Patents by Inventor Nigel Patrick Groome

Nigel Patrick Groome has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody to inhibin/ activin ?-B subunit
    Patent number: 8383351
    Abstract: The present invention provides an improved antibody specific for the inhibin/activin beta-B subunit polypeptide. The antibody is highly specific for the beta-B subunit in a sample, and does not require processing of the sample with heat or oxidizing agents. Thus, discovery of the new antibody provides for simpler, more accurate immunoassays for a wider range of sample types.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: February 26, 2013
    Assignee: Oxford Brookes University
    Inventors: Nigel Patrick Groome, Helen Ludlow
  • Immunological assay and antibodies for anti-mullerian hormone
    Patent number: 7897350
    Abstract: The present invention discloses compositions and methods to measure an amount of Anti-Mullerian Hormone (AMH) in a sample, including a mammalian sample such as a primate, rodent, equine, or bovine sample. The compositions and methods herein also provide antibodies that bind to epitopes on AMH that are stable to proteolysis of AMH.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: March 1, 2011
    Assignees: Beckman Coulter, Inc., Oxford Brookes University
    Inventors: Nigel Patrick Groome, Mark Cranfield, Axel P. N. Themmen, Gopal V. Savjani, Ketusha Mehta
  • ANTIBODY TO INHIBIN/ ACTIVIN BETA-B SUBUNIT
    Publication number: 20090317921
    Abstract: The present invention provides an improved antibody specific for the inhibin/activin beta-B subunit polypeptide. The antibody is highly specific for the beta-B subunit in a sample, and does not require processing of the sample with heat or oxidizing agents. Thus, discovery of the new antibody provides for simpler, more accurate immunoassays for a wider range of sample types.
    Type: Application
    Filed: June 11, 2009
    Publication date: December 24, 2009
    Applicant: OXFORD BROOKES UNIVERSITY
    Inventors: Nigel Patrick Groome, Helen Ludlow
  • Diagnosis of pre-eclampsia
    Patent number: 6620590
    Abstract: A method for diagnosis of pre-eclampsia is disclosed, which comprises measuring the hormone inhibin A in a biological sample such as maternal serum. The method allows non-invasive, early diagnosis and can be used to predict the onset of secondary symptoms.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: September 16, 2003
    Assignees: Isis Innovation Limited, The University of Reading, Oxford Brookes University
    Inventors: Nigel Patrick Groome, Philip Gerald Knight, William Leigh Ledger, Christopher Willard George Redman, Shanthi Muttukrishna
  • Diagnosis of pre-eclampsia
    Publication number: 20010055781
    Abstract: A method for diagnosis of pre-eclampsia is disclosed, which comprises measuring the hormone inhibin A in a biological sample such as maternal serum. The method allows non-invasive, early diagnosis and can be used to predict the onset of secondary symptoms.
    Type: Application
    Filed: April 25, 2001
    Publication date: December 27, 2001
    Inventors: Nigel Patrick Groome, Philip Gerald Knight, William Leigh Ledger, Christopher Willard George Redman, Shanthi Muttukrishna
  • Method of genetic testing
    Patent number: 5952182
    Abstract: Elevated levels of Inhibin-A in maternal serum or plasma have been shown to indicate the presence of Down's Syndrome. The assay method comprises the use of a monoclonal antibody specific for at least part of the inhibin-A .beta. sub-unit (.beta.A), and another monoclonal antibody specific for at least part of the Inhibin-A .alpha. sub-unit. The .beta.A antibody is used to capture Inhibin-A from the test sample, and the .alpha. sub-unit antibody is used as the detection antibody and is linked to a detectable marker. The method is carried out in the first or second trimester as a screening test to select patients for subsequent diagnostic testing.
    Type: Grant
    Filed: February 11, 1997
    Date of Patent: September 14, 1999
    Assignee: Oxford Brookes University
    Inventors: Nigel Patrick Groome, Euan Morrison Wallace