Abstract: The present invention relates to methods of influencing the flux or surface retention time of a topically active pharmaceutical ingredient through skin and formulations relating thereto.

Abstract: An airfoil for a gas turbine engine includes: opposed pressure and suction sidewalls extending between spaced-apart leading and trailing edges, a root, and a tip; and a hollow plenum disposed between the sidewalls. The plenum has a chordwise first dimension at a radially outer end thereof, and a chordwise second dimension at a radially inner end thereof. The second dimension is substantially less than the first dimension.

Abstract: A method for generating an internal pack coating having different, controlled thicknesses includes partially filling a root opening of a turbine blade having a cavity therein with a first powder and a second powder having different formulations so that the first powder contacts a first predefined portion of the surface of the cavity and the second powder contacts a second predefined portion of the surface of the cavity. The method further includes heating the object with the first powder and the second powder therein to thereby produce a coating of the internal cavity having different coating thicknesses over the first portion of the surface of the cavity and the second portion of the surface of the cavity.

Abstract: An aluminide coating is produced on a hollow article by furnishing an article having a hollow interior and an access opening to the hollow interior, placing an aluminide coating tape into the hollow interior through the access opening, and vapor phase aluminiding the hollow article using an external aluminum vapor source in addition to the aluminide coating tape.