Patents by Inventor Nihal Tugcu

Nihal Tugcu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-affinity, low molecular-mass displacers for ion-exchange chromotography
    Patent number: 7189324
    Abstract: A method for separating one or more components of a biomolecule mixture by means of an ion exchange chromatographic system operated in the displacement mode includes sequentially perfusing the system with a first solution including the biomolecule mixture, and a second solution including a displacer having a structure selected from formula I and formula II:
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: March 13, 2007
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Steven M. Cramer, James A. Moore, Sun Kyu Park, Nihal Tugcu
  • High-affinity, low-molecular-mass displacers for ion-exchange chromatography
    Patent number: 6929747
    Abstract: A method for separating one or more components of a biomolecule mixture by means of an ion exchange chromatographic system operated in the displacement mode includes sequentially perfusing the system with a first solution including the biomolecule mixture, and a second solution including a displacer having a structure selected from formula I and formula II:
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: August 16, 2005
    Assignee: Renesselaer Polytechnic Institute
    Inventors: Steven M. Cramer, James A. Moore, Sun Kyu Park, Nihal Tugcu
  • High throughput screening of potential displacer molecules
    Publication number: 20050176937
    Abstract: A bioproduct may be selectively separated from one or more impurities by means of a displacement chromatography system that includes a solvent, a chromatographic resin and a chemically selective displacer. The method includes: dissolving the bioproduct and the one or more impurities in a solvent; loading the bioproduct and the one or more impurities, in the solvent, on a chromatographic resin; displacing the bioproduct from the chromatographic resin with chemically selective displacer; and retaining the one or more impurities on the chromatographic resin. For this method, the bioproduct and the impurities have similar binding affinity for the chromatographic resin in the absence of the displacer.
    Type: Application
    Filed: April 11, 2005
    Publication date: August 11, 2005
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Steven Cramer, Kaushal Rege, Jonathan Dordick, Nihal Tugcu
  • High-affinity, low-molecular-mass displacers for ion-exchange chromatography
    Publication number: 20030232973
    Abstract: A method for separating one or more components of a biomolecule mixture by means of an ion exchange chromatographic system operated in the displacement mode includes sequentially perfusing the system with a first solution including the biomolecule mixture, and a second solution including a displacer having a structure selected from formula I and formula II: 1
    Type: Application
    Filed: February 28, 2003
    Publication date: December 18, 2003
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Steven M. Cramer, James A. Moore, Sun Kyu Park, Nihal Tugcu