Abstract: A data transfer instruction is provided which specifies register addressing information for identifying a target portion of the register storage. In response to the data transfer instruction, instruction decoding circuitry controls processing circuitry to perform a data transfer operation to transfer data to or from the target portion of the register storage. The register addressing information includes at least: a base register identifier identifying a base register of the register storage for storing a base value; and an immediate value specified in an encoding of the data transfer instruction, the immediate value representing a value to be added to the base value to provide an index value for selecting the target portion of the register storage. This can be useful to provide an instruction set architecture which supports code that is scalable to variable data structure sizes, and which supports loop unrolling.

Abstract: In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and/or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.

Abstract: A method of removing deposits in a direct injection spark ignition engine, the method including combusting in the engine a gasoline fuel composition having a quaternary ammonium salt additive wherein the quaternary ammonium salt additive includes the quaternised reaction product of a hydrocarbyl substituted succinic acid derived acylating agent and a compound able to react with said acylating agent and which includes a tertiary amine group; in which each molecule of the hydrocarbyl substituted succinic acid derived acylating agent includes on average at least 1.2 succinic acid moieties.

Abstract: A method of cleaning up internal diesel injector deposits in a severely fouled engine, the method including combusting in the engine a diesel fuel composition having (a) a quaternary ammonium salt additive; and (b) one or more further nitrogen-containing detergents; in which the quaternary ammonium salt additive includes the quaternised reaction product of a hydrocarbyl substituted succinic acid derived acylating agent and a compound able to react with said acylating agent and which includes a tertiary amine group; in which each molecule of the hydrocarbyl substituted succinic acid derived acylating agent includes on average at least 1.2 succinic acid moieties.

Abstract: This disclosure relates to systems, methods, and apparatuses for determining access models for applications. The access models can be determined using various techniques described herein. The access models can enable the applications to be onboarded into the enterprise system and, in some cases, can be utilized by an identity and access management (IdAM) system and/or identity and governance administration (IGA) system to facilitate ongoing identity management and access control functions for the applications in the enterprise system.

Abstract: Instruction decoder to decode processing instructions; one or more first registers; first processing circuitry to execute the decoded processing instructions in a first processing mode and configured to execute the decoded processing instructions using the one or more first registers; and control circuitry to execute the decoded processing instructions in a second processing mode using one or more second registers; the instruction decoder being configured to decode processing instructions selected from a first instruction set and a second instruction set in the second processing mode, in which one or both of the first and second instruction sets comprises at least one unique instruction set; the instruction decoder configured to decode one or more mode change instructions to change between the first and second processing mode; and the first processing circuitry configured to change the current processing mode between the first and second processing mode responding to executing mode change instruction.

Abstract: In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and/or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.

Abstract: Systems and methods are provided for agentless attestation. Agentless attestation can measure the integrity of customer servers without requiring an agent software program to be downloaded to each of the enterprise computer devices. In particular, the system can integrate several standalone components to measure the integrity of monitored devices. This also allows the data center to authenticate, verify, audit, and update any hardware change, including a Platform Certificate.

Abstract: An apparatus and a method are provided for performing a splice operation, the apparatus having a set of vector registers and one or more control registers. Processing circuitry is arranged to execute a sequence of instructions including a splice instruction that identifies at least a first vector register and at least one control register. The first vector register stores a first vector of data elements having a vector length, and the at least one control register stores control data identifying, independently of the vector length, one or more data elements occupying sequential data element positions within the first vector of data elements. The processing circuitry is responsive to execution of the splice instruction to extract from the first vector each data element identified by the control data in the at least one control register, and to output the extracted data elements within a result vector of data elements that also contains data elements from a second vector.

Abstract: N-(3-substituted thiazaheterocyclylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides, N-(3-substituted thiazaheterocyclylidene)-1H-pyrrolo[2,3-b]pyridine-4-carboxamides and N-(3-substituted thiazaheterocyclylidene)-1H-pyrrolo[3,2-b]pyridine-1-carboxamides wherein the ring designated Q or Q? is a five-, six-, or seven-membered heterocycle containing one sulfur and one nitrogen are disclosed. The compounds activate Yap and inhibit Lats kinases. They are therefore useful for treating hearing loss.

Abstract: A technique includes an operating system agent of a computer system monitoring a process to detect whether an integrity of the process has been compromised. The monitoring includes the operating system agent scanning a data structure. The process executes in a user space, and the data structure is part of an operating system kernel space. The technique includes a hardware controller of the computer system listening for a heartbeat that is generated by the operating system agent. The hardware controller takes a corrective action in response to at least one of the hardware controller detecting an interruption of the heartbeat, or the operating system agent communicating to the hardware controller a security alert for the process.

Abstract: Apparatuses, methods and programs are disclosed relating to the predication of multiple vectors in vector processing. An encoding of predicate information is disclosed which comprises an element size and an element count, wherein the predicate information comprises a multiplicity of consecutive identical predication indicators given by the element count, each predication indicator corresponding to the element size.

Abstract: A method of modelling system behaviour of a physical system, the method including, in one or more electronic processing devices obtaining quantified system data measured for the physical system, the quantified system data being at least partially indicative of the system behaviour for at least a time period, forming at least one population of model units, each model unit including model parameters and at least part of a model, the model parameters being at least partially based on the quantified system data, each model including one or more mathematical equations for modelling system behaviour, for each model unit calculating at least one solution trajectory for at least part of the at least one time period; determining a fitness value based at least in part on the at least one solution trajectory; and, selecting a combination of model units using the fitness values of each model unit, the combination of model units representing a collective model that models the system behaviour.

Abstract: The present invention relates to an isolated antibody, or antigen binding fragment thereof, which specifically binds to an extracellular domain of CD300f, wherein the antibody, or antigen binding fragment thereof, comprises a heavy chain variable region which comprises: (a) an amino acid sequence that is at least 70% identical to the amino acid sequence represented by SEQ ID NO: 1; and/or (b) a complementarity determining region 1 (CDR1) that comprises the amino acid sequence represented by SEQ ID NO: 2, a complementarity determining region 2 (CDR2) that comprises an amino acid sequence that is represented by SEQ ID NO: 3, and/or a complementarity determining region 3 (CDR3) that comprises an amino acid sequence that is represented by SEQ ID NO: 4, compositions comprising the antibody, antigen binding fragment thereof, and uses for therapy.

Abstract: In some examples, a bus device includes a device controller to perform input/output (I/O) virtualization to provide a virtualized instance of the bus device. The device controller establishes a channel between the virtualized instance of the bus device and a guest operating system (OS) of a virtual machine (VM). The device controller receives, from the VM, address information relating to a portion of a memory containing information associated with a kernel of the guest OS, and obtains, for integrity inspection, the information associated with the kernel from the memory based on the address information.

Abstract: Provided herein is technology relating to testing fluid specimens and particularly, but not exclusively, to apparatuses, devices, methods, systems, and kits for testing a fluid specimen, e.g. urine, saliva, or other body fluids, to detect specified chemical components in the specimen.

Abstract: An apparatus and a method are provided for performing a splice operation, the apparatus having a set of vector registers and one or more control registers. Processing circuitry is arranged to execute a sequence of instructions including a splice instruction that identifies at least a first vector register and at least one control register. The first vector register stores a first vector of data elements having a vector length, and the at least one control register stores control data identifying one or more data elements occupying sequential data element positions within the first vector of data elements.

Abstract: Methods and/or apparatus provide for obtaining intrinsics and extrinsics of a plurality of cameras arranged to capture a scene and based thereon, generate a voxel representation of the scene; obtaining extrinsics and intrinsics of a virtual camera; mapping the extrinsics and intrinsics of the virtual camera to at least one voxel surface defined in a data structure and to identify at least one camera pair suitable for obtaining depth data for that voxel surface based on the corresponding camera pair identifier; and receiving an input from the mapping unit, and in response obtaining images captured by the cameras in the at least one camera pair identified as being suitable for reconstructing the scene from the viewpoint of the virtual camera, and to generate an image of the scene from the viewpoint of the virtual camera based on the obtained images.

Abstract: In some examples, a system receives information from electronic devices comprising network devices and computing devices in a computing environment that are subject to attestations of interfaces of the network devices and the computing devices. For each interface of a given computing device being attested, the system verifies that the interface of the given computing device is connected to an interface of a corresponding network device that is being attested. For each interface of a given network device being attested, the system verifies that the interface of the given network device is connected to an interface of a corresponding computing device that is being attested or an interface of another network device that is being attested.