein.
    Type: Application
    Filed: September 7, 2006
    Publication date: August 21, 2008
    Inventors: Rainer Albert, Nigel Graham Cooke, Barbara Nusslein-Hildesheim, Sven Weiler
  • Piperidine derivatives as CCR5 inhibitors
    Patent number: 7399771
    Abstract: Disclosed are compounds of formula I: wherein R1, R2, R3 and X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disorders mediated by interactions between chemokine receptors and their ligands.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: July 15, 2008
    Assignee: Novartis AG
    Inventors: Rainer Albert, Nigel Graham Cooke, Gebhard Thoma, Christian Bruns, François Nuninger, Markus Streiff, Hans-Günter Zerwes
  • Indolylmaleimide derivatives
    Patent number: 6645970
    Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: November 11, 2003
    Assignee: Novartis AG
    Inventors: Rainer Albert, Nigel Graham Cooke, Sylvain Cottens, Claus Ehrhardt, Jean-Pierre Evenou, Richard Sedrani, Peter Von Matt, Jürgen Wagner, Gerhard Zenke
  • Tolerance induction
    Publication number: 20030073737
    Abstract: Tautomycetin or a derivative thereof is used to induce tolerance, e.g. unresponsiveness to alloantigens, in a subject.
    Type: Application
    Filed: October 10, 2002
    Publication date: April 17, 2003
    Inventors: Nigel Graham Cooke, Christoph Heusser
  • Indolylmaleimide derivatives
    Publication number: 20030069424
    Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.
    Type: Application
    Filed: November 5, 2001
    Publication date: April 10, 2003
    Inventors: Rainer Albert, Nigel Graham Cooke, Sylvain Cottens, Claus Ehrhardt, Jean-Pierre Evenou, Richard Sedrani, Peter Von Matt, Jurgen Wagner, Gerhard Zenke
  • Alpha4beta1 and alpha4beta7 integrin inhibitors
    Publication number: 20020091142
    Abstract: Compounds of the formula I 1
    Type: Application
    Filed: March 9, 2001
    Publication date: July 11, 2002
    Inventors: Nigel Graham Cooke, Michael Lloyd Sabio