Patents by Inventor Nikolai Petrovsky
Nikolai Petrovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12161710Abstract: An immunogen useful for treating malaria generally includes an immunogenic carrier and an antigenic malaria circumsporozoite protein (CSP) peptide that includes the peptide NPDPNANPNVDPNAN (amino acids 5-19 of SEQ ID NO:1) linked to the immunogenic carrier. The immunogen may be administered to a subject having or at risk of having malaria.Type: GrantFiled: July 24, 2020Date of Patent: December 10, 2024Assignees: UNM RAINFOREST INNOVATIONS, THE JOHNS HOPKINS UNIVERSITY, VAXINE PTY LTD.Inventors: Bryce Chackerian, David S. Peabody, Nikolai Petrovsky, Lucia Jelinkova, Fidel Zavala
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Patent number: 12121574Abstract: An immunogen useful for treating malaria generally includes an immunogenic carrier and an antigenic malaria circumsporozoite protein (CSP) peptide that includes the peptide NANPNVDPNANPNVD (SEQ ID NO:2) linked to the immunogenic carrier. The immunogen may be administered to a subject having or at risk of having malaria. Alternatively, the immunogen may be administered to an individual having or at risk of having Plasmodium falciparum blood stage parasitemia. In some cases, the immunogen can be administered in combination with another therapeutic agent for treating malaria of Plasmodium falciparum blood stage parasitemia.Type: GrantFiled: September 27, 2022Date of Patent: October 22, 2024Assignees: UNM RAINFOREST INNOVATIONS, THE JOHNS HOPKINS UNIVERSITY, VAXINE PTY LTD.Inventors: Bryce C. Chackerian, Fidel P. Zavala, David S. Peabody, Nikolai Petrovsky, Lucie Jelinkova
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Patent number: 11826403Abstract: The present invention relates to the identification of ALMS1 as the missing player involved in the regulation of the insulin-mediated glucose uptake through GLUT4 sorting vesicles, and to the down-regulation of ALMS1 by ?PKC. Accordingly, the present invention relates to a molecule capable of preventing the binding of ?PKC on ALMS1 for use for treating or preventing diabetes, in particular type 2 diabetes. In addition, the present invention relates to a method for identifying molecule capable of preventing the binding of ?PKC on ALMS1.Type: GrantFiled: October 20, 2020Date of Patent: November 28, 2023Assignees: UNIVERSITE DE STRASBOURG, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, VAXINE PTY LTDInventors: Vincent Marion, Nikolai Petrovsky
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Patent number: 11623004Abstract: Disclosed herein are compositions for vaccination against respiratory syncytial virus (RSV) comprising a RSV F polypeptide stabilized in a prefusion conformation and an inulin adjuvant. Also disclosed herein are methods of vaccinating a subject against a respiratory syncytial virus (RSV) infection comprising administering to the subject an RSV F polypeptide stabilized in a prefusion conformation and an inulin adjuvant. In some embodiments, the subject is a female, and the method can reduce RSV infection in the subject and/or in the offspring of the subject. In some embodiments, the method decreases vaccine-enhanced respiratory disease (VERD) and/or eosinophilia in the subject or offspring of the subject.Type: GrantFiled: March 15, 2019Date of Patent: April 11, 2023Assignees: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, CALDER BIOSCIENCES INC., VAXINE PTY LTDInventors: Kerry McGarr Empey, Nikolai Petrovsky, Christopher Marshall
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Publication number: 20230102159Abstract: An immunogen useful for treating malaria generally includes an immunogenic carrier and an antigenic malaria circumsporozoite protein (CSP) peptide that includes the peptide NANPNVDPNANPNVD (SEQ ID NO:2) linked to the immunogenic carrier. The immunogen may be administered to a subject having or at risk of having malaria. Alternatively, the immunogen may be administered to an individual having or at risk of having Plasmodium falciparum blood stage parasitemia. In some cases, the immunogen can be administered in combination with another therapeutic agent for treating malaria of Plasmodium falciparum blood stage parasitemia.Type: ApplicationFiled: September 27, 2022Publication date: March 30, 2023Inventors: Bryce C. Chackerian, Fidel P. Zavala, David S. Peabody, Nikolai Petrovsky, Lucia Jelinkova
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Publication number: 20220280632Abstract: An immunogen useful for treating malaria generally includes an immunogenic carrier and an antigenic malaria circumsporozoite protein (CSP) peptide that includes the peptide NPDPNANPNVDPNAN (amino acids 5-19 of SEQ ID NO:1) linked to the immunogenic carrier. The immunogen may be administered to a subject having or at risk of having malaria.Type: ApplicationFiled: July 24, 2020Publication date: September 8, 2022Inventors: Bryce Chackerian, David S. Peabody, Nikolai Petrovsky, Lucia Jelinkova, Fidel Zavala
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Patent number: 11332503Abstract: The present invention relates to peptides for the treatment or prevention of diabetes mellitus and associated disorders.Type: GrantFiled: June 29, 2018Date of Patent: May 17, 2022Assignees: UNIVERSITE DE STRASBOURG, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), VAXINE PTY LTDInventors: Vincent Marion, Nikolai Petrovsky
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Patent number: 11110167Abstract: The present invention provides a pharmaceutically acceptable composition comprising: particles of inulin; a substance comprising or consisting of one or more pathogen-associated molecular patterns (PAMPs), and an antigen for use inducing or modulating an immune response in a subject, such as modulating an immune response to an antigen or allergen and/or as a vaccine.Type: GrantFiled: May 17, 2017Date of Patent: September 7, 2021Assignee: VAXINE PTY LTDInventor: Nikolai Petrovsky
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Publication number: 20210069301Abstract: The present invention relates to the identification of ALMS1 as the missing player involved in the regulation of the insulin-mediated glucose uptake through GLUT4 sorting vesicles, and to the down-regulation of ALMS1 by ?PKC. Accordingly, the present invention relates to a molecule capable of preventing the binding of ?PKC on ALMS1 for use for treating or preventing diabetes, in particular type 2 diabetes. In addition, the present invention relates to a method for identifying molecule capable of preventing the binding of ?PKC on ALMS1.Type: ApplicationFiled: October 20, 2020Publication date: March 11, 2021Inventors: VINCENT MARION, NIKOLAI PETROVSKY
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Publication number: 20210023195Abstract: Disclosed herein are compositions for vaccination against respiratory syncytial virus (RSV) comprising a RSV F polypeptide stabilized in a prefusion conformation and an inulin adjuvant. Also disclosed herein are methods of vaccinating a subject against a respiratory syncytial virus (RSV) infection comprising administering to the subject an RSV F polypeptide stabilized in a prefusion conformation and an inulin adjuvant. In some embodiments, the subject is a female, and the method can reduce RSV infection in the subject and/or in the offspring of the subject. In some embodiments, the method decreases vaccine-enhanced respiratory disease (VERD) and/or eosinophilia in the subject or offspring of the subject.Type: ApplicationFiled: March 15, 2019Publication date: January 28, 2021Inventors: Kerry McGarr EMPEY, Nikolai PETROVSKY, Christopher MARSHALL
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Publication number: 20200368314Abstract: The present invention relates to peptides for the treatment or prevention of nonalcoholic fatty liver disease (NAFLD), non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), hepatic steatosis (fatty liver), liver fibrosis, liver inflammation, cirrhosis, or hepatocellular carcinoma.Type: ApplicationFiled: August 3, 2018Publication date: November 26, 2020Inventors: VINCENT MARION, NIKOLAI PETROVSKY
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Patent number: 10821159Abstract: The present invention relates to the identification of ALMS1 as the missing player involved in the regulation of the insulin-mediated glucose uptake through GLUT4 sorting vesicles, and to the down-regulation of ALMS1 by ?PKC. Accordingly, the present invention relates to a molecule capable of preventing the binding of ?PKC on ALMS1 for use for treating or preventing diabetes, in particular type 2 diabetes. In addition, the present invention relates to a method for identifying molecule capable of preventing the binding of ?PKC on ALMS1.Type: GrantFiled: January 29, 2015Date of Patent: November 3, 2020Assignees: UNIVERSITE DE STRASBOURG, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, VAXINE PTY LTDInventors: Vincent Marion, Nikolai Petrovsky
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Publication number: 20200216504Abstract: The present invention relates to peptides for the treatment or prevention of diabetes mellitus and associated disorders.Type: ApplicationFiled: June 29, 2018Publication date: July 9, 2020Inventors: VINCENT MARION, NIKOLAI PETROVSKY
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Publication number: 20180169223Abstract: The present invention provides a pharmaceutically acceptable composition comprising: particles of inulin; a substance comprising or consisting of one or more pathogen-associated molecular patterns (PAMPs), and an antigen for use inducing or modulating an immune response in a subject, such as modulating an immune response to an antigen or allergen and/or as a vaccine.Type: ApplicationFiled: May 17, 2017Publication date: June 21, 2018Applicant: Vaxine Pty LtdInventor: Nikolai Petrovsky
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Publication number: 20170368167Abstract: The present technology relates to compositions comprising inulin particles for use in the enhancement of immune responses to neuronal self-antigens for treating or preventing neurodegenerative diseases, in a subject. Also provided are pharmaceutically acceptable compositions comprising: particles of inulin; a substance comprising one or more pathogen-associated molecular patterns (PAMPs); and a neuronal self-antigen fused to carrier, and methods and uses of the composition for inducing or modulating an immune response in a subject, such as modulating an immune response to a neuronal self-antigen as a vaccine. Also provided are vaccine compositions comprising inulin particles, and an antigen-binding carrier material, and methods and uses of the vaccine.Type: ApplicationFiled: June 6, 2016Publication date: December 28, 2017Inventors: Michael Agadjanyan, Anahit Ghochikyan, Nikolai Petrovsky
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Publication number: 20170239349Abstract: The present technology relates to compositions comprising inulin particles for use in the enhancement of immune responses to neuronal self-antigens for treating or preventing neurodegenerative diseases, in a subject. Also provided are pharmaceutically acceptable compositions comprising: particles of inulin; a substance comprising one or more pathogen-associated molecular patterns (PAMPs); and a neuronal self-antigen fused to carrier, and methods and uses of the composition for inducing or modulating an immune response in a subject, such as modulating an immune response to a neuronal self-antigen as a vaccine. Also provided are vaccine compositions comprising inulin particles, and an antigen-binding carrier material, and methods and uses of the vaccine.Type: ApplicationFiled: June 6, 2016Publication date: August 24, 2017Inventors: Michael Agadjanyan, Anahit Ghochikyan, Nikolai Petrovsky
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Publication number: 20170000857Abstract: The present invention relates to the identification of ALMS1 as the missing player involved in the regulation of the insulin-mediated glucose uptake through GLUT4 sorting vesicles, and to the down-regulation of ALMS1 by ?PKC. Accordingly, the present invention relates to a molecule capable of preventing the binding of ?PKC on ALMS1 for use for treating or preventing diabetes, in particular type 2 diabetes. In addition, the present invention relates to a method for identifying molecule capable of preventing the binding of ?PKC on ALMS1.Type: ApplicationFiled: January 29, 2015Publication date: January 5, 2017Inventors: VINCENT MARION, NIKOLAI PETROVSKY
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Patent number: 9492547Abstract: The present invention relates to a new polymorphic form of inulin, designated delta inulin (dIN), to methods for the preparation of dIN, compositions comprising dIN and uses thereof. The present invention also relates to the use of dIN and compositions comprising dIN in the preparation of gamma inulin (gIN), compositions comprising gIN and uses thereof.Type: GrantFiled: September 1, 2005Date of Patent: November 15, 2016Assignee: VAXINE PTY LTDInventors: Peter D. Cooper, Nikolai Petrovsky
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Publication number: 20140314739Abstract: The present invention provides a composition comprising or consisting of inulin particles for use in the reduction or inhibition of inflammation, and/or for treating or preventing inflammatory disease, in a subject. Also provided is a pharmaceutically acceptable composition comprising: particles of inulin; and a substance comprising or consisting of one or more pathogen-associated molecular patterns (PAMPs), or an equivalent kit of parts, and methods and uses of the composition and kit for inducing or modulating an immune response in a subject, such as modulating an immune response to an antigen or allergen and/or as a vaccine. Also provided is a single-dose vaccine composition comprising inulin particles, an antigen and, optionally, an antigen-binding carrier material, and methods and uses of the vaccine.Type: ApplicationFiled: June 19, 2012Publication date: October 23, 2014Applicant: Vaxine Pty Ltd.Inventor: Nikolai Petrovsky
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Publication number: 20090029940Abstract: The present invention relates to a new polymorphic form of inulin, designated delta inulin (dIN), to methods for the preparation of dIN, compositions comprising dIN and uses thereof. The present invention also relates to the use of dIN and compositions comprising dIN in the preparation of gamma inulin (gIN), compositions comprising gIN and uses thereof.Type: ApplicationFiled: September 1, 2005Publication date: January 29, 2009Inventors: Peter D. Cooper, Nikolai Petrovsky