Abstract: Systems and methods for perfusing a treatment solution into the blood stream of particular organs while isolating those organs from the systemic vasculature as a whole. By deploying both collection and supply catheters, some having balloons on their distal ends, to particular locations within the body, various organs can be isolated so that the treatment solution can be delivered directly thereto. By isolating the organs, any side effects that may occur from a systemic introduction of the treatment solution are avoided. The method may be used to isolate not just organs, but specific tumors within certain organs for oncology treatment.

Abstract: Systems and methods for perfusing a treatment solution into the blood stream of particular organs while isolating those organs from the systemic vasculature as a whole. By deploying both collection and supply catheters, some having balloons on their distal ends, to particular locations within the body, various organs can be isolated so that the treatment solution can be delivered directly thereto. By isolating the organs, any side effects that may occur from a systemic introduction of the treatment solution are avoided. The method may be used to isolate not just organs, but specific tumors within certain organs for oncology treatment.

Abstract: An implantable sensor (1) for determining at least one parameter, in particular a physical parameter, comprises a sensor body (3). The sensor body (3) is responsive to the at least one parameter and is configured to yield at least one response signal (SR) upon an interrogation of the sensor body (3) with at least one interrogation signal (SI) comprising acoustic waves. The at least one response signal (SR) is associated with the at least one parameter. The sensor body (3) comprises or consists of at least one material having an ordered structure (4). The at least one response signal (SR) is associated with one or more bulk effects of the at least one material having an ordered structure (4).

Abstract: An implant system for capturing a regurgitant jet to effect preserving the atrioventricular pressure gradient and ventricular remodeling in a human heart including an expandable implant for positioning in the atrial/ventricular valve of the human heart and at least partially within the atrium and/or the ventricle, the expandable implant defining a first position for at least partially capturing the atrioventricular pressure gradient and regurgitant trans-valvular blood flow and associated driving forces during systole and a second position for steering flow from the atrium to the ventricle to enhance vorticular flow during diastole; a therapeutic apical base plate attachable to the apex of the heart; and a tethering conduit connected between the expandable implant and the therapeutic apical base plate assembly that transducts the energy and/or forces of captured regurgitant trans-valvular blood flow or atrioventricular pressure to the structures of the ventricle and the ventricular wall.

Abstract: An implant system for improving physiological cardiac flow in a human heart is provided including an inflatable implant for positioning at least partially within an atrium, a ventricle and a atrial/ventricular valve of the human heart and defining a surface for intercepting and redirecting hemodynamic flow into the ventricle, the inflatable implant defining a surface to engage the valve; a therapeutic apical base plate assembly attachable to the apex of the heart; and a tether connected between the inflatable implant and the therapeutic apical base plate assembly. The inflatable implant and the therapeutic apical base plate assembly are configured to reshape the ventricular wall by transducting cardiac force and/or energy generated by the heart during systole and diastole when the inflatable implant is engaged with the valve and of the therapeutic apical base plate assembly is attached to the apex.

Abstract: An implant system for improving physiological cardiac flow in a human heart is provided including an inflatable implant for positioning at least partially within an atrium, a ventricle and a atrial/ventricular valve of the human heart and defining a surface for intercepting and redirecting hemodynamic flow into the ventricle, the inflatable implant defining a surface to engage the valve; a therapeutic apical base plate assembly attachable to the apex of the heart; and a tether connected between the inflatable implant and the therapeutic apical base plate assembly. The inflatable implant and the therapeutic apical base plate assembly are configured to reshape the ventricular wall by transducting cardiac force and/or energy generated by the heart during systole and diastole when the inflatable implant is engaged with the valve and of the therapeutic apical base plate assembly is attached to the apex.

Abstract: An implant system for capturing a regurgitant jet to effect preserving the atrioventricular pressure gradient and ventricular remodeling in a human heart including an expandable implant for positioning in the atrial/ventricular valve of the human heart and at least partially within the atrium and/or the ventricle, the expandable implant defining a first position for at least partially capturing the atrioventricular pressure gradient and regurgitant trans-valvular blood flow and associated driving forces during systole and a second position for steering flow from the atrium to the ventricle to enhance vorticular flow during diastole; a therapeutic apical base plate attachable to the apex of the heart; and a tethering conduit connected between the expandable implant and the therapeutic apical base plate assembly that transducts the energy and/or forces of captured regurgitant trans-valvular blood flow or atrioventricular pressure to the structures of the ventricle and the ventricular wall.