Patents by Inventor Nigel Sharfe

Nigel Sharfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for modulating cell proliferation
    Patent number: 7598419
    Abstract: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: October 6, 2009
    Assignee: HSC Research and Development Limited Partnership
    Inventors: Chaim M. Roifman, Peter Demin, Andrew Freywald, Thomas Grunberger, Olga Rounova, Nigel Sharfe
  • Ephrin and EPH receptor mediated immune modulation
    Publication number: 20070292904
    Abstract: Methods and compositions for immune modulation are described. The methods involve modulating an ephrin or Eph receptor which consequently modulates an immune response, in particular a T cell response, modulates immune adhesion cell, modulates chemotaxis and/or migration or modulates apoptosis. The method is useful in treating a variety of conditions, including autoimmune disease, allergy, graft versus host disease, transplant rejection and cancer.
    Type: Application
    Filed: February 8, 2007
    Publication date: December 20, 2007
    Applicant: The Hospital for Sick Children
    Inventors: Chaim Roifman, Andrew Freywald, Nigel Sharfe, Thomas Grunberger, Eyal Grunebaum
  • Novel Compounds for Modulating Cell Proliferation
    Publication number: 20070243612
    Abstract: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.
    Type: Application
    Filed: March 22, 2005
    Publication date: October 18, 2007
    Applicant: HSC Research and Development Limited Partnership
    Inventors: Chaim Roifman, Peter Demin, Andrew Freywald, Thomas Grunberger, Olga Rounova, Nigel Sharfe
  • Methods of modulation of the immune system
    Publication number: 20070218070
    Abstract: Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signalling, T cell proliferation, and induction of T cell death. Methods of modulating EphB6 are described as well as various therapeutic applications.
    Type: Application
    Filed: March 2, 2007
    Publication date: September 20, 2007
    Applicant: The Hospital For Sick Children
    Inventors: Chaim Roifman, Andrew Freywald, Nigel Sharfe, Thomas Grunberger, Eyal Grunebaum
  • Methods of modulation of the immune system
    Patent number: 7205113
    Abstract: Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signaling, T cell proliferation, and induction of T cell death. Methods of modulating EphB6 are described as well as various therapeutic applications.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: April 17, 2007
    Assignee: The Hospital for Sick Children
    Inventors: Chaim M. Roifman, Andrew Freywald, Nigel Sharfe, Thomas Grunberger, Eyal Gruebaum
  • Compounds for modulating cell proliferation
    Patent number: 7012095
    Abstract: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of Formula (I).
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: March 14, 2006
    Assignee: HSC Research and Development Limited
    Inventors: Chaim M. Roifman, Thomas Grunberger, Olga Rounova, Demin Peter, Nigel Sharfe
  • Styryl acrylonitrile compounds and their use to promote myelopoiesis
    Publication number: 20050014690
    Abstract: The invention relates to the use of organic compounds, styryl acrylonitrile compounds to promote myelopoiesis. These compounds thefore may be used to treat a subject suffering from neutropenia and other conditions which would benefit from increased myelopoieses. Moreover, the compounds may be used to treat hematopoietic cells ex-vivo to promote myelopoiesis and therefore may be used advantageously in bone marrow or peripheral blood stem cell transplant.
    Type: Application
    Filed: October 11, 2002
    Publication date: January 20, 2005
    Inventors: Chaim Roifman, Thomas Grunberger, Nigel Sharfe, Olga Rounova, Demin Peter, Andrew Freywald
  • Ephrin and eph receptor mediated immune modulation
    Publication number: 20040247592
    Abstract: Methods and compositions for immune modulation are described. The methods involve modulating an ephrin or Eph receptor which consequently modulates an immune response, in particular a T cell response, modulates immune adhesion cell, modulates chemotaxis and/or migration and modulates apoptosis. The method is useful in treating a variety of conditions, including autoimmune disease, allergy, graft versus host disease, transplant rejection and cancer.
    Type: Application
    Filed: June 29, 2004
    Publication date: December 9, 2004
    Inventors: Chaim M. Roifman, Andrew Freywald, Nigel Sharfe, Thomas Grunberger, Eyal Grunebaum
  • Novel compounds for modulating cell proliferation
    Publication number: 20040209845
    Abstract: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.
    Type: Application
    Filed: March 17, 2004
    Publication date: October 21, 2004
    Applicant: HSC Research and Development Limited Partnership
    Inventors: Chaim M. Roifman, Thomas Grunberger, Olga Rounova, Demin Peter, Nigel Sharfe
  • Compounds for modulating cell proliferation
    Patent number: 6800659
    Abstract: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: October 5, 2004
    Assignee: HSC Research and Development Limited Partnership
    Inventors: Chaim M. Roifman, Thomas Grunberger, Olga Rounova, Demin Peter, Nigel Sharfe
  • Novel compounds for modulating cell proliferation
    Publication number: 20040072803
    Abstract: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of Formula (1).
    Type: Application
    Filed: October 27, 2003
    Publication date: April 15, 2004
    Inventors: Chaim M. Roifman, Thomas Grunberger, Olga Rounova, Demin Peter, Nigel Sharfe
  • Methods of modulation of the immune system
    Publication number: 20030113328
    Abstract: Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signalling, T cell proliferation, and induction of T cell death. Methods of modulating EphB6 are described as well as various therapeutic applications.
    Type: Application
    Filed: October 26, 2002
    Publication date: June 19, 2003
    Inventors: Chaim M Roifman, Andrew Freywald, Nigel Sharfe, Thomas Grunberger, Eyal Gruebaum
  • Novel compounds for modulating cell proliferation
    Publication number: 20030109502
    Abstract: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.
    Type: Application
    Filed: April 12, 2001
    Publication date: June 12, 2003
    Inventors: Chaim M. Roifman, Thomas Grunberger, Olga Rounova, Demin Peter, Nigel Sharfe