Patents by Inventor Nikolai F. Sepetov

Nikolai F. Sepetov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6799120
    Abstract: The present invention includes methods for generating combinatorial libraries on solid phase supports in which increased productivity is achieved by pooling all common steps in synthesis without using a tracking or coding system to record the synthetic history of each compound. Methods for generating combinatorial libraries in which containers with random mixtures of solid phase particles are divided and combined together in non-random ways without the exchange of particles between containers are also provided. Various products are optionally produced in multi-stage syntheses according to the invention, such as oligomers and synthetic non-repetitive organic molecules. The methods additionally relate to the identification of each library component without adding extra synthetic, physical, optical, or electronic encoding steps during library synthesis. Combinatorial synthetic systems are also provided.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: September 28, 2004
    Assignee: Nanoscale Combinatorial Synthesis, Inc.
    Inventors: Nikolai F. Sepetov, Olga L. Issakova, Stephen A. Baum, James A. Ostrem
  • Patent number: 6625546
    Abstract: Methods of identifying predicted or actual structures of members of a chemical or physical library are provided. The methods provide for the direct identification of compound structure following combinatorial synthesis using molecular mass measurements of individual compounds, thereby eliminating the necessity of encoding synthetic steps. The analysis of mass spectrometric data for sets of related compounds reveals compounds that are missing in a group of related compounds and identifies compounds that do not belong to a group of related compounds due to unexpected chemical, physical, or biological transformations. The methods may be applied to any group of compounds originating from chemical reactions where one reactant is common to the synthetic transformation. One particular application of these methods is in the analysis of the products of combinatorial synthesis. Systems, computer programs products, and kits are additionally provided.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: September 23, 2003
    Assignee: Nanoscale Combinatorial Synthesis, Inc.
    Inventors: Nikolai F. Sepetov, Olga L. Issakova
  • Publication number: 20020051999
    Abstract: Methods of identifying predicted or actual structures of members of a chemical or physical library are provided. The methods provide for the direct identification of compound structure following combinatorial synthesis using molecular mass measurements of individual compounds, thereby eliminating the necessity of encoding synthetic steps. The analysis of mass spectrometric data for sets of related compounds reveals compounds that are missing in a group of related compounds and identifies compounds that do not belong to a group of related compounds due to unexpected chemical, physical, or biological transformations. The methods may be applied to any group of compounds originating from chemical reactions where one reactant is common to the synthetic transformation. One particular application of these methods is in the analysis of the products of combinatorial synthesis. Systems, computer programs products, and kits are additionally provided.
    Type: Application
    Filed: February 2, 2001
    Publication date: May 2, 2002
    Inventors: Nikolai F. Sepetov, Olga L. Issakova
  • Publication number: 20010041344
    Abstract: The present invention includes methods for generating combinatorial libraries on solid phase supports in which increased productivity is achieved by pooling all common steps in synthesis without using a tracking or coding system to record the synthetic history of each compound. Methods for generating combinatorial libraries in which containers with random mixtures of solid phase particles are divided and combined together in non-random ways without the exchange of particles between containers are also provided. Various products are optionally produced in multi-stage syntheses according to the invention, such as oligomers and synthetic non-repetitive organic molecules. The methods additionally relate to the identification of each library component without adding extra synthetic, physical, optical, or electronic encoding steps during library synthesis. Combinatorial synthetic systems are also provided.
    Type: Application
    Filed: February 2, 2001
    Publication date: November 15, 2001
    Applicant: Nanoscale Combinatorial Synthesis, Inc., 625 Clyde Avenue, Mountain View, CA 94043
    Inventors: Nikolai F. Sepetov, Olga L. Issakova, Stephen A. Baum, James A. Ostrem