Patents by Inventor Nigel Mackman

Nigel Mackman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090022729
    Abstract: The present invention provides methods and pharmaceutical compositions for treating or preventing cardiac dysfunctions (e.g., cardiac hypertrophy, cardiac remodeling, or heart failure) in subjects who have or are likely to develop cardiomyopathies. Some of the methods are directed to therapeutic or prophylactic treatment of cardiac dysfunctions in subjects having undergone myocardial injuries such as cardiac ischemia/reperfusion or myocardial infarction. Typically, these methods comprising administering to the subjects a therapeutic composition comprising a compound which can specifically inhibit PAR1 mediated signaling or down-regulate the cellular level of PAR1.
    Type: Application
    Filed: April 11, 2008
    Publication date: January 22, 2009
    Inventors: Nigel Mackman, Rafal Pawlinski, Burns C. Blaxall
  • Patent number: 5143830
    Abstract: A process for the production of a polypeptide in which host cells transformed with DNA coding for a fusion protein comprising the polypeptide and a further peptide comprising a C-terminal secretion sequence are cultured to express and secrete the fusion protein. The C-terminal secretion sequence is, for example, the haemolysin C-terminal secretion sequence.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: September 1, 1992
    Inventors: Ian B. Holland, Nigel Mackman, Jean-Marc Nicaud