Patents by Inventor Nikolai N. Polouchine

Nikolai N. Polouchine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multiple methoxyoxalamido and succinimido precursors for nucleophilic addition
    Patent number: 6747142
    Abstract: Compounds and the synthesis of compounds containing multiple precursor groups and allowing the efficient synthesis of highly functionalized oligonucleotides and oligomers are provided. Also, a branching unit that helps to further increase the density of functional groups on synthetic oligonucleotides and oligomers is provided.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: June 8, 2004
    Assignee: Fidelity Systems, Inc.
    Inventor: Nikolai N. Polouchine
  • Inhibition of molecular and biological processes using modified oligonucleotides
    Patent number: 6548251
    Abstract: A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): A—Xn  (I) wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of —NRCOCONu, —NHCOCR2CR2CONu, —NHCOCR═CRCONu, and —NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: April 15, 2003
    Assignee: Fidelity Systems, Inc.
    Inventors: Sergei A. Kozyavkin, Andrei G. Malykh, Nikolai N. Polouchine, Alexei I. Slesarev
  • Methoxyoxalamido and succinimido precursors for nucleophilic addition to nucleosides, nucleotides and oligonucleotides
    Patent number: 5902879
    Abstract: Moieties, including a 2'-methoxyoxalamido and N-succinimido moieties, were incorporated into a compound, particularly an oligonucleotide molecule. The moieties were shown to be useful precursors for the post synthetic introduction of various functional additives.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: May 11, 1999
    Assignee: Fidelity Systems, Inc.
    Inventor: Nikolai N. Polouchine