Patents by Inventor Niketa Patel

Niketa Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PKC-Delta-I inhibitor formulations and uses thereof
    Patent number: 11844779
    Abstract: Provided herein are formulations that can contain an effective amount of a PKC? inhibitor. Also provided herein are methods of inhibiting a PKC? in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKC?.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: December 19, 2023
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Niketa A. Patel, Rekha S. Patel, Robert Pleasants Sparks, Wayne Charles Guida
  • Human Adipose-Derived Stem Cell Exosomes And Their Packaging For Use At Room Temperature
    Publication number: 20230398155
    Abstract: Disclosed are compositions comprising adipose stem cell (ASC) derived exosomes. Disclosed are lyophilized compositions comprising adipose stem cell (ASC) derived exosomes. Disclosed are methods of treating a wound comprising administering a composition comprising one or more adipose stem cell derived exosomes to a wound of a subject. Disclosed are methods of promoting wound healing comprising administering a composition comprising one or more adipose stem cell derived exosomes to a wound of a subject. Disclosed are methods of accelerating wound closure time comprising administering a composition comprising one or more adipose stem cell derived exosomes to a wound of a subject. Disclosed are methods of reducing oxidative stress in a human dermal fibroblasts (HDF) comprising contacting an HDF with a composition comprising one or more adipose stem cell derived exosomes.
    Type: Application
    Filed: April 14, 2023
    Publication date: December 14, 2023
    Inventor: NIKETA A. PATEL
  • METHODS AND COMPOSITIONS FOR DIAGNOSIS AND MANAGEMENT OF NEURODEGERATIVE DISEASES
    Publication number: 20220195524
    Abstract: Described herein are assays, methods, and devices for diagnosing/prognosing Alzheimer's disease (AD) and/or a neurodegenerative disease in a subject. The assays, methods, and/or devices described herein can be configured to detect GAS5 long-coding RNAs and/or expression thereof in a sample from a subject.
    Type: Application
    Filed: January 4, 2022
    Publication date: June 23, 2022
    Inventors: Niketa A. Patel, Jianfeng Cai
  • GAS5 binding compounds, formulations, and uses thereof
    Patent number: 11278521
    Abstract: Provided herein are compounds that can bind GAS5 long non-coding RNA, compositions thereof, and uses thereof.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 22, 2022
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS OFFICE OF GENERAL COUNSEL—PSG IV (024)
    Inventors: Niketa A. Patel, Jianfeng Cai
  • Methods and compositions for diagnosis and management of neurodegerative diseases
    Patent number: 11214835
    Abstract: Described herein are assays, methods, and devices for diagnosing/prognosing Alzheimer's disease (AD) and/or a neurodegenerative disease in a subject. The assays, methods, and/or devices described herein can be configured to detect GAS5 long-coding RNAs and/or expression thereof in a sample from a subject.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: January 4, 2022
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Niketa A. Patel, Jianfeng Cai
  • PKC-DELTA-I INHIBITOR FORMULATIONS AND USES THEREOF
    Publication number: 20210401802
    Abstract: Provided herein are formulations that can contain an effective amount of a PKC? inhibitor. Also provided herein are methods of inhibiting a PKC? in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKC?.
    Type: Application
    Filed: September 13, 2021
    Publication date: December 30, 2021
    Inventors: NIKETA A. PATEL, REKHA S. PATEL, ROBERT PLEASANTS SPARKS, WAYNE CHARLES GUIDA
  • PKC-delta-I inhibitor formulations and uses thereof
    Patent number: 11129808
    Abstract: Provided herein are formulations that can contain an effective amount of a PKC? inhibitor. Also provided herein are methods of inhibiting a PKC? in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKC?.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: September 28, 2021
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERRANS AFFAIRS OFFICE OF THE GENERAL COUNSEL
    Inventors: Niketa A. Patel, Rekha S. Patel, Robert Pleasants Sparks, Wayne Charles Guida
  • GAS5 BINDING COMPOUNDS, FORMULATIONS, AND USES THEREOF
    Publication number: 20210198221
    Abstract: Provided herein are compounds that can bind GAS5 long non-coding RNA, compositions thereof, and uses thereof.
    Type: Application
    Filed: December 15, 2016
    Publication date: July 1, 2021
    Applicants: University of South Florida, The United States Government as Represented by the Department of Veterans Affairs Office of General
    Inventors: Niketa A. Patel, Jianfeng Cai
  • Exosomes from human adipose-derived stem cells for the treatment of brain injury
    Patent number: 10857187
    Abstract: Brain injury can be caused by trauma or may occur in stroke or neurodegenerative diseases. The disclosure relates to compositions that can include exosomes isolated from human adipose-derived stem cells (hASC) and methods where exosomes from hASC may be used alone or in combination with insulin for the treatment of brain injury.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: December 8, 2020
    Assignee: University of South Florida
    Inventors: Niketa A. Patel, Paula Cole Bickford
  • Sortilin-binding small molecules for increasing glucose uptake
    Patent number: 10849896
    Abstract: Various scaffolds of small molecules capable of binding to the active site of sortilin are identified by in silico methods. These scaffolds include norbornene anhydride amino acid adducts and 2-substituted 3-oxo-1,2,3,4-tetrahydro-2-quinoxalines. These sortilin ligands increase the uptake of glucose in 3T3L1 cells and can be employed in compositions to increase uptake of glucose for the treatment of diabetic patents.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: December 1, 2020
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Niketa A. Patel, Robert Pleasants Sparks, Wayne Charles Guida
  • Methods and compositions for diagnosis and management of diabetes and metabolic syndrome
    Patent number: 10724097
    Abstract: Described herein are assays, methods, and devices for diagnosing/prognosing diabetes, metabolic syndrome, pre-diabetic state and/or the early-onset of diabetes in a subject. The assays, methods, and devices described herein can be configured to detect one or more long-coding RNAs in a sample from a subject.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: July 28, 2020
    Assignees: University of South Florida, The United States Government as Represented by the Department of Veterans Affairs Office of General Counsel
    Inventor: Niketa A. Patel
  • ADIPOSE DERIVED STEM CELL EXOSOMES AND USES THEREOF
    Publication number: 20190192576
    Abstract: Provided herein are exosomal compositions and exsosomal IncRNA compositions and formulations thereof. Also provided herein are methods of treating a wound in a subject in need thereof that can contain the step of administering an exosomal composition and/or exsosomal IncRNA compositions or formulation thereof to a wound in a subject in need thereof.
    Type: Application
    Filed: August 30, 2017
    Publication date: June 27, 2019
    Applicants: University of South Florida, The United States Government as Represented by The Department of Veterans Affairs Offairs Office of
    Inventors: DENISE R. COOPER, LISA GOULD, NIKETA PATEL, MACK WU
  • PKC-DELTA-I INHIBITOR FORMULATIONS AND USES THEREOF
    Publication number: 20190091201
    Abstract: Provided herein are formulations that can contain an effective amount of a PKC? inhibitor. Also provided herein are methods of inhibiting a PKC? in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKC?.
    Type: Application
    Filed: March 15, 2017
    Publication date: March 28, 2019
    Applicant: University of South Florida
    Inventors: NIKETA A. PATEL, REKHA S. PATEL, ROBERT PLEASANTS SPARKS, WAYNE CHARLES GUIDA
  • Method of characterizing and manipulating adipose stem cell depots to a metabolically healthy state
    Patent number: 10196612
    Abstract: A method of reprogramming omental adipose cells to a subcutaneous-like lineage is presented herein. The method comprises exposing omental adipose cells to a small molecule such as Basic Fibroblast Growth Factor (bFGF); TRC105; long noncoding RNAs (lncRNAs) MALAT1, GAS5, linc-VLDLR; transcription factors Sox15, Oct4, KLF4, Nanog, Sal4, BMI1; or combinations thereof.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: February 5, 2019
    Assignees: University of South Florida, The United States of America as Represented by the Department of Veterens Affairs
    Inventors: Niketa A. Patel, Ghattas El Bassit
  • EXOSOMES FROM HUMAN ADIPOSE-DERIVED STEM CELLS FOR THE TREATMENT OF BRAIN INJURY
    Publication number: 20180360888
    Abstract: The invention relates to compositions comprising exosomes isolated from hASC and their use in a method of treating brain injury in a subject.
    Type: Application
    Filed: June 18, 2018
    Publication date: December 20, 2018
    Applicant: University of South Florida
    Inventors: Niketa A. Patel, Paula Cole Bickford
  • Sortilin-Binding Small Molecules for Increasing Glucose Uptake
    Publication number: 20180318296
    Abstract: Various scaffolds of small molecules capable of binding to the active site of sortilin are identified by in silico methods. These scaffolds include norbornene anhydride amino acid adducts and 2-substituted 3-oxo-1,2,3,4-tetrahydro-2-quinoxalines. These sortilin ligands increase the uptake of glucose in 3T3L1 cells and can be employed in compositions to increase uptake of glucose for the treatment of diabetic patents.
    Type: Application
    Filed: June 29, 2018
    Publication date: November 8, 2018
    Inventors: Niketa A. Patel, Robert Pleasants Sparks, Wayne Charles Guida
  • Method of treating neurological disorders using long non-coding RNAs
    Patent number: 9822359
    Abstract: A method of treating traumatic brain injury (TBI) and other neurological disorders is presented herein. Both conditioned media (CM) containing long non-coding RNAs such as NEAT1 (nuclear enriched abundant transcript 1) and MALAT1 (metastasis associated lung adenocarcinoma transcript 1) as well as human adipose-derived stem cells (hADSCs) themselves (Tx), when administered at least 3 hours post injury, were found to significantly ameliorate motor and cognitive functions in young, but not aged, mice undergoing TBI. Significant reduction in cortical damage and hippocampal cell loss was observed in both Tx and CM groups in young rats, whereas less neuroprotection was detected in the aged rats and mainly in the Tx group but not the CM group, which may in part result from decreased homing of the cells to the spleen.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: November 21, 2017
    Assignees: University of South Florida, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Denise R. Cooper, Cesario Borlongan, Paula Cole Bickford, Niketa A. Patel, Lisa Gould
  • METHODS AND COMPOSITIONS FOR DIAGNOSIS AND MANAGEMENT OF DIABETES AND METABOLIC SYNDROME
    Publication number: 20170321277
    Abstract: Described herein are assays, methods, and devices for diagnosing/prognosing diabetes, metabolic syndrome, pre-diabetic state and/or the early-onset of diabetes in a subject. The assays, methods, and devices described herein can be configured to detect one or more long-coding RNAs in a sample from a subject.
    Type: Application
    Filed: November 30, 2015
    Publication date: November 9, 2017
    Applicants: University of South Florida, THE U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTME NT OF VETERANS AFFAIRS OFFICE OF GENERAL COUNSEL
    Inventor: NIKETA A. PATEL
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 9724343
    Abstract: The present invention provides a compound of formua I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: August 8, 2017
    Assignee: Wyeth, LLC
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20170007597
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: September 26, 2016
    Publication date: January 12, 2017
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu