Patents by Inventor Nikki Ross
Nikki Ross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11992527Abstract: The present disclosure relates to extracellular vesicles (EVs), e.g., exosomes, comprising a payload (e.g., an antigen, adjuvant, and/or immune modulator) and/or a targeting moiety. Also provided herein are methods for producing the EVs (e.g., exosomes) and methods for using the EVs (e.g., exosomes) to treat and/or prevent diseases or disorders, e.g., cancer, graft-versus-host disease (GvHD), autoimmune disease, infectious diseases, or fibrotic diseases.Type: GrantFiled: October 26, 2022Date of Patent: May 28, 2024Assignee: LONZA SALES AGInventors: Raymond J. Moniz, Russell E. McConnell, Nikki Ross, Christine McCoy, Timothy J. Soos, Ke Xu
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Publication number: 20240009322Abstract: The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.Type: ApplicationFiled: October 26, 2022Publication date: January 11, 2024Applicant: LONZA SALES AGInventors: Kevin P. DOOLEY, Rane A. HARRISON, Russell E. MCCONNELL, Ke XU, Damian J. HOUDE, Nikki ROSS, Sonya HAUPT, John D. KULMAN, Douglas E. WILLIAMS
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Publication number: 20230263885Abstract: The present disclosure relates to extracellular vesicles (EVs), e.g., exosomes, comprising a payload (e.g., an antigen, adjuvant, and/or immune modulator) and/or a targeting moiety. Also provided herein are methods for producing the EVs (e.g., exosomes) and methods for using the EVs (e.g., exosomes) to treat and/or prevent diseases or disorders, e.g., cancer, graft-versus-host disease (GvHD), autoimmune disease, infectious diseases, or fibrotic diseases.Type: ApplicationFiled: October 26, 2022Publication date: August 24, 2023Applicant: Codiak BioSciences, Inc.Inventors: Raymond J. MONIZ, Russell E. MCCONNELL, Nikki ROSS, Christine MCCOY, Timothy J. SOOS, Ke XU
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Patent number: 11679164Abstract: The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.Type: GrantFiled: December 20, 2019Date of Patent: June 20, 2023Assignee: CODIAK BIOSCIENCES, INC.Inventors: Kevin P. Dooley, Rane A. Harrison, Russell E. McConnell, Ke Xu, Damian J. Houde, Nikki Ross, Sonya Haupt, John D. Kulman, Douglas E. Williams
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Publication number: 20230181758Abstract: The present disclosure relates to modified extracellular vesicles, e.g., exosomes, comprising a targeting moiety, wherein the targeting moiety can specifically bind to markers expressed on distinct immune cells (e.g., dendritic cells). Also provided herein are methods for using the exosomes to treat and/or prevent a range of medical disorders.Type: ApplicationFiled: August 23, 2019Publication date: June 15, 2023Applicant: Codiak BioSciences, Inc.Inventors: Nikki ROSS, Dalia BURZYN, Sriram SATHYANARAYANAN, Raymond J. MONIZ, Ke XU, Shelly Ann MARTIN, Kevin DOOLEY
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Publication number: 20230114434Abstract: The present disclosure relates to extracellular vesicles (EVs) that are capable of targeting a cell in the CNS of a subject. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent diseases or disorders of the CNS (e.g., neurological disorders).Type: ApplicationFiled: March 15, 2021Publication date: April 13, 2023Applicant: Codiak BioSciences, Inc.Inventors: Ajay VERMA, Tim SOOS, Nikki ROSS, Christine MCCOY, Jonathan FINN, Sriram SATHYANARAYANAN, Shailendra PATEL, Ke XU, Russell E. MCCONNELL, Kevin P. DOOLEY
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Publication number: 20220168415Abstract: The present disclosure relates to extracellular vesicles (EVs), e.g., exosomes, comprising a payload (e.g., an antigen, adjuvant, and/or immune modulator) and/or a targeting moiety. Also provided herein are methods for producing the EVs (e.g., exosomes) and methods for using the EVs (e.g., exosomes) to treat and/or prevent diseases or disorders, e.g., cancer, graft-versus-host disease (GvHD), autoimmune disease, infectious diseases, or fibrotic diseases.Type: ApplicationFiled: March 20, 2020Publication date: June 2, 2022Applicant: Codiak BioSciences, Inc.Inventors: Raymond J. MONIZ, Russell E. MCCONNELL, Nikki ROSS, Christine MCCOY, Timothy J. SOOS, Ke XU
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Publication number: 20200222556Abstract: The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.Type: ApplicationFiled: December 20, 2019Publication date: July 16, 2020Applicant: Codiak BioSciences, Inc.Inventors: Kevin P. DOOLEY, Rane A. HARRISON, Russell E. MCCONNELL, Ke XU, Damian J. HOUDE, Nikki ROSS, Sonya HAUPT, John D. KULMAN, Douglas E. WILLIAMS
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Patent number: 10561740Abstract: The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.Type: GrantFiled: December 21, 2018Date of Patent: February 18, 2020Inventors: Kevin P. Dooley, Rane A. Harrison, Russell E. McConnell, Ke Xu, Damian J. Houde, Nikki Ross, Sonya Haupt, John D. Kulman, Douglas E. Williams
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Publication number: 20190117792Abstract: The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.Type: ApplicationFiled: December 21, 2018Publication date: April 25, 2019Inventors: Kevin P. Dooley, Rane A. Harrison, Russell E. McConnell, Ke Xu, Damian J. Houde, Nikki Ross, Sonya Haupt, John D. Kulman, Douglas E. Williams
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Publication number: 20190060483Abstract: The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.Type: ApplicationFiled: August 24, 2018Publication date: February 28, 2019Inventors: Kevin P. Dooley, Rane A. Harrison, Russell E. McConnell, Ke Xu, Damian J. Houde, Nikki Ross, Sonya Haupt, John D. Kulman, Douglas E. Williams
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Patent number: 10195290Abstract: The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.Type: GrantFiled: August 24, 2018Date of Patent: February 5, 2019Assignee: Codiak BioSciences, Inc.Inventors: Kevin P. Dooley, Rane A. Harrison, Russell E. McConnell, Ke Xu, Damian J. Houde, Nikki Ross, Sonya Haupt, John D. Kulman, Douglas E. Williams