Abstract: The present invention is directed to the targeting of drugs, peptides, and proteins to the brain. Liposomes containing the compound to be delivered are coupled to antibody binding fragments which bind to receptors on the vascular endothelium of the blood-brain barrier. The targeted receptors include transferrin receptor, insulin receptor, IGF-I and IGF-II receptors, among others. Also provided are pharmaceutical compositions and methods for administering the drugs to a subject in need by means of the receptor-targeted immunoliposomes.

Abstract: An improved method of cholinomimetic therapy for cognitive impairments associated with aging and Alzheimer's disease comprising treating a patient with an effective amount of phenserine or a pharmaceutically acceptable salt and derivatives.

Abstract: Substituted carbamates of tricyclic compounds which have a cyclic sulfer atom, provide highly potent and selective cholinergic agonist and blocking activity are useful as pharmaceutical agents. Cholinergic disease are treated with these compounds such as glaucoma, Myasthenia Gravis, Alzheimer's disease. Methods for inhibiting esterases, acetylcholinesterase and butyrylcholinesterase are also provided.

Abstract: Tertiary butyl esters of anticancer drugs are provided which have the following formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of H, F, Cl, Br, and I and R.sub.2 can also be NH.sub.2 ;R.sub.3, R.sub.4, and R.sub.5 are the same or different and are selected from the group consisting of H, F, Cl, Br, I, and C.sub.1 -C.sub.3 alkyl; wherein alkyl may be substituted with F, Cl, Br, or I, with the proviso that at least two of R.sub.3, R.sub.4, and R.sub.5 are alkyl or substituted alkyl; andn=0-4.The compounds of the present invention can be used in treating cancer by significantly increasing the brain levels of the drugs of the invention and their active metabolites.