Abstract: A light-sheet fluorescence microscope has a laser producing a light beam, two objective lenses arranged with their optical axes in different directions to provide different views, a scanning mirror configured to direct the light beam into distinct portions of an optical path, a beam combining/separating component configured to direct the light beam in the distinct portions of the optical path alternately into each of the two objective lenses and to combine detection light from the two objective lenses into the distinct portions of the optical path, a dichroic mirror that separates the light beam from detection light, and a camera sensor focused simultaneously on the focal planes of said two objective lenses. Embodiments may also include an adaptive optics or fixed corrective element.

Abstract: The present invention relates to the field of cancer therapy. Specifically, a chemotaxis fusion-receptor that directs bacteria towards tumors is disclosed. Further encompassed by the present invention is a bacterial cell that comprises at least one chemotaxis fusion-receptor and, preferably, a killing module for the destruction of tumor cells.