Abstract: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides molecules having structural features characteristic of immunoregulatory signalling (IRS) molecules and which are expressed by cells of haematopoietic lineages such as, in particular, leukocytes. The molecules of the present invention find broad application inter alia as diagnostic markers for cells, targets for cell therapy and as validated drug targets in order to modulate the immune response and to treat, prevent and diagnose a range of diseases conditions including cancer, genetic disease, inflammatory conditions and conditions associated with aberrant haematopoietic cell function or activity. The present invention extends to binding partners of the instant molecules such as, for example, antibodies, ligands, adaptor and other signalling associated molecules, agonists and antagonists and to methods of screening for same.

Abstract: A system has a virtual overlay infrastructure mapped onto physical resources for processing, storage and network communications, the virtual infrastructure having virtual entities for processing, storage and network communications. Virtual infrastructures of different users share physical resources but are isolated. Each infrastructure has its own infrastructure controller to create and configure the infrastructure. It has a user accessible part (CFC) for configuration of that user's infrastructure, and a user inaccessible part (UFC) able to access the mapping and the physical resources. This increases user control to ease system administration, while maintaining security by limiting access to the mapping.

Abstract: An industrial sieving or screening machine has a resonator rod on the separator screen. The rod extends between two spaced ends and has a transducer located at one end to excite the rod over its length to assist with deblinding the screen. The rod may be spiral in shape or shaped with other smoothly blended complex curves such as an S-shape. A spiral rod resonator fixed to the top of the sieve screen may be used as a guide for material to be screened.

Abstract: Disclosed are Fc-interferon-beta (Fc-IFN-?) fusion proteins and nucleic acid molecules encoding them. The Fc-IFN-? fusion proteins include variants of the interferon-beta (IFN-?) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.

Abstract: Apparatus is provided, in or for a screen separator for sieving materials, for clamping one or more sieve screen frames 78 within the confines of a chassis 40 of the separator to prevent egress of material from the separator. The apparatus comprises a sheath 50 extending around and embracing the chassis 40 and one or more expandable elements 66 for urging the sheath 50 against the chassis 40 and the screen frame(s) 78 to impart uniform clamping pressure to the clamped elements. The sheath 50 is designed to provide ease of mounting and release.

Abstract: The present invention relates generally to a novel lectin and to derivatives, homologues, analogues, chemical equivalents and mimetics thereof and, more particularly, to a novel type I C-type lectin, herein referred to as “DCL-1”. In particular, the present invention relates to the use of DCL-1 in therapeutic, prophylactic and diagnostic applications.

Abstract: The present invention relates generally to a method of generating lymphocytes specific for particular antigens. More particularly, the present invention provides a method for generating antigen-reactive T- cells and even more particularly cytotoxic (CD8+) T-cells in 10 vitro specific for antigens such as peptide antigens. The method of the present invention enables in vitro T-cell priming for particular antigens such as antigens on cancer cells, pathogenic cells, viruses or cells infected with viruses. The present invention is useful in identifying particularly immunogenic antigens for immunotherapy. Furthermore, as a consequence, the present invention is useful in avoiding the need for expensive and time 15 consuming clinical trials.

Abstract: A rotor arrangement comprising a rotor-section and a circumferential moveable seal around the rotor-section, the arrangement being such that, for a given rotation rate, the rotor-section is subject to an associated radial growth and a corresponding related axial displacement, relative to the seal, wherein the rotor-section is provided with an axially-varying profile for off-setting said radial growth of the rotor-section, adjacent the circumferential seal, at said given rotation rate.

Abstract: The invention relates to an improved process for the fluoridation of sugar derivatives in which a controlled amount of water is present in the solvent.

Abstract: A low-overhead/power-saving processor synchronization mechanism, and applications thereof. In an embodiment, the present invention provides a processor having a load-linked register. The processor implements instructions related to the load-linked register. A first instruction, when executed by the processor, causes the processor to load a first value specified by the first instruction in a first register of a register file and to load a second value in the load-linked register. A second instruction, when executed by the processor, causes the processor to suspend execution of a stream of instructions associated with the load-linked register if the second value in the load-linked register is unaltered until the second value in the load-linked register is altered.

Abstract: An industrial sieving or screening machine has a resonator rod on the separator screen. The rod extends between two spaced ends and has a transducer located at one end to excite the rod over its length to assist with deblinding the screen. The rod may be spiral in shape or shaped with other smoothly blended complex curves such as an S-shape. A spiral rod resonator fixed to the top of the sieve screen may be used as a guide for material to be screened.

Abstract: The present invention provides a method for the preparation of radioisotopically-labelled imaging agent compositions. The method uses precursors which are bound to soluble polymers, so that the radiolabelling reaction is carried out in solution. Also described are radiopharmaceutical compositions, automated versions of the radiolabelling method and disposable cassettes for use in the automated method.

Abstract: A method of multi-domain authorization/authentication on a computer network comprises: a user making a request to a policy enforcement point of a computer for access to information on the computer; providing a location address for a user's authorization and/or authentication information, a policy decision point of the service on the computer network then verifying the authorization/authentication information; and the user being given access by the PEP to the information or the service requested, if the request is accepted, wherein the user's authorization/authentication and/or further information is located on a meta policy decision point (MPDP).

Abstract: A biosensor for determining the concentration of an analyte in a biological sample. The biosensor comprises a support, a reference electrode or a counter electrode or both disposed on the support, a working electrode disposed on the support, the working electrode spaced apart from the other electrode or electrodes on the support, a covering layer defining a sample chamber over the electrodes, an aperture in the covering layer for receiving a sample, and at least one layer of mesh in the sample chamber between the covering layer and the electrodes. The at least one layer of mesh has coated thereon a silicone surfactant. Certain silicone surfactants are as effective as fluorinated surfactants with respect to performance of biosensors. These surfactants, when coated onto the mesh layer of the biosensor, are effective in facilitating the transport of aqueous test samples, such as blood, in the sample chamber.

Abstract: An ink container 10 comprises a serial arrangement of three chambers 32, 34, 36. The ink container 10 defines an ink supply port 42, 56, 60 for each chamber 32, 34, 36. The ink supply port 60 of one chamber 32 is displaced from alignment with a porous member in the chamber 32.

Abstract: The invention describes a method for stripping alumina which is particularly suitable for removal of fluoride from alumina and comprises washing said alumina with an aqueous acid or alkali at elevated temperature. The method may be used for removal of unreacted radiofluoride such as [18F]fluoride from alumina following a radiofluorination reaction. Automated synthesis apparatus and cassettes therefor, which are adapted to perform the method are also claimed.

Abstract: The present invention relates to modified GTP cyclohydrolase II enzymes that display increased specific activity, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing riboflavin, a riboflavin precursor, FMN, FAD, or a derivative thereof.

Abstract: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides molecules having structural features characteristic of immunoregulatory signalling (IRS) molecules and which are expressed by cells of haematopoietic lineages such as, in particular, leukocytes. The molecules of the present invention find broad application inter alia as diagnostic markers for cells, targets for cell therapy and as validated drug targets in order to modulate the immune response and to treat, prevent and diagnose a range of diseases conditions including cancer, genetic disease, inflammatory conditions and conditions associated with aberrant haematopoietic cell function or activity. The present invention extends to binding partners of the instant molecules such as, for example, antibodies, ligands, adaptor and other signalling associated molecules, agonists and antagonists and to methods of screening for same.

Abstract: A display assembly and a method of making a display assembly are disclosed. A display assembly is disclosed including a display unit 1 and two transparent plates 2, 3 bonded respectively to the front and rear surfaces of the display unit 1 by an adhesive. A tape is secured along at least one side of at least one of the plates 2, 3 on its inner surface such that the adhesive inner region of the tape bonds with the tape and not directly with the surface of the plates 2, 3.

Abstract: A process for the preparation of a target fermentation product comprising cultivation of an aerobic microorganism to produce such product, wherein in the microorganism the efficiency of the respiratory chain is increased, transformed and novel nucleotide sequences.