Patents by Inventor Nigel Hywel-Jones

Nigel Hywel-Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel antituberculosis compounds, Hirsutellones A, B, and C
    Publication number: 20060122252
    Abstract: Three new alkaloids, Hirsutellones A, B, and C, are produced in cultures of fungus such as Hirsutella nivea strain BCC 2594 and Trichoderma sp. strain BCC 7579. The Hirsutellones exhibited potent growth inhibitory activity against Mycobacterium tuberculosis (H37Ra strain) with an MIC value of 0.78 ?g/ml, while showing weak or no cytotoxicity to mammalian cells. Therefore, Hirsutellones and pharmaceutical compositions containing Hirsutellones may be useful for the treatment of tuberculosis. Also described herein are methods of isolating the Hirsutellones.
    Type: Application
    Filed: November 21, 2005
    Publication date: June 8, 2006
    Inventors: Masahiko Isaka, Nigel Hywel-Jones, Sayanh Somrithipol, Kanyawim Kirtikara, Prasit Palittapongarnpim, Yodhathai Thebtaranonth