Patents by Inventor Nikhil SANGITH

Nikhil SANGITH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED SHIGELLA APYRASE AND USES THEREOF
    Publication number: 20240167005
    Abstract: An apyrase enzyme, characterized by that the apyrase comprises a polypeptide sequence having at least 70% sequence identity to the wild-type Shigella flexneri apyrase of SEQ ID NO:1, wherein said sequence differs from SEQ ID NO:1 at least in that the sequence comprises at least one amino-acid substitution of a residue aligning with a residue selected from: F53, L66 and E77; and the apyrase catalyzes the dephosphorylation of at least one organic phosphate with at least 10-fold lower Km compared to the apyrase of SEQ ID NO:1. Uses of said apyrase in ATP elimination and dephosphorylation of organic phosphates.
    Type: Application
    Filed: March 15, 2022
    Publication date: May 23, 2024
    Inventors: Pavankumar ASALAPURAM RAMACHANDRAN, Nikhil SANGITH
  • PRODUCTION OF L-2-AMINOBUTYRATE FROM CITRAMALATE,CITRACONATE OR 2-OXOBUTANOATE
    Publication number: 20220243233
    Abstract: The present invention relates to preparation of key drug intermediate, L-2-amino butyric acid (L-2-ABA) by a method of cell free system and biotransformation using genetically engineered strains from easily available economic substrates like citramalate or citraconate and enzymes like LeuCD, LeuB and ValDH or IlvE.
    Type: Application
    Filed: October 4, 2019
    Publication date: August 4, 2022
    Applicant: ANNA UNIVERSITY
    Inventors: Akila T., Padmapriya G., Anitha Janet Roshni Y., Tamilselvan J., Nikhil SANGITH, Mahalakshmi NATARAJAN, Pandiraj SUPPURAM, Ramalingam S.