Patents by Inventor Nigel John Watkins

Nigel John Watkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FC-Interferon-Beta Fusion Proteins
    Publication number: 20140005361
    Abstract: Disclosed are Fc-interferon-beta (Fc-IFN-?) fusion proteins and nucleic acid molecules encoding them. The Fc-IFN-? fusion proteins include variants of the interferon-beta (IFN-?) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.
    Type: Application
    Filed: August 26, 2013
    Publication date: January 2, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Stephen D. Gillies, Nigel John Watkins, Matthew Paul Baker, Kin-Ming Lo, Steven C. Degon
  • Stabilization of Fc-interferon-beta fusion proteins
    Patent number: 8557232
    Abstract: Disclosed are Fc-interferon-beta (Fc-IFN-?) fusion proteins and nucleic acid molecules encoding them. The Fc-IFN-? fusion proteins include variants of the interferon-beta (IFN-?) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: October 15, 2013
    Assignee: Merck Patent GmbH
    Inventors: Stephen D. Gillies, Nigel John Watkins, Matthew Paul Baker, Kin-Ming Lo, Steven C. Degon
  • Fc-interferon-beta fusion proteins
    Patent number: 7670595
    Abstract: Disclosed are Fc-interferon-beta (Fc-IFN-?) fusion proteins and nucleic acid molecules encoding them. The Fc-IFN-? fusion proteins include variants of the interferon-beta (IFN-?) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: March 2, 2010
    Assignee: Merck Patent GmbH
    Inventors: Stephen D. Gillies, Nigel John Watkins, Matthew Paul Baker, Kin-Ming Lo
  • ASSEMBLY AND FOLDING OF FC-INTERFERON-BETA FUSION PROTEINS
    Publication number: 20090191154
    Abstract: Disclosed are Fc-interferon-beta (Fc-IFN-?) fusion proteins and nucleic acid molecules encoding them. The Fc-IFN-? fusion proteins include variants of the interferon-beta (IFN-?) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.
    Type: Application
    Filed: February 27, 2009
    Publication date: July 30, 2009
    Applicant: Merck Patent GmbH
    Inventors: Stephen D. Gillies, Nigel John Watkins, Matthew Paul Baker, Kin-Ming Lo, Steven C. Degon