Patents by Inventor Nikolai Schnittke

Nikolai Schnittke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting p63 to re-activate dormant reserve stem cells in olfactory epithelium
    Patent number: 9080172
    Abstract: Disclosed herein is a method for activating a dormant epithelial stem cell, or population thereof, to a state of multipotency comprising, reducing the level of ?Np63 in the cell(s). The dormant epithelial stem cell(s) may be a horizontal basal cell (HBC) of the olfactory epithelium and the level of ?Np63 may be reduced by contacting the cell or population with an effective amount of one or more agents that downmodulate ?Np63. One example of an agent is an RNAi. Also disclosed is a method for treating olfactory dysfunction in a subject, comprising activating HBCs of the subject by reducing the level of ?Np63 in one or more HBCs of the subject, to thereby treat the olfactory dysfunction. Activated horizontal basal cell (HBCs) are also disclosed.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: July 14, 2015
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: James E. Schwob, Nikolai Schnittke, Adam I. Packard
  • TARGETING p63 TO RE-ACTIVATE DORMANT RESERVE STEM CELLS IN OLFACTORY EPITHELIUM
    Publication number: 20140221456
    Abstract: Disclosed herein is a method for activating a dormant epithelial stem cell, or population thereof, to a state of multipotency comprising, reducing the level of ?Np63 in the cell(s). The dormant epithelial stem cell(s) may be a horizontal basal cell (HBC) of the olfactory epithelium and the level of ?Np63 may be reduced by contacting the cell or population with an effective amount of one or more agents that downmodulate ?Np63. One example of an agent is an RNAi. Also disclosed is a method for treating olfactory dysfunction in a subject, comprising activating HBCs of the subject by reducing the level of ?Np63 in one or more HBCs of the subject, to thereby treat the olfactory dysfunction. Activated horizontal basal cell (HBCs) are also disclosed.
    Type: Application
    Filed: May 25, 2012
    Publication date: August 7, 2014
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: James E. Schwob, Nikolai Schnittke, Adam I. Packard