Patents by Inventor Nigel Scrutton

Nigel Scrutton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi-Enzyme Nanoparticle-Assisted Stable Isotope Incorporation Into Small Molecules by Channeling
    Publication number: 20220307004
    Abstract: Multi-enzyme systems attached to nanoparticles are effective to efficiently and controllably incorporate stable isotopes (such as deuterium) during the synthesis of small molecules. In one example, deuterium is incorporated into (+)-dihydrocarvide using a cascade involving the enzymes (a) pentaerythritol tetranitrate reductase (PETNR) and (b) flavin-dependent cyclohexanone monooxygenase triple variant F249A/F280A/F435A (CHMO3M).
    Type: Application
    Filed: March 28, 2022
    Publication date: September 29, 2022
    Inventors: Igor L. Medintz, Joyce C. Breger, Gregory A. Ellis, Kirk Malone, Nigel Scrutton
  • CARBON COMPOUND PRODUCTION IN PHOTOSYNTHETIC MICROORGANISMS
    Publication number: 20220220512
    Abstract: A method of upregulating the synthesis of pyruvate and/or a metabolite of pyruvate in a photosynthetic microorganism, a method for the photosynthetic production of a one, two, three or four carbon compounds, and a method for the production of ethanol from a photosynthetic microorganism are disclosed.
    Type: Application
    Filed: June 10, 2020
    Publication date: July 14, 2022
    Inventors: Nigel SCRUTTON, Matthew FAULKNER, Helen TOOGOOD
  • LINALOOL SYNTHASES
    Publication number: 20220213510
    Abstract: Linalool synthase variants are disclosed. The variants preferably comprise an amino acid sequence having one or more amino acid substitutions. Variants producing a greater linalool yield and/or higher linalool:nerolidol ratio compared with the corresponding wild type linalool synthase are also disclosed. A method comprising the conversion of geranyl pyrophosphate to linalool using a linalool synthase variant is also disclosed.
    Type: Application
    Filed: May 19, 2020
    Publication date: July 7, 2022
    Inventors: Nigel SCRUTTON, Nicole LEFERINK
  • Hydrocarbon production
    Patent number: 11174474
    Abstract: A fatty acid decarboxylase is disclosed, the fatty acid decarboxylase comprising at least 40% sequence identity to SEQ ID NO:1 or 2, and an amino acid substitution at a position corresponding to G462 of SEQ ID NO:1.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: November 16, 2021
    Assignee: C3 BIOTECHNOLOGIES LIMITED
    Inventors: Nigel Scrutton, Helen Toogood, Robin Hoeven
  • HYDROCARBON PRODUCTION
    Publication number: 20210163915
    Abstract: A fatty acid decarboxylase is disclosed, the fatty acid decarboxylase comprising at least 40% sequence identity to SEQ ID NO:1 or 2, and an amino acid substitution at a position corresponding to G462 of SEQ ID NO:1.
    Type: Application
    Filed: April 17, 2019
    Publication date: June 3, 2021
    Inventors: Nigel SCRUTTON, Helen TOOGOOD, Robin HOEVEN
  • KYNURENINE 3-MONOOXYGENASE (KMO) INHIBITORS, AND USES AND COMPOSITIONS THEREOF
    Publication number: 20200345745
    Abstract: There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein: L, X, R1, R2 and n have meanings provided in the description, which compounds are useful in the treatment of neurodegenerative and neuroinflammatory diseases.
    Type: Application
    Filed: November 20, 2018
    Publication date: November 5, 2020
    Inventors: Nigel Scrutton, Flaviano Giorgini
  • Compositions and methods for recombinant biosynthesis of propane
    Patent number: 10822624
    Abstract: Provided are genetically engineered microorganism that catalyze the synthesis of propane and/or butanol from a suitable substrate such as glucose. Also provided are methods of engineering said genetically engineered microorganism and methods of producing propane and/or butanol using the genetically engineered microorganism.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: November 3, 2020
    Assignee: C3 BIO-TECHNOLOGIES LIMITED
    Inventors: Nigel Scrutton, Patrik Jones, Navya Menon
  • COMPOSTITIONS AND METHODS FOR RECOMBINANT BIOSYNTHESIS OF PROPANE
    Publication number: 20190323040
    Abstract: Provided are genetically engineered microorganism that catalyze the synthesis of propane and/or butanol from a suitable substrate such as glucose. Also provided are methods of engineering said genetically engineered microorganism and methods of producing propane and/or butanol using the genetically engineered microorganism.
    Type: Application
    Filed: May 7, 2019
    Publication date: October 24, 2019
    Inventors: Nigel Scrutton, Patrik Jones, Navya Menon
  • Compositions and methods for recombinant biosynthesis of propane
    Patent number: 10337032
    Abstract: Provided are genetically engineered microorganism that catalyze the synthesis of propane and/or butanol from a suitable substrate such as glucose. Also provided are methods of engineering said genetically engineered microorganism and methods of producing propane and/or butanol using the genetically engineered microorganism.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: July 2, 2019
    Assignee: THE UNIVERSITY OF MANCHESTER
    Inventors: Nigel Scrutton, Patrik Jones, Navya Menon
  • COMPOSTITIONS AND METHODS FOR RECOMBINANT BIOSYNTHESIS OF PROPANE
    Publication number: 20170218401
    Abstract: Provided are genetically engineered microorganism that catalyze the synthesis of propane and/or butanol from a suitable substrate such as glucose. Also provided are methods of engineering said genetically engineered microorganism and methods of producing propane and/or butanol using the genetically engineered microorganism.
    Type: Application
    Filed: February 1, 2017
    Publication date: August 3, 2017
    Inventors: Nigel Scrutton, Patrik Jones, Navya Menon