Patents by Inventor Nigel W. Fraser

Nigel W. Fraser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of Non-Neuronal Cancer using HSV-1 Variants
    Publication number: 20110195053
    Abstract: A mutant herpes simplex virus which has been modified in the ?34.5 gene such that the gene is non-functional is used to treat a non-neuronal cancer such as a mesothelioma, ovarian carcinoma, bladder cancer or melanoma. Typically, the mutant herpes simplex virus has been modified within the BamHI restriction fragment of the long terminal repeat of the viral genome.
    Type: Application
    Filed: April 20, 2011
    Publication date: August 11, 2011
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CRUSADE LABORATORIES LIMITED, WISTAR INSTITUTE
    Inventors: Susanne M. Brown, Alasdair R. Maclean, Nigel W. Fraser, Bruce P. Randazzo, Steven Albelda, Larry Kaiser, John Kucharczuk
  • Method of delivering genes to the central nervous system of a mammal
    Patent number: 7402308
    Abstract: The invention provides a method of delivering a selected DNA sequence to the central nervous system of a mammal by administering to said mammal a neurotropic virus, said virus containing a selected DNA sequence under the control of a promoter which permits expression of the DNA during the latent infectious state of the virus.
    Type: Grant
    Filed: February 23, 1995
    Date of Patent: July 22, 2008
    Assignees: Trustees of the University of Pennsylvania, The Wistar Institute
    Inventors: John H. Wolfe, Nigel W. Fraser
  • Method and compositions for stabilizing unstable gene transcripts
    Patent number: 6159710
    Abstract: A polynucleotide molecule useful for stably producing a gene product includes a polynucleotide sequence encoding the gene product (or alternatively a gene transcript) flanked by a 5' sequence and a 3' of an intron. Methods and compositions using this molecule permit enhanced recombinant expression of the gene product and are particularly useful in stabilizing unstable mRNA transcripts, permitting the stable production of desirable genes encoded thereby. Vectors and host cells containing this molecule are useful in the methods.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: December 12, 2000
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Nigel W. Fraser, Janice M. Zabolotny, Claude F. Krummenacher