Abstract: Described are pharmaceutical compositions in fixed dose combinations containing: a) a dofetilide component; and b) a mexiletine component; wherein the dofetilide component and the mexiletine component are physically separated from each other, along with methods of treating or preventing atrial fibrillation or a symptom associated therewith in a subject in need thereof by administering to the subject such a pharmaceutical composition and methods of preparing such fixed dose combination products.

Abstract: A method performed by a surgical system. The method determines a resonance frequency of an end effector of an ultrasonic instrument, and determines whether the end effector of the ultrasonic instrument is in a heating state or a cooling state. Responsive to determining that the end effector is in the heating state, the method estimates a temperature of the end effector based on output of a first temperature model that has input based on the resonance frequency. Responsive, however, to determining that the end effector is in the cooling state, the method estimates the temperature of the end effector based on output of a second temperature model that has input based on the resonance frequency. The method presents a notification based on the estimated temperature.