Abstract: The present invention relates to a new method for producing a calcium sulphate hemihydrate with unique properties for use for therapeutic applications in the cosmetic or pharmaceutical industry. Calcium sulphate hemihydrate is a biocompatible and biodegradable inorganic substance and thus suitable as a carrier in pharmaceutical compositions, e.g. a controlled release composition, containing at least one pharmaceutically active ingredient.

Abstract: The present invention relates to a new method for producing a calcium sulphate hemihydrate with unique properties for use for therapeutic applications in the cosmetic or pharmaceutical industry. Calcium sulphate hemihydrate is a biocompatible and biodegradable inorganic substance and thus suitable as a carrier in pharmaceutical compositions, e.g. a controlled release composition, containing at least one pharmaceutically active ingredient.

Abstract: The present invention relates to a new method for producing a calcium sulphate hemihydrate with unique properties for use for therapeutic applications in the cosmetic or pharmaceutical industry. Calcium sulphate hemihydrate is a biocompatible and biodegradable inorganic substance and thus suitable as a carrier in pharmaceutical compositions, e.g. a controlled release composition, containing at least one pharmaceutically active ingredient.

Abstract: The present invention relates to a new method for producing a calcium sulphate hemihydrate with unique properties for use for therapeutic applications in the cosmetic or pharmaceutical industry. Calcium sulphate hemihydrate is a biocompatible and biodegradable inorganic substance and thus suitable as a carrier in pharmaceutical compositions, e.g. a controlled release composition, containing at least one pharmaceutically active ingredient.

Abstract: A dental implant unit includes a layer of synthetically created titanium dioxide. The dental implant unit has one end for connection and a lateral surface covering the implant unit except for the end for connection. The lateral surface includes a layer of synthetically created titanium dioxide while the end for connection is free from synthetically created titanium dioxide. Also, a method produces a whitened implantable dental unit. The method includes thermal oxidation of a dental implant unit that includes titanium.

Abstract: A dental implant unit includes a layer of synthetically created titanium dioxide. The dental implant unit has one end for connection and a lateral surface covering the implant unit except for the end for connection. The lateral surface includes a layer of synthetically created titanium dioxide while the end for connection is free from synthetically created titanium dioxide. Also, a method produces a whitened implantable dental unit. The method includes thermal oxidation of a dental implant unit that includes titanium.

Abstract: Carboxymethylcellulose, notably sodium carboxymethylcellulose or other alkali metal or alkaline earth metal salts of carboxymethylcellulose, are employed to control solidification time of compositions comprising one or more bioresorbable ceramics, notably a hydratable calcium sulphate, in order to facilitate preparation of a ready-to-use composition for inserting into the body by injection.

Abstract: The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.

Abstract: A novel method for the preparation of a highly densified and at least partly, preferably fully or almost fully hydrated ceramic for use in the preparation of a pharmaceutical composition notably for controlled-release of one or more therapeutically, prophylactically and/or diagnostically active substance. The method involves a concomitant step of hydrating and densifying a bioresorbable and hydratable ceramic such as calcium sulphate. The invention also relates to compositions comprising such a highly densified ceramic. The pharmaceutical composition is useful for targeted and controlled local prolonged release of active substances, e.g. anti-cancer agents, whereby the spectrum and severity of side effects are minimized due to an optimized local concentration-time profile.

Abstract: A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs, and ii) administering locally into the prostate a controlled release pharmaceutical composition comprising one or more active substances in a biodegradable ceramic carrier. The biodegradable hydrating ceramic may be selected from the group consisting of non-hydrated or hydrated calcium sulphate, calcium phosphate, calcium carbonate, calcium fluoride, calcium silicate, magnesium sulphate, magnesium phosphate, magnesium carbonate, magnesium fluoride, magnesium silicate, barium sulphate, barium phosphate, barium carbonate, barium fluoride, barium silicate, or mixtures thereof. In a specific embodiment, the biodegradable hydrating ceramic is non-hydrated or hydrated calcium sulphate.

Abstract: An implant with anti-inflammatory or antibacterial effects, or both, for implantation in a human or animal body, the implant having a set of porous grains or granules, wherein at least a plurality of the porous grains or granules include titanium, one or more titanium oxides or titanium alloy and have a titanium oxide layer on their surface and have a mean length from one side to the opposite side, through a geometrical center, of at least 200 ?m and up to 5 mm and a mean specific surface area of at least 0.15 m2/g according to the BET method. Also featured is a population of grains or granules having anti-inflammatory or antibacterial effects, or both. Further featured is a method of producing an implant, a method for deriving a population of grains or granules, and a method for treating a condition with a porous grain or granule.

Abstract: Embodiments of the present disclosure are directed to a systems, devices and methods for displacing bones of a living mammal. In some embodiments, a device is provided which includes at least two engagement elements positioned at a distance from each other for engagement with two separate bones Each of the engagement elements may be carried by a support part which in turn is supported in a support portion of a distance unit (5). The said support part and support portion form a support unit, where each engagement element extends at an angle (?) with respect to a straight line (L) between two support units. At least one of the support units includes an arrangement for altering the angle which includes an actuating unit maneuverable for adjustment of the angle (?). Some embodiments of the disclosure are directed to a system for engagement with vertebrae including such devices (noted above), as well as uses of the device and associated methods of treatment.

Abstract: An injector device is disclosed, the injector device comprising an elongated mixing container extending along a first axis, and a piston member slidably positioned in the mixing container. The injector device comprises a mixing device comprising a mixing member, an elongated member parallel to the first axis and a handle member. The piston member comprises a piston head and a first locking arm flexibly connected to the piston head, such that the first locking arm in a first position extends substantially parallel to the elongated member and engages with the mixing device in such a way that the piston member moves in a first direction along the first axis with the mixing device. In a second position, the first locking arm may allow the mixing device to move relative to the mixing container independently of the piston member.

Abstract: A system and a method for making an injectable mixture using at least one first pulverulent component and a second liquid component with a first piston/cylinder arrangement with a cylinder with an axial extension and a piston, wherein the cylinder includes a measured amount of the pulverulent component, a separate reservoir including a corresponding measured amount of the liquid component, and a transfer device for sealed transfer of said amount of the liquid component to the cylinder for subsequent mixing and injection of the completed mixture. The first piston/cylinder arrangement is an injection syringe. A mixing element being manoeuvrable by a user is positioned inside the cylinder. At least one gas transferring channel means leading to the cylinder is arranged at the cylinder. Engagement means are arranged for connecting the first injection syringe to the separate reservoir during transfer of the liquid component.

Abstract: The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.

Abstract: A positioning device for placing a prosthesis device in a spinal column of a living mammal, the device including at least one holding means for cooperation with the prosthesis device and for guiding thereof during positioning. The positioning device may also include fixing means for fixation with respect to at least one vertebra, where the fixing means includes locking means, which in a first, free state, allows adjustable movement of the holding device and thereby of the prosthesis device, and in a second, locked state, fixes the holding means and thereby the prosthesis device in a selected position. Embodiments of the disclosure also include Embodiments of the invention also include a system.

Abstract: The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.

Abstract: An injector device is disclosed, the injector device comprising an elongated mixing container extending along a first axis, and a piston member slidably positioned in the mixing container. The injector device comprises a mixing device comprising a mixing member, an elongated member parallel to the first axis and a handle member. The piston member comprises a piston head and a first locking arm flexibly connected to the piston head, such that the first locking arm in a first position extends substantially parallel to the elongated member and engages with the mixing device in such a way that the piston member moves in a first direction along the first axis with the mixing device. In a second position, the first locking arm may allow the mixing device to move relative to the mixing container independently of the piston member.

Abstract: Carboxymethylcellulose, notably sodium carboxymethylcellulose or other alkali metal or alkaline earth metal salts of carboxymethylcellulose, are employed to control solidification time of compositions comprising one or more bioresorbable ceramics, notably a hydratable calcium sulphate, in order to facilitate preparation of a ready-to-use composition for inserting into the body by injection.

Abstract: Device (1) for displacing bones of a living mammal, including at least two engagement elements (2?7 2?), positioned at a distance from each other, for engagement with two separate bones, wherein each one of said engagement elements (2?, 2?) is carried by a support part (3?, 3?) which in turn is supported in a support portion (4?, 4?) of a distance unit (5), said support part and support portion forming a support unit, wherein each engagement element (2?, 2?) extends at an angle (?) with respect to a straight line (L) between two support units, and wherein at least one of said support units includes an arrangement for altering said angle. Said arrangement for altering said angle includes an actuating unit (V, 7?, 9?, 9?, 10?, 10?) which is maneuverable for adjustment of said angle (?). The invention also concerns a system for engagement with vertebrae including such a device and a use of the device.