Patents by Inventor Nikolai Naryshkin

Nikolai Naryshkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for treating spinal muscular atrophy
    Patent number: 9399649
    Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: July 26, 2016
    Assignee: PTC Therapeutics, Inc.
    Inventors: Guangming Chen, Amal Dakka, Gary Mitchell Karp, Chunshi Li, Jana Narasimhan, Nikolai Naryshkin, Marla L. Weetall, Ellen Welch, Xin Zhao
  • Methods of screening for compounds for treating muscular dystrophy using human ALPHA7 integrin mRNA translation regulation
    Patent number: 9376725
    Abstract: The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of muscular mystrophy (MD), or a form thereof, in which said compounds increase the post-transcriptional expression of a target gene (i.e., mIGF1, ITGA7, or UTRN).
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: June 28, 2016
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Westley J. Friesen, Nikolai Naryshkin, Meenal Patel, Charles Romfo, Yuki Tomizawa, Ellen Welch, Jin Zhuo
  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20160145270
    Abstract: The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: June 23, 2014
    Publication date: May 26, 2016
    Applicants: F. Hoffmann-La Roche AG, PTC Therapeutics Inc.
    Inventors: Amal Dakka, Luke Green, Gary Karp, Jana Narasimhan, Nikolai Naryshkin, Emmanuel Pinard, Hongyan Qi, Hasane Ratni, Nicole Risher, Marla Weetall, Matthew Woll
  • METHODS FOR TREATING VIRAL INFECTIONS
    Publication number: 20150344877
    Abstract: The present invention relates to compounds that modulate ribosomal frameshifting and nucleic acid constructs for use in methods for identifying or validation such compounds. In particular, the present invention relates to the use of nucleic acid constructs to identify or validate compounds capable of modulating the efficiency of programmed ribosomal frameshifting and the use of said compounds to inhibit the replication or infectivity of viruses that employ programmed ribosomal frameshifting.
    Type: Application
    Filed: May 12, 2015
    Publication date: December 3, 2015
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Sergey V. Paushkin, Nikolai A. Naryshkin, Ellen Welch
  • METHODS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20150283115
    Abstract: Described herein are methods for the identification or validation of compounds capable of causing ribosomal frameshifting and the use of said compounds to produce a stabilized SMN?Ex7 protein and treat Spinal Muscular Dystrophy.
    Type: Application
    Filed: February 12, 2015
    Publication date: October 8, 2015
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Sergey V. Paushkin, Nikolai A. Naryshkin, Ellen Welch
  • Methods And Agents For Screening For Compounds Capable Of Modulating Gene Expression
    Publication number: 20150253304
    Abstract: The invention relates to the fields of screening assays, compounds, and methods for altering gene expression and protein levels. In particular, the invention includes assays to screen for agents capable of modulating gene expression in a UTR-dependent manner and agents capable of modulating gene expression.
    Type: Application
    Filed: May 22, 2015
    Publication date: September 10, 2015
    Applicant: PTC Therapeutics, Inc.
    Inventors: Liangxian Cao, Nikolai Naryshkin, Charles Romfo, Matthew C. Pelligrini, Anuradha Mehta, Panayiota Trifillis, Christopher R. Trotta
  • Methods and agents for screening for compounds capable of modulating gene expression
    Patent number: 9068234
    Abstract: The invention relates to the fields of screening assays, compounds, and methods for altering gene expression and protein levels. In particular, the invention includes assays to screen for agents capable of modulating gene expression in a UTR-dependent manner and agents capable of modulating gene expression.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: June 30, 2015
    Assignee: PTC Therapeutics, Inc.
    Inventors: Liangxian Cao, Anuradha Mehta, Nikolai A. Naryshkin, Matthew C. Pellegrini, Charles M. Romfo, Panayiota Trifillis, Christopher R. Trotta
  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20150126515
    Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Application
    Filed: January 25, 2013
    Publication date: May 7, 2015
    Applicant: PTC Therapeutics, Inc.
    Inventors: Guangming Chen, Amal Dakka, Gary Mitchell Karp, Chunshi Li, Jana Narasimhan, Nikolai Naryshkin, Marla L. Weetall, Ellen Welch, Xin Zhao
  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20150119380
    Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.
    Type: Application
    Filed: December 28, 2012
    Publication date: April 30, 2015
    Inventors: Matthew G. Woll, Guangming Chen, Soongyu Choi, Amal Dakka, Song Huang, Gary Mitchell Karp, Chang-Sun Lee, Chunshi Li, Jana Narasimhan, Nikolai Naryshkin, Sergey Paushkin, Hongyan Qi, Anthony A. Turpoff, Marla L. Weetall, Ellen Welch, Tianle Yang, Nanjing Zhang, Xiaoyan Zhang, Xin Zhao, Emmanuel Pinard, Hasane Ratni
  • Methods for treating spinal muscular atrophy
    Patent number: 8986935
    Abstract: Described herein are methods for the identification or validation of compounds capable of causing ribosomal frameshifting and the use of the compounds identified by the methods described herein to produce a stabilized SMN?Ex7 protein and treat Spinal Muscular Atrophy.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: March 24, 2015
    Assignee: PTC Therapeutics, Inc.
    Inventors: Sergey V. Paushkin, Nikolai A. Naryshkin, Ellen Welch
  • Screening assays for compounds that modulate programmed ribosomal frameshifting
    Patent number: 8932818
    Abstract: The present invention relates to compounds that modulate ribosomal frameshifting and nucleic acid constructs for use in methods for identifying or validation of compounds that modulate ribosomal frameshifting. In particular, the present invention relates to the use of nucleic acid constructs to identify or validate compounds capable of modulating the efficiency of programmed ribosomal frameshifting and the use of compounds that modulate the efficiency of programmed ribosomal frameshifting to inhibit the replication or infectivity of viruses that employ programmed ribosomal frameshifting.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: January 13, 2015
    Assignee: PTC Therapeutics, Inc.
    Inventors: Sergey V. Paushkin, Nikolai A. Naryshkin, Ellen Welch
  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20150005289
    Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Application
    Filed: February 8, 2013
    Publication date: January 1, 2015
    Inventors: Hongyan Qi, Soongyu Choi, Amal Dakka, Gary Mitchell Karp, Jana Narasimhan, Nikolai Naryshkin, Anthony A. Turpoff, Marla L. Weetall, Ellen Welch, Matthew G. Woll, Tianle Yang, Nanjing Zhang, Xiaoyan Zhang, Xin Zhao, Luke Green, Emmanuel Pinard, Hasane Ratni
  • Methods of screening for compounds for treating muscular dystrophy using mIGF1 mRNA translation regulation
    Patent number: 8741572
    Abstract: The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of muscular mystrophy (MD), or a form thereof, in which said compounds increase the post-transcriptional expression of a target gene (i.e., mIGF1, ITGA7, or UTRN).
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: June 3, 2014
    Assignee: PTC Therapeutics, Inc.
    Inventors: Westley J. Friesen, Nikolai Naryshkin, Meenal Patel, Charles Romfo, Yuki Tomizawa, Ellen Welch, Jin Zhou
  • METHODS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20140135305
    Abstract: The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene, compounds and pharmaceutical compositions that increase levels of SMN protein produced from the SMN2 gene, and methods for use thereof in treating of SMA.
    Type: Application
    Filed: December 12, 2013
    Publication date: May 15, 2014
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Sergey V. Paushkin, Charles Romfo, Ellen Welch, Nikolai Naryshkin
  • Methods for treating spinal muscular atrophy
    Patent number: 8633019
    Abstract: The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene, compounds and pharmaceutical compositions that increase levels of SMN protein produced from the SMN2 gene, and methods for use thereof in treating of SMA.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: January 21, 2014
    Assignee: PTC Therapeutics, Inc.
    Inventors: Sergey V. Paushkin, Nikolai Naryshkin, Charles Romfo, Ellen Welch
  • Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation
    Patent number: 8283115
    Abstract: The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of muscular dystrophy (MD), or a form thereof, in which said compounds increase the post-transcriptional expression of a target gene (i.e., mIGF1, ITGA7, or UTRN).
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: October 9, 2012
    Assignee: PTC Therapeutics, Inc.
    Inventors: Westley J Friesen, Nikolai Naryshkin, Meenal Patel, Charles Romfo, Ellen Welch, Yuki Tomizawa, Jin Zhuo
  • METHODS FOR TREATING VIRAL INFECTIONS
    Publication number: 20110213005
    Abstract: The present invention relates to compounds that modulate ribosomal frameshifting and nucleic acid constructs for use in methods for identifying or validation such compounds. In particular, the present invention relates to the use of nucleic acid constructs to identify or validate compounds capable of modulating the efficiency of programmed ribosomal frameshifting and the use of said compounds to inhibit the replication or infectivity of viruses that employ programmed ribosomal frameshifting.
    Type: Application
    Filed: August 13, 2009
    Publication date: September 1, 2011
    Inventors: Sergey V. Paushkin, Nikolai A. Naryshkin, Ellen Welch
  • METHODS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20110172284
    Abstract: Described herein are methods for the identification or validation of compounds capable of causing ribosomal frameshifting and the use of said compounds to produce a stabilized SMN?Ex7 protein and treat Spinal Muscular Atrophy.
    Type: Application
    Filed: August 13, 2009
    Publication date: July 14, 2011
    Inventors: Sergey V. Paushkin, Nikolai A. Naryshkin, Ellen Welch
  • METHODS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20110086833
    Abstract: The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene, compounds and pharmaceutical compositions that increase levels of SMN protein produced from the SMN2 gene, and methods for use thereof in treating of SMA.
    Type: Application
    Filed: May 27, 2009
    Publication date: April 14, 2011
    Inventors: Sergey V. Paushkin, Nikolai Naryshkin, Charles Romfo, Ellen Welch
  • Methods and agents for screening for compounds capable of modulating gene expression
    Publication number: 20050048549
    Abstract: The invention relates to the fields of screening assays, compounds, and methods for altering gene expression and protein levels. In particular, the invention includes assays to screen for agents capable of modulating gene expression in a UTR-dependent manner and agents capable of modulating gene expression.
    Type: Application
    Filed: July 21, 2004
    Publication date: March 3, 2005
    Inventors: Liangxian Cao, Anuradha Mehta, Nikolai Naryshkin, Matthew Pellegrini, Charles Romfo, Panayiota Trifillis, Christopher Trotta